Supply chains break down — iodine deficiency.
Production lines overfill — colloid-rich follicles.
Mosaic everywhere. The thyroid really is nature’s geometry experiment, like a mathematician on caffeine. #Endocrinepath#surgipathology#Digitalpath #MedEd#LeilaBerhanuPathNotes

🧂🧂 Thyroid mass 52/F HE IHC images #pathtwitter #pathtweetaward #endocrinepath

Now there are 3. Thyroid neoplasms harboring a novel OCLN::PRKCI gene fusion doi.org/10.1016/j.humpath.20… doi.org/10.1016/j.modpat.202… #EndocrinePath #moldx #molpath

#PathQuiz 🔬🦋 #EndocrinePath _____________ thyroid carcinoma A) Papillary B) Anaplastic C) Follicular D) Medullary #Pathology #EndocrinePath #Thyroid

❄️ Frozen to Final: Diagnostic Correlation Case: 75M with massive compressive thyroid mass (9 cm) with tracheal invasion 🧊 Frozen: Malignant tumor (subtype deferred) 💎 Final diagnosis: Medullary Thyroid Carcinoma 🔬 Key features: • Nests, trabeculae, cords • Polygonal cells, granular cytoplasm • Salt & pepper chromatin • Lymphovascular invasion 🧪 IHC: Calcitonin , CEA , Synapto , Chromogranin , INSM1 CK7 , CK20-, TTF1 (diffuse) Thyroglobulin–, PAX8–   🧬 Molecular: • Activating RET mutations in majority (germline in hereditary cases – MEN2A/MEN2B; somatic in sporadic) • RAS mutations (HRAS/KRAS) in RET–negative tumors • Routine: recommend RET mutation testing ± germline screening (important for family counseling)   📊 Prognosis: • Variable; worse with: Older age, large tumor, extrathyroidal extension (like tracheal invasion here) and distant metastasis • 10-year survival ~70–80% overall, but ↓ significantly in advanced disease • Calcitonin doubling time = key prognostic marker   💡 Pearl: When morphology & clinical picture mismatch on frozen → call “malignant” & defer typing. IHC serum calcitonin clinches MTC. #PathTwitter #Surgpath #EndocrinePath #ThyroidPath #MedullaryThyroidCarcinoma #FrozenSection #Histopathology #Pathology Case courtesy @annsmiley78

60s F w/ hyperparathyroidism. parathyroid nodule. Dx? #EndocrinePath #HeadandNeckPath #PathX #PathTwitter

60s F 5cm hypoechoic thyroid nodule. Dx? #HeadandNeckPath #EndocrinePath #PathX #PathTwitter

#Neuropath #EndocrinePath

Well said! Truly deserved — it’s wonderful to see Dr. LiVolsi honored for her amazing contributions and lasting legacy in pathology!

Wonderful way to honor Dr LiVolsi @PennPathLabMed @NayarRitu @EndocrinePath

What’s in a name? New meta-analysis of DNA methylation data shows pituitary “adenomas” share more patterns with NETs than with adenomas - backing the PitNET terminology and reshaping how we classify these tumors. #PathTwitter #EndocrinePath link.springer.com/article/10…

Metastatic papillary thyroid carcinoma to the kidney #GUpath #EndocrinePath #ENTpath ➡️Metastatic PTC to the kidney is exceptionally rare, with < 50 cases reported ➡️May present as solitary or bilateral renal masses, often mimicking primary renal tumors ➡️Nuclear grooves/pseudoinclusions and colloid in this tumor ➡️The presence of renal metastasis generally indicates advanced disease and may be associated with a poorer prognosis (PMIDs: 28588771; 28242987)

30/F thyroid nodule.. 👀👁️ #pathtwitter #headandneckpath #endocrinepath

👉 26 YO male underwent total thyroidectomy. What is your diagnosis? What may be the underlying genetic pathology? #PathTwitter #endocrinepath #Surgpath #Pathology #Pathresidents

📣 Adrenal Adenoma – Cushing Syndrome (Pediatric Case) 👉 🧒🏼 12-year-old male with classic Cushingoid features. 📌 Gross features: •Well-circumscribed, solitary adrenal mass •Yellow to golden-brown cut surface •Sharp demarcation from normal adrenal cortex 📌 Microscopy: •Sheets/nests of polygonal cells with clear to eosinophilic cytoplasm •Minimal nuclear atypia, no necrosis or atypical mitoses •Adjacent adrenal cortex shows atrophy due to cortisol excess 📌 Clinical relevance: •Rare but important cause of endogenous Cushing syndrome in children •Complete excision is usually curative #PathTwitter #AdrenalTumor #CushingSyndrome #PediatricPathology #EndocrinePath

🚨 New in @EndocrinePath! Survival in PanNETs G2a vs G2b isn't the same! 10-yr OS:
🟩 G1 (<3% Ki-67): 81%
🟨 G2a (3–<10%): 68%
🟥 G2b (10–20%): 44%
🖤 G3 (>20%): 23% Splitting G2 matters for prognosis and management! Details here 👉 link.springer.com/article/10…

Another thyroid specimen with a stunning image and precise annotations. ✍️🧬 #EndocrinePath #ENTpath #PathTwitter 15/

Can AI help tackle the diagnostic challenges of NIFTP in thyroid pathology? A new study proposes a 3-stage deep learning pipeline - showing promise, but with key hurdles ahead. 🧠🔬 Read more in @EndocrinePath link.springer.com/article/10…

What a fantastic #pathCast session with Dr. @DrJuhlin from Karolinska University on adrenal tumors! He covered everything from histology to molecular updates. YouTube: youtube.com/watch?v=dmEIUz2C… #Pathology #Adrenal #MedicalEducation #EndocrinePath #MedicalEducation #EndocrinePath

#ENDOCRINEPATH ADRENAL CHRONICLES: FROM SLIDES TO SEQUENCING ( Dr. @DrJuhlin , Associate Professor of Experimental Pathology, @karolinskainst Sweden ) 🗓️ June 11, 2025 - 12:00 PM (ET, NYC) Livestream links : YouTube: youtube.com/@pathCast Facebook: m.facebook.com/pathCast/