FlatProt: 2D visualization eases protein structure comparison 1. FlatProt is a new tool that standardizes 2D visualizations of 3D protein structures, enabling consistent, scalable, and intuitive comparison of protein families across entire proteomes. 2. The tool solves a fundamental bottleneck in structural biology: viewing and comparing many 3D protein structures on 2D screens without losing key information—an essential task in drug design and protein function analysis. 3. FlatProt employs both inertia-based and family-based structure rotation to project proteins consistently into 2D space, preserving structural orientation across related proteins and improving comparability. 4. It supports domain-aware visualizations, simplified segment representations (e.g., helices as zigzags, strands as triangles), and overlay of annotations like disulfide bonds or divergent regions via lDDT scores. 5. The tool enables consistent visualization for structurally diverse families, like Three-Finger Toxins (3FTx) and Kallikreins (KLK), making it easier to detect conserved features and family-specific variations. 6. Unlike prior tools (e.g., Pro-origami, SSDraw, iCn3D), FlatProt combines interactivity, scalability, and structural accuracy, while allowing customization and integration with SCOP/CATH classifications. 7. Benchmarking on 1,000 proteins from the human proteome shows FlatProt scales well across proteins of varying sizes (16–2,663 residues), with <6s runtime per structure on standard hardware. 8. FlatProt supports large-scale family overlay plots—e.g., for KLK proteins—enabling simultaneous visualization of 40 members in a single graphic with opacity reflecting structural conservation. 9. Designed for accessibility, FlatProt requires only Python and common bioinformatics tools (DSSP, Foldseek), and can run on typical laptops, democratizing large-scale structural comparisons. 10. By providing consistent, lightweight, and interpretable 2D protein maps, FlatProt paves the way for broader adoption of structural analysis in bioinformatics pipelines, education, and AI model training. 💻Code: github.com/t03i/FlatProt 📜Paper: biorxiv.org/content/10.1101/… #ProteinStructure #BioinformaticsTools #2DVisualization #StructuralBiology #SCOP #CATH #Foldseek #SecondaryStructure #ComputationalBiology #AI4Science

FlatProt: 2D visualization eases protein structure comparison 1. FlatProt is a new tool that standardizes 2D visualizations of 3D protein structures, enabling consistent, scalable, and intuitive comparison of protein families across entire proteomes. 2. The tool solves a fundamental bottleneck in structural biology: viewing and comparing many 3D protein structures on 2D screens without losing key information—an essential task in drug design and protein function analysis. 3. FlatProt employs both inertia-based and family-based structure rotation to project proteins consistently into 2D space, preserving structural orientation across related proteins and improving comparability. 4. It supports domain-aware visualizations, simplified segment representations (e.g., helices as zigzags, strands as triangles), and overlay of annotations like disulfide bonds or divergent regions via lDDT scores. 5. The tool enables consistent visualization for structurally diverse families, like Three-Finger Toxins (3FTx) and Kallikreins (KLK), making it easier to detect conserved features and family-specific variations. 6. Unlike prior tools (e.g., Pro-origami, SSDraw, iCn3D), FlatProt combines interactivity, scalability, and structural accuracy, while allowing customization and integration with SCOP/CATH classifications. 7. Benchmarking on 1,000 proteins from the human proteome shows FlatProt scales well across proteins of varying sizes (16–2,663 residues), with <6s runtime per structure on standard hardware. 8. FlatProt supports large-scale family overlay plots—e.g., for KLK proteins—enabling simultaneous visualization of 40 members in a single graphic with opacity reflecting structural conservation. 9. Designed for accessibility, FlatProt requires only Python and common bioinformatics tools (DSSP, Foldseek), and can run on typical laptops, democratizing large-scale structural comparisons. 10. By providing consistent, lightweight, and interpretable 2D protein maps, FlatProt paves the way for broader adoption of structural analysis in bioinformatics pipelines, education, and AI model training. 💻Code: github.com/t03i/FlatProt 📜Paper: biorxiv.org/content/10.1101/… #ProteinStructure #BioinformaticsTools #2DVisualization #StructuralBiology #SCOP #CATH #Foldseek #SecondaryStructure #ComputationalBiology #AI4Science

本日17時から行います。 ぜひご覧ください！ ✳︎ 昨年アップした動画ではから改変された2DVisualizationのブロックの入手方法や、自分のモデルでの利用の仕方なども追加で説明しています。

Y tú ¿En dónde has encontrado la inspiración? tricksterstudio.com #Shi-Ra #collection #girlpower #womanillustration #superheroes #supergirl #conceptart #conceptartwork #2dcharacter #2dvisualization #digitalart #2didea #digitalart #trickandfun

We are providing Professional Certification in 2D Visual Art & Animation. For more information visit: pixelartga.com/index.php/2d-… #GameDev #Indie #IndieDev #GamesAcademyPakistan #TeamGameDev #CollaborativeLearning #LearnGameDev #2DVisualization #Animation #OnlineLearning

Here's another design of modern bedroom designed by @rubepax #interiordesign #interiorstyling #officedecor #fitout #Maintenance #autocad @3dvisualization #2dvisualization

We don't mean to brag, but... #CADdata #CAD #Catia #Visualization #3DVisualization #2DVisualization #3DCADViewer #2DViewer #CADProblems

#Visualization catering to users in sales, marketing, service, change management, documentation & more. Free trial: 3dviewstation.com #CADdata #CAD #Catia #Visualization #3DVisualization #2DVisualization #3DCADViewer #2DViewer #CADProblems #WebViewer #Creo #ProE #NX

Thank you @tenlinksnews for sharing the exciting news about 3DViewStation v2017.1! Check it out: bit.ly/2B4hcv4 #CADdata #CAD #Catia #Visualization #3DVisualization #2DVisualization #3DCADViewer #2DViewer #CADProblems #WebViewer #Creo #ProE #NX #SolidWorks #IPP

Read about 3DViewStation in today's @IBTimes! Click: bit.ly/2hHBH9g #CADdata #CAD #Catia #Visualization #3DVisualization #2DVisualization #3DCADViewer #2DViewer #CADProblems #WebViewer #Creo #ProE #NX #SolidWorks

3DViewStation Version 2017.1 has just been released! Be the first to get your hands on it. Free 30 day trial: bit.ly/2zJcqGg #CADdata #CAD #Catia #Visualization #3DVisualization #2DVisualization #3DCADViewer #2DViewer #CADProblems #WebViewer #Creo #ProE #NX #SolidWorks