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Guy Rutter1 @guy_rutter

Professor of Medicine Université de Montréal, Imperial College London, Nanyang Technological University Singapore. Wellcome Investigator.

Joined November 2014
  • Tweets 1,317
  • Following 636
  • Followers 1,446
76 Photos and videos
Our appreciation in Diabetologia of Steve Ashcroft who sadly passed away in November. Steve made fundamental contributions to our understanding of beta cell glucose sensing including the substrate site hypothesis and the role of KATP channels.
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NSERC / CRSNG
@NSERC_CRSNG
9 Dec 2025
📢 #CIHR, #NSERC and #SSHRC are proud to launch the new Canada Impact Research Training Awards to support the recruitment of international doctoral students and postdoctoral researchers to Canada. Learn more about this new initiative: ▶️ tinyurl.com/yc54p4da
IMAGE: Background in shades of pink to orange with undulating horizontal white lines in the center. Canada logo in white at the bottom right.

ALT IMAGE: Background in shades of pink to orange with undulating horizontal white lines in the center. Canada logo in white at the bottom right.

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TIPS_SPIIE
@TIPS_SPIIE
9 Dec 2025
📢Today, the #GC launched new programs to attract international researchers to Canada. ✅ Canada Impact Research Chairs ✅ Canada Impact Emerging Leaders Get all the details here: canada.ca/en/impact-plus-cha… @SSHRC_CRSH @NSERC_CRSNG @CIHR_IRSC @InnovationCA @ISED_CA
Launch of the Canada Global Impact Research Talent Initiative

ALT Launch of the Canada Global Impact Research Talent Initiative
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Leveraging the inhibition of disallowed beta cell genes as a therapeutic strategy!
Daniel J Drucker@DanielJDrucker
12 Dec 2025
LDHA inhibition could be a novel therapeutic strategy for #diabetes treatment link.springer.com/article/10… @DiabetologiaJnl
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Mark Carney
@MarkJCarney
11 Dec 2025
Canada’s new government is investing big to attract world-class talent in science and technology — and become an innovation powerhouse.
Screenshot from an article of the Financial Post. The headline reads: Canada launches billion dollar plan to recruit top researchers.

ALT Screenshot from an article of the Financial Post. The headline reads: Canada launches billion dollar plan to recruit top researchers.

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Eric Topol
@EricTopol
11 Dec 2025
29%—That's a lot of weight loss, folks Triple GLP-1 drug receptor retatrutide Compares with avg weight loss with Zepbound 21%, Wegovy (Ozempic) 15% nytimes.com/2025/12/11/healt…

Major Weight Loss and Knee-Pain Relief Seen With New Eli Lilly Drug

The maker of Zepbound reported results from a study of retatrutide, which targets three hormones in the body and led to much more weight loss than any approved drug.

nytimes.com
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ER calcium stores contribute to glucose-induced Ca2 waves and interce... sciencedirect.com/science/ar… Revisiting an old question with new tools! @L_F_D_S #BillLouch @CRCHUM @CRCHUM_CELLS @wellcometrust @CIHR_IRSC @BT1D_CA
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Gilles Gouspillou@GGouspillou
13 Nov 2025
Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia | Nature Metabolism nature.com/articles/s42255-0…

Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during...

Nature Metabolism - Tumour-induced dysregulation of cAMP–PKA–CREB1 signalling in skeletal muscle is shown to be a driver of mitochondrial dysfunction, contributing to cancer cachexia in...

nature.com
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Out today in Diabetes! Additive Effects of Dorzagliatin and Glucagon-Like Peptide-1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice | Diabetes | American Diabetes Association ⁦@CRCHUM⁩ ⁦@ImperialMDR⁩ diabetesjournals.org/diabete…

Additive Effects of Dorzagliatin and Glucagon-Like Peptide 1 Receptor Agonism in a Novel Mouse...

Glucokinase (GK) catalyzes the key regulatory step in glucose-stimulated insulin secretion (GSIS). Correspondingly, hetero- and homozygous mutations in hum

diabetesjournals.org
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Nature Metabolism
@NatMetabolism
8 Oct 2025
#Throwback REVIEW | @guy_rutter , @BennyScience et al Exploring pancreatic beta-cell subgroups and their connectivity nature.com/articles/s42255-0…

Exploring pancreatic beta-cell subgroups and their connectivity

Nature Metabolism - Rutter and Benninger discuss the role of putative controlling beta-cell populations in the context of intra-islet connectivity, how such a cellular hierarchy might be achieved...

nature.com
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Relaunching our @CRCHUM Cardiometabolic Axis data sessions data sessions today with amazing talks from #mathiasguayasamin and #luisdelgadillosilva. #ciaranmurphyroyal @CRCHUM_CELLS
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Dr. Alice Cheng@AliceYYCheng
5 Oct 2025
Not one, but TWO endocrinologists to join the Canadian Medical Hall of Fame in 2026. Both Drs Hegele and Zinman have changed the way we treat metabolic disorders forever. In addition though … they are just kind humans. Congratulations!!🎉🎊🎈
Canadian Medical Hall Fame@CdnMedHallFame
2 Oct 2025
Join us in congratulating the #2026CMHFInductees!cdnmedhall.ca/induction PAVEL HAMET, MD PhD ROBERT ALEXANDER HEGELE, MD MICHAEL D. HILL, MD MARY R. L'ABBÉ, PhD MORAG PARK, PhD BERNARD ZINMAN, MDCM @kellygrant1 @Megan_Ogilvie @LaurenPelley @DubinskiKa4985 @JenLeeCBC @Avis_Favaro
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Important new review from my @CRCHUM colleague #MarcDonath
Daniel J Drucker@DanielJDrucker
3 Oct 2025
Inflammation is a key driver of the pathophysiology of cardiometabolic disorders #obesity #T2D and new metabolic medicines based on GLP-1 action exert their magic in part by reducing inflammation. A new review from Professor Donath summarizes the field sciencedirect.com/science/ar…
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LKCMedicine Research
@lkcmedresearch
29 Sep 2025
I‑BET151 modulates glucokinase gene expression and beta cellfunction in part through changes in FOXO1 expression rdcu.be/eIBCo Assoc. Prof Yusuf Ali's team @NTU_LKCMedicine in collaboration with @guy_rutter and @astar_research discovered that BET protein inhibition (I-BET151) impacts pancreatic β-cell function. 🔹 ↑ Glucose excursions 🔹 ↓ Insulin response 🔹 Downregulation of MODY genes (Hnf4α, Gck, Hnf1α, Glut2) & PI3K–Akt pathway ⚠️ BET therapies may impair β-cell health — caution warranted. #Diabetes #Epigenetics #BETinhibition
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All true. But the same rigour should be applied to ALL the antibodies we use. Those against glucokinase are a case in point.
David Hodson@daveyboyhod
3 Sep 2025
In some of these papers, glp1r detection is a small element. In others it's a large element. Don't trust antibody vendors, and do the legwork. As a field we are always happy to provide reagents/models to help with validation.
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Our new report with #YaChiHuang ⁦#MarjanRupnik using high-speed imaging in pancreatic slices. Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells | bioRxiv biorxiv.org/content/10.1101/…

Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring...

Glucose and paracrine regulation on α-cells, particularly with respect to sex differences, remains unclear. Hence, we imaged islets of GluCre:GCaMP6ffl/fl mice in pancreatic slices, additionally...

biorxiv.org
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Nature Metabolism
@NatMetabolism
23 Aug 2025
#Throwback REVIEW | @guy_rutter , @BennyScience et al Exploring #pancreatic #BetaCell subgroups and their connectivity nature.com/articles/s42255-0…

Exploring pancreatic beta-cell subgroups and their connectivity

Nature Metabolism - Rutter and Benninger discuss the role of putative controlling beta-cell populations in the context of intra-islet connectivity, how such a cellular hierarchy might be achieved...

nature.com
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Our new kid on the block to rival or beat existing dual agonists? Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel GLP-1R/GIPR dual agonist, HISHS-2001 - PubMed. pubmed.ncbi.nlm.nih.gov/4083…

Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in...

HISHS-2001 represents a novel dual receptor agonist with a promising pharmacological profile and actions. Future clinical studies will be needed to assess the safety and efficacy of this molecule in...

pubmed.ncbi.nlm.nih.gov
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The influence of metformin treatment on the circulating proteome - PubMed. Important new study led by ⁦@LeentHart⁩ and the EU-funded IMI -Rhapsody and IMI-DIRECT consortia pubmed.ncbi.nlm.nih.gov/4068…

The influence of metformin treatment on the circulating proteome - PubMed

Innovative Medicines Initiative Joint Undertaking 2, under grant agreement no. 115881 (RHAPSODY) and the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115317 (DIRECT),...

pubmed.ncbi.nlm.nih.gov
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Thanks again @SoleimanpourLab for the opportunity to be involved and to #MarieGasser for her vital input! Also grateful to the ever-resourceful @carapetop for her help!
Scott Soleimanpour@SoleimanpourLab
21 Jul 2025
Replying to @nesvilab @epgnomike @guy_rutter @NIDDKgov @ADA_DiabetesPro @BreakthroughT1D @DeptVetAffairs
P.S. we would be remiss if we did not also thank the amazing reviewers and editor who made our work better and more complete. As well as @cevansmo for the lovely commentary on our work! nature.com/articles/s42255-0…
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