It took...
📆15 months
⚡️lots of computational time (and electricity😓)
🧐2.5 rounds of review
💾92 code commits
📝260 manuscript commits
🪧3 new DOIs
🧔153 new white hairs on my beard
but MorF is now accepted at Genome Biology!
genomebiology.biomedcentral.…
what's new? ⏬ 1/
You might ask: why not submit to a journal? We have too many talented scientists, and too precious little funding, to tolerate the current academic standard of publish-or-perish. We should build an impact-centric nonprofit research culture where we instead publish-and-persist.
We are very excited to announce the Platynereis Satellite Meeting at the EuroEvoDevo in Finland. Abstracts can be submitted via the meeting registration. We will prioritize Platynereis abstracts but other annelid friends are welcome to submit and attend. @EED2024#WormWednesday
Thanks to funding by @FWF_at we will put worm snails in the limelight of evodevo and omics research! 2 fully funded PhD positions being announced soon. Feel free to spread the word and send inquiries directly to me if interested. 🐌🪱
every once in a while I try to create another conda environment that has python/R interoperability and I am reminded again that we don't live in the nice timeline
today I learned that if
1) a gene is expressed a little bit all over the place
2) I am writing a paper/want to sound pompous
the correct phrasing is "it is expressed in a punctate pattern" #sciencespeak
I need to preface this by saying the data seems sound and this had no real implications on the science described in the paper, but I still had to chuckle at this figure (anonymised slightly)
Are you interested in...
- winding scientific journeys🤷♀️
- revisiting conventional wisdom🧙♂️
- cutting-edge experiments🪚
- combining multiple data modalities🧬🔬⚡️🎥
- a result that can be summarised in one sentence?
...well then, @FabianRuperti has just the thing for you!
biorxiv.org/content/10.1101/…
Did you know that sponges can move? @FabianRuperti with @savitski_lab and @Prevedel_lab studied sponge movement and found an evolutionary ancient mechanism controlling cellular tension and defense which is also present in our vasculature! A thread 🧵:
this, again🥲Digging through notebooks to piece together the cluster assignments or figure out which cells made it through filtering is not my idea of "reproducible". For the love of God, please upload your final .h5ad/.RDS somewhere🙏
It is the year of our Lord 2023 and people still can't find it in them to actually share .RDS/.h5ad objects? Applause for uploading the raw .mtx on GEO, but ✨I don't want to re-do literally all the steps of your analysis✨, I just wanna look at something real quick #singlecell
this is the equivalent of assembling a genome and then only uploading the raw fastq with instructions on how to assemble🤷♀️ Like, sure, that is *technically* reproducible, yay us
It is the year of our Lord 2023 and people still can't find it in them to actually share .RDS/.h5ad objects? Applause for uploading the raw .mtx on GEO, but ✨I don't want to re-do literally all the steps of your analysis✨, I just wanna look at something real quick #singlecell
new suggestions for author order on papers:
- alphabetical, but only using middle names🔡
- alphabetical, but only using the Linnaean name of fav species🪱
- via table tennis tournament🏓
- ascending height📈
- by # of private GitHub repos of unfinished projects (ascending)🥲
More evidence of the normal physiological roles of cell senescence.
In an invertebrate cnidarian, senescent cells can reprogram neighbouring somatic cells into stem cells and drive whole-body regeneration.
Great work by @thecocodium et al @CellReports!
cell.com/cell-reports/fullte…
Why is there so much disorder in eukaryotic proteins? What is its relationship with condensates? Why can some proteins be saved but others get degraded? After years in the making, we think we have answers and they're all connected. Excited to share a 🧵:
biorxiv.org/content/10.1101/…
seems to be a law of the universe that any and all exams are *supposed* to produce funny blooper answers by the students. Super proud of them nonetheless, they've crushed it!
In what has proven to be a great month for the technical side of single cell RNA-seq, here's another excellent paper that reviews multiplexing. Congrats and thank you!
Happy to present our new preprint! We ran a head-to-head comparison of sample multiplexing reagents for single-cell RNA-Seq on the same samples on the same day. 1/9 biorxiv.org/content/10.1101/…