Join us as a #postdoc in #immunology studying dendritic cells and #cellidentity using #CRISPR and #singlecell genomics at UCSD. Postdoctoral Scholar – Dendritic Cell Biology & Reprogramming, UCSD @Idoyaga_Lab University of California San Diego See the full job description on jobRxiv: jobrxiv.org/job/university-o… #cellidentity #cellreprogramming #CRISPRediting #dendriticcells #epigenomics #immunecellfunction #plasticity #snmultiomics #ScienceJobs jobrxiv.org/job/university-o…

1/4 We are recruiting! Our lab was awarded a PhD grant from @scilifelab Data-driven Life Science (DDLS) Research School for the project “A virtual cellular reprogramming screening platform”. #DataDrivenLifeScience #CellReprogramming

💥 New Special Issue open for submission! 🔗 tinyurl.com/3dd5tktf 🕑 The deadline for manuscript submissions is 31 August 2026 📌 #cardiactissueengineering #myocardialregeneration #biomaterials #3Dbioprinting #stemcells #organonaChip #drugdelivery #cellreprogramming

Why is rejuvenation impossible without renewing the sources of conception? To achieve human rejuvenation, it is necessary to consider all stages, beginning with conception, embryonic development, birth, growth, development, aging, and old age. Let's not even touch on death for now. When a child is conceived, both parents—the father and mother, their sperm, and the egg—are necessarily involved. The fertilized central cell—the zygote—already contains the beginning of life's time, the space of life, and respiration. All channels, connections, meridians, and life sources from the parents are connected for life through this primary central cell with the entire person as a whole. The beginning of life's time, the space of life, respiration, and subsequent life are directly connected to our prototype hourglass, in which life's time inexorably, grain by grain, awakens into the space of death, which absorbs our life. One doesn't need to understand the intricacies of life's structures to understand that in order to live longer, the sand in the hourglass must never run out. You can't extend life by improving the quality of sand, not its volume. But volume is limited. It's a vital resource that nature provides to every living creature, plant, and human. The only option is for your primary sources to undergo renewal and receive a new, unlimited life resource. But time cannot be turned back. You must, while you're still alive—I emphasize, while you're still alive—move on to the next stage of your life and renew yourself and your parental sources in a new dimension, plane, parallel world—whatever you want to call this state. There will never be a positive result from applying any kind of rejuvenation midway through maturation and cell development. Only renewal of the sources of conception can and will result in natural cell renewal. This begins with the renewal of the parental sources (sperm and egg) and their participation in the formation of the first renewed central cell, from which renewal will proceed through cell division, the growth and development of the embryo, and the birth and growth of a renewed person at a new stage of development. The free rejuvenation shop closes on February 28th. From now on, only informed and paid choices are available. #Rejuvenation #Longevity #CellReprogramming #Immortality Почему омоложение невозможно без обновления источников зачатия. Чтобы осуществить омоложение человека, необходимо рассмотреть все этапы, начиная от зачатия, развития эмбриона, рождения, роста, развития, старения и старости. Смерть пока трогать не будем.При зачатии ребенка в обязательном порядке принимают участие оба родителя — отец и мать, их сперматозоид, и яйцеклетка. В оплодотворённой центральной клетке — зиготе — уже заложено начало времени жизни, пространства жизни, дыхания. Все каналы, связи, меридианы, источники жизни от родителей на всю жизнь связаны через эту первичную центральную клетку со всем человеком в целом. Начало времени жизни, пространства жизни, дыхания и дальнейшая жизнь напрямую уже связаны с нашим прототипом песочных часов, в которых время жизни неумолимо, песчинка за песчинкой, просыпается в пространство смерти, которое и поглощает нашу жизнь. Не нужно особо разбираться в тонкостях структурах жизни, чтобы понять: для того чтобы прожить дольше, нужно, чтобы песок в песочных часах не заканчивался. Не получится продлить жизнь, улучшая качество песка, а не его объём. Но объём ограничен. Это жизненный ресурс, который природа выдаёт каждому живому существу, растению, а также человеку. Единственный вариант — это когда твои первичные источники пройдут обновление и получат новый неограниченный ресурс жизни. Но время не воротишь назад. Нужно при жизни — подчёркиваю, при жизни — перейти на следующий виток жизненного пути и обновить себя и свои родительские источники в новом измерении, плане, параллельном мире — как угодно назовите это состояние. Никогда не будет положительного результата, если применять какое-то омоложение в середине созревания, развития клеток. Только обновление источников зачатия может и будет результатом, при котором естественным путём пойдёт обновление клеток. Начиная с обновления родительских источников (сперматозоида и яйцеклетки) и их участия в формировании первой обновлённой центральной клетки, от которой и пойдёт обновление в делениях клеток, роста и развития эмбриона, рождения и роста обновлённого человека нового витка развития. Лавочка бесплатного омоложения закрывается 28 февраля. Дальше — только осознанный и платный выбор. #Омоложение #Долголетие #ПерепрограммированияКлеток #Бессмертие

나는 이 사실을 X에서 알았다. 그게 가장 마음이 아프다. 과학은 이미 여기까지 와 있는데, 우리는 왜 이렇게 늦게 알게 되는 걸까. 사람들이 암에서 해방되는 날이 하루라도 빨리 오기를 진심으로 바란다. 🙏🕊️ I learned about this on X. And honestly, that hurts the most. Science has already come this far, yet we still learn about it too late. I sincerely hope for the day when people are finally free from cancer. 🙏🕊️🧬 국제 학술지 게재 논문: [📊 Reversion Pathway Diagram] Cancer research is exploring how malignant cells can be reprogrammed into normal-like states. See the mechanism in this peer-reviewed study: pubmed.ncbi.nlm.nih.gov/3966… #CancerResearch #PeerReviewed #AdvancedScience #CellReprogramming #FutureOfMedicine

What immune cell type was once considered too difficult to generate through transcriptional reprogramming alone — until combinatorial TF screening changed the game? medium.com/@harryblackwood/d… 🧠 We break down how platforms like REPROcode uncover hidden transcriptional “recipes” for immune cell fate control, from dendritic cells to beyond. 📖 Read the full blog to see how TF hierarchies, stoichiometry, and scalable screening are reshaping immunotherapy research. 🔍 Doing related research? Explore the literature faster with PubMed.ai — your shortcut to high-impact biomedical insights. #Immunology #CellReprogramming #TranscriptionFactors #SingleCell #Immunotherapy #PubMedAI

A Combinatorial Transcription Factor Screening Platform for Immune Cell Reprogramming Find More Research: pubmed.ai/?utm_source=X&utm_… Immune cell identity and function are tightly governed by transcription factor (TF) networks. However, identifying which combinations of TFs can reliably reprogram immune cells has remained a major bottleneck. This study introduces an advanced combinatorial TF screening platform, exemplified by REPROcode, designed to systematically map transcriptional control in immune cells. By testing TF combinations at scale, the platform reveals optimal regulatory circuits capable of reshaping immune cell phenotypes. Key highlights: - Enables high-throughput discovery of functional TF combinations - Dissects transcriptional networks underlying immune cell plasticity - Provides a scalable framework for immune cell reprogramming By moving beyond single-factor perturbations, this approach opens new avenues for precision immunotherapy, cell-based treatments, and rational immune engineering. #Immunology #TranscriptionFactors #CellReprogramming #Immunotherapy #SystemsBiology #BiomedicalResearch

THE HIDDEN FREQUENCIES OF HUMAN HEALING! SCIENTISTS AT MED BED RESEARCH DIVISION REVEAL THAT EVERY HIDDEN ORGAN IN YOUR BODY CARRIES ITS OWN ENERGETIC SIGNATURE — A FREQUENCY THAT DECIDES WHETHER YOU THRIVE OR DECAY. WHEN THOSE TONES FALL SILENT, DISEASE BEGINS. WHEN THEY AWAKEN — REGENERATION STARTS. 🧬 PANCREAS: 364 HZ — STABILIZES INSULIN FLOW AND RESTORES INNER ENERGY BALANCE 🫁 THYMUS GLAND: 432 HZ — REACTIVATES IMMUNITY AND CELLULAR MEMORY 🧠 HYPOTHALAMUS: 852 HZ — REWIRES STRESS RESPONSE AND HORMONE ALIGNMENT 🩶 ADRENAL GLANDS: 336 HZ — DISSOLVES FATIGUE AND RESTORES NATURAL VITALITY 🫀 GALLBLADDER: 281 HZ — BREAKS DOWN TOXICITY AND EMOTIONAL STAGNATION 🧫 COLON: 176 HZ — CLEANSES STORED TRAUMA AND REGENERATES GUT FLORA EVERY PULSE, EVERY VIBRATION, CARRIES INFORMATION. ⚡ YOUR BODY IS AN INSTRUMENT — TUNE IT BACK TO ITS ORIGINAL FREQUENCY. ENTER THE QUANTUM FIELD ⬇️⬇️⬇️ t.me/MrPool_Q #MEDBED #QUANTUMHEALING #IONICCARE #TESLAFREQUENCY #DNARESET #CELLREPROGRAMMING #SCALARTECHNOLOGY #BIOFIELD #ENERGYMEDICINE #QUANTUMSCIENCE

Honored to be part of the "Reprogramming Stars" interview series by Filipe Pereira @CellReprogramming. Humbling title but very fun discussion about past and ongoing research, future directions, advice to young trainees and more. Check it out! liebertpub.com/doi/10.1177/2…

📗From PCP recent issue (66-4): Regular Paper💐 '#Auxin fluctuation and PIN polarization in moss leaf cell reprogramming' Han Tang et al. doi.org/10.1093/pcp/pcaf008 #Physcomitriumpatens #CellReprogramming #Plantsci

Advances in transcription factor delivery: Target selection, engineering strategies, and delivery platforms. | In-San Kim @KISTKOREA | @KoreaCRS [Open Access] #TranscriptionFactor #CellReprogramming kwnsfk27.r.eu-west-1.awstrac…

Join us on April 4 at 11:00 for a @DKFZ Distinguished Lecture by Filipe Pereira from @lunduniversity: "In Vivo Dendritic Cell Reprogramming for Cancer Immunotherapy" 📍DKFZ Lecture Hall, Heidelberg @CellReproLab is pioneering #cellreprogramming to evolve #cancer #immunotherapy.

Academy President Nir Barzilai (@NirBarzilaiMD) and member Juan Carlos Izpisua Belmonte spoke at the inaugural Vatican Longevity Summit, a landmark event in Rome that brought together scientists, Nobel Laureates, and global leaders to tackle one of the most pressing challenges of our time: ensuring that longevity is accompanied by quality of life. This initiative, sponsored by the Pontifical Academy for Life, is aligned with the Milan Longevity Summit, a global event organized in 2024 by BrainCircle Italia. The Vatican Longevity Summit was conceived by Carrara Alberto (@CarraraNeuro), President of the International Institute of Neurobioethics (@iinbeneuro), and Viviana Kasam, President of BrainCircle Italia (@ItaliaBrain), who sadly passed away in October 2024. Designed as the first international event within the framework of the Jubilee of Hope, the summit marks the beginning of a global initiative focused on the future of aging. During the event, Juan Carlos Izpisúa Belmonte also led a roundtable discussion on the biological mechanisms of aging and disease, highlighting how functional decline in tissues and organs contributes to age-related health deterioration. He explored various interventions aimed at delaying aging and extending healthspan, with a focus on epigenetic regulation—specifically DNA methylation, histone modification, chromatin remodeling, and non-coding RNAs. Belmonte emphasized the potential of cellular rejuvenation through partial reprogramming with Yamanaka factors, discussing how this approach could restore cell health, enhance resilience, and offer new therapeutic avenues for reversing disease, injury, and age-related disabilities. #VaticanLongevitySummit #LongevityScience #HealthyAging #Epigenetics #CellReprogramming #Neurobioethics #PontificalAcademy #MilanLongevitySummit #BrainCircleItalia #JubileeOfHope #RegenerativeMedicine

Cell Fate Changes – How Transcriptional Memory Affects Reprogramming 🧬 👉t1p.de/43yrw A team led by Dr. Eva Hörmanseder and Dr. Antonio Scialdone, #HelmholtzMunich, has identified key factors that limit nuclear reprogramming – the process of transforming one cell type into another. 💡 While promising for regenerative medicine, reprogramming often leads to dysfunctional cells. Key Findings: 🌟Some cells retain a "memory" of their original identity, resisting transformation. 🌟Certain genes linked to the original cell type hinder reprogramming success. 🌟Suppressing these genes improves reprogramming efficiency and cell functionality. These insights could enhance cell-based therapies for conditions like organ failure and neurodegenerative diseases, and regenerative medicine. #CellReprogramming #Epigenetics #StemCells #RegenerativeMedicine #NeurodegenerativeDiseases

🚅Advance Access: How polarized tissue repair is achieved upon excision? Using a bryophyte Physcomitrium patens, Han Tang et al. revealed that the proper polarization of PIN-FORMED #auxin exporter is a key process🔑 doi.org/10.1093/pcp/pcaf008 #cellreprogramming #plantsci

🦠 We’re looking for a PhD student to join the #cellreprogramming project led by Andrzej Mizera, PhD. EdgeCR is a multidisciplinary research project to be carried out at IDEAS NCBR in collaboration with @uni_lu Co-financed by @NCN_PL ideas-ncbr.pl/en/phd-student…

Article link: lifespan.io/news/study-of-di… New study sheds light on #CellReprogramming: 🧬 Researchers reveal that nearly all reprogrammed neurons derive from rare neural crest stem cells (NCs) in the skin, not mature fibroblasts. This challenges views of fate conversion across germ layers, suggesting directed differentiation of NC precursors with an intrinsic neuronal bias. A key insight into efficiency & mechanisms! 🧠✨ #StemCells #Biotech

3/4 We also observed striking reprogramming of neural crest cells to a mesoderm-like state, resulting in ectopic fins throughout the body. EWSR1::FLI1 hijacked the developmental program that included activation of HOX genes and FGFR signaling cascades during the formation of ectopic fins. Given that human Ewing sarcoma growth is significantly influenced by FGF signaling, we suggest that EWSR1::FLI1 may foster a favorable local signaling environment for tumor growth. #CellFate #CellReprogramming

📢 The Pereira Lab is hiring 2 researchers with an MSc to join the Cintech project! ➡️ Join us to advance our projects at the interface of #CellReprogramming and #Cancer #Immunotherapy 📥 Apply here until 20th of November: forms.gle/Mwr73PZcnaedNdmv7

#SyntheticEmbryo R&D In Regenerative Medicine & Developmental Biology - Dr. Jacob Hanna, MD, Ph.D., #WeizmannInstitute of Science #Embryology #Embryo #StemCells #CellReprogramming #Cloning #ArtificialWombs #RegenerativeMedicine #Health #Aging #Longevity #Biotech #Biology #STEM