LabAnimal retweeted
📢 New paper is out!
This review focuses on the current landscape of #TB biomarker discovery in different #AnimalModels. The article was proudly produced under the umbrella of the @ADVANCE_TB action.
Link to the full text: nature.com/articles/s41684-0…
@GTRecerca #OpenAccess
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❓Tech Q&A | Can #Emapticap pegol be given intrathecally in rats?
• No reported studies on intrathecal use → safety/feasibility unclear
• As a #PEGylated aptamer, # CNS delivery may differ from small molecules
• If attempted: can be dissolved in DMSO, inject ~1–2 μL (monitor neurotoxicity)
• Include dose-ranging groups to determine optimal concentration
#DrugDelivery #AnimalModel
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Early motor deficits, sleep dysfunction, and selective dopaminergic neuron loss in a PARK7 (DJ-1) knockout model reported in Scientific Reports. DJ-1 mutations cause early-onset PD, and this model recapitulates key prodromal features — sleep disruption preceding motor symptoms. Understanding the temporal sequence of pathology is crucial for identifying therapeutic windows.
doi.org/10.1038/s41598-026-3…
#ParkinsonsDisease #DJ1 #AnimalModel #ProdromalPD #DopamineNeurons
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Sequential Changes in Range of Motion and Capsular Fibrosis Following Remobilization in a Rat Adhesive Capsulitis Model Using Cast Immobilization
🌷doi.org/10.4055/cios25059
Clin Orthop Surg. 2026;18(1). Du-Han Kim
#AdhesiveCapsulitis #FrozenShoulder #AnimalModel #Rat
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#Animalmodel-based adjunctive #herbaltherapy in #autismspectrum disorder: Therapeutic advances and prospects
doi.org/10.5455/jabet.2025.2…
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Our new detailed #review to guide #animalmodel selection in #sarcoma #research is now online!
@AMCzarnecka @NIO_PIB #mousemodels #preclinicalmodels #xenograft #pdx #cdx
@NCN_PL
doi.org/10.1007/s00018-025-0…
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22 Dec 2025
Vědci z @MBU_AVCR ukazují, že střevní #mikrobiota může ovlivnit účinnost léčby roztroušené sklerózy. Kombinace klinických dat a zvířecího modelu pomohla lépe pochopit souvislosti mezi střevem a imunitou.
#PokusyNaZvířatech #EARA #AnimalResearch #AnimalModel #RoztroušenáSkleróza
17 Dec 2025
🧠 Can the gut affect how well multiple sclerosis treatment works? New Czech research says yes.
📄 Ocrelizumab transiently alters microbiota and modulates immune response depending on treatment outcome; Coufal, S. et al. iScience (2025)
sciencedirect.com/science/ar…
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18 Nov 2025
Honoured to receive my 8th consecutive award at the Argentine Neurology Congress for my work in Multiple Sclerosis. Grateful to the jury for the recognition.#research #MultipleSclerosis #animalmodel
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5 Nov 2025
📢 #NewlyPublished!
🧠 What happens when the brain loses its #tryptophan balancer?
Knocking out KAT II triggers oxidative chaos - behavior stays calm, but chemistry goes wild!
👨🔬@emtanaka
🔗 brnw.ch/21wXe5q
#Kynurenine #BrainMetabolism #AnimalModel
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21 Sep 2025
#Article in @MedComm_MC
A Novel Genetic TDP‐43 Pig Model Mimics Multiple Key ALS‐Like Features 👉doi.org/10.1002/mco2.70330
#AmyotrophicLateralSclerosis #APOE4 #MovementDisorder #PigModel #SOD1 #TDP43 #AnimalModel
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3 Sep 2025
Nice installation of RWD anesthesia ventilation system.
Compact size, Easy set up, Muti-function, User Friendly and more...
#preclinicalresearch #animalmodel #rodentmodel #neuroscience #neurophysiology #electrophysiology #immunology
RWD Life Science rwdstco.com
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♻️ Please share, friends and colleagues!
📢 Hiring postdocs for my lab @UCBerkeley. Let’s make discoveries as iconic as the Campanile!
👉 Apply: bit.ly/ShiyuXiaLab
Seeking:
🧪 Biochemists
🧬 Structural Biologists
🛠️ Synthetic Biologists
🐭 Animal Model Experts
#Biochemistry #StructuralBiology #SyntheticBiology #AnimalModel #PostdocJobs
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23 Jul 2025
23 Jul 2025
🐁🧪Overcoming P-glycoprotein-mediated multidrug resistance in cancer cells through micelle-forming PHPMA-b-PPO diblock copolymers for doxorubicin delivery
M. Kaňa, A. Braunová, D. Starenko, M. Frejková, J. Bouček, B. Říhová, M. Kovář, T. Etrych, M. Šírová; JCR (2025)
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14 Jul 2025
3 Jul 2025
🧬In a collaborative study led by @CZphenogenomics and @imgprague , we discovered that the scaffolding protein CUL4A can suppress cancer development in the colon by regulating intracellular signaling. This finding challenges the commonly held view of CUL4A as a cancer-promoting factor in other tissues.
🔎Our team @BarinkaLab at #IBT contributed recombinant enzymes and biochemical expertise that helped clarify this regulatory pathway. These insights deepen our understanding of how protein networks maintain intestinal health - and how their disruption may lead to cancer.
@BIOCEV_science @CzechAcademy
📖 Read the full study in Cancer Letters 👉 doi.org/10.1016/j.canlet.202…
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30 Jun 2025
New Findings on #PulsatileECMO: Verification of the Potential to Improve #Antithrombogenicity of a Membrane Oxygenator Using Pump-Generated Pulsatile Flow in an Innovative #AnimalModel
👉tinyurl.com/m8prcf8y
@Sciencetokyo_en🇯🇵| #DualExtracorporealCirculation
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12 Jun 2025
🎯Effect of ibuprofen on amelogenesis in Wistar rats
🔗doi.org/10.1590/1678-7757-20…
#molarhypomineralization #animalmodel #ibuprofen #amelogenes
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🦁 Majestic. Powerful. Fully Rigged.
Introducing our ultra-realistic lion 3D model, complete with fur and animation-ready rig.
Perfect for animation tests, creature design, or VFX production.
🔗 vfxgrace.com/product/lion-ri…
#3DAnimation #3dmodeling #CGAnimal #CGArtist #AnimalModel
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21 May 2025
🚨Check out our new publication:
Synergistic inhibition of CitH3 and S100A8/A9: A novel therapeutic strategy for mitigating sepsis induced inflammation and lung injury
➡️Link: pubmed.ncbi.nlm.nih.gov/4039…
#MolecularTarget #Sepsis #AnimalModel
@UMich @MGHPathology @MGBpathology
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16 May 2025
🌟Calling for Papers🌟
📖Advances in Laboratory Animal Research for Precision Medicine in #Cardiovascular #Diseases
🧑🔬Guest Editor: Dr. Conrado Calvo
⏰Submission Deadline: 30 September 2025
🔗Find out more: mdpi.com/journal/ijms/specia…
#experiments #heartfailure #animalmodel
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