As @Cambridge_Uni PI, I am delighted to have contributed to the @MsStat2 trial on simvastatin for secondary progressive MS.
It highlights the REAL challenges of running efficacy trials in progressive MS.
#ClinicalTrials #ProgressiveMS
thelancet.com/journals/lance…
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7 Dec 2024
Just had confirmation that I was given a placebo whilst I was on the #MSstat2 trial.
mssociety.org.uk/research/ex…
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20 Sep 2024
Despite the disappointing result, @MsStat2 had so many positives. Remaining active during the pandemic, often being the only contact people with MS had with HCP’s to name but one.
Onwards and upwards now with OCTOPUS!🐙
20 Sep 2024
Today the results of the MS-STAT2 trial were announced by Professor Jeremy Chataway at the ECTRIMS research conference in Copenhagen.
This trial tested simvastatin, commonly used to treat high cholesterol, in 964 people with secondary progressive MS. (1/6)
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20 Sep 2024
Very disappointing news but an enormous thank you to all those who worked so hard to keep the trial going during such difficult times. Professor Jeremy Chatterway - this would not have been possible without your leadership.
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20 Sep 2024
Taking into account both @MsStat2 and #Tolebrutinib #HERCULES trials @ECTRIMS #MSCopenhagen24 the role of #brain #volume change/#atrophy as predictor of treatment effect in #MS deserves some reflection @mssociety @mssocietyuk @NIHRresearch @the_MSBlog
20 Sep 2024
@MsStat2 is NEGATIVE. Big thank you commiserations to ALL involved @UCLIoN @QSMSCENTRE and across sites. Monumental effort & reminder how difficult progressive #MS treatment is, how slowly progress is being made. Thanks for support: @mssociety @mssocietyuk @NIHRresearch
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20 Sep 2024
@MsStat2 is NEGATIVE. Big thank you commiserations to ALL involved @UCLIoN @QSMSCENTRE and across sites. Monumental effort & reminder how difficult progressive #MS treatment is, how slowly progress is being made. Thanks for support: @mssociety @mssocietyuk @NIHRresearch
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20 Sep 2024
🚨 Moment of truth approaching - results of the @MsStat2 @mssocietyuk trial to be published NOW @ECTRIMS #MSCopenhagen24 @themsguide @MarkWebb_ @griffax09 @RachelHorne19 @aid4disabled @drbarrysinger @C_OrejaGuevara @AaronBosterMD @prof_mouse @the_MSBlog
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Delighted to have contributed to the
@MsStat2 phase III trial and excited to hear what this was about #progressiveMS #stopMS #ECTRIMS2024
pubmed.ncbi.nlm.nih.gov/3928…
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16 Jul 2024
Going to be high noon @ECTRIMS #ECTRIMS2024 Copenhagen - @MsStat2 #Tolebrutinib #GFAP #Neurofilaments #EBV all on the agenda @GavinGiovannoni @themsguide @AaronBosterMD @drbarrysinger
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22 Feb 2024
One of the benefits of being on the MSstat2 trial was that you're cognitive skills are assessed. Sadly most Neuro's just won't have the time to fit everything in during an annual check up.
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18 Nov 2023
Anybody out there? What is happening with Ibudilast? multiple-sclerosis-research.… @mssociety @mssocietyuk @MSTrust @MsStat2 @QSMSCENTRE
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21 Oct 2023
I've been on the @MsStat2 trial & started the #ChariotMS trial in June. There is no DMT to slow down my progression (no active lesions) so I feel I've nothing to lose. Also if on med or placebo,I hope it will help future PwMS.
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3 Aug 2023
For me yes 😉 The MS Stat 2 trial. Penultimate appointment xx
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7 Jul 2023
Thank you @StuStepsUp Marie for inspiring work @mssocietyuk @mscymru Ambassadors for people with #MS #AdvancedMS Check out chariotms.com #ChariotMS @QSMSCENTRE @MsStat2 @OctopusTrial @AttackMS_trial @the_MSBlog #MS @RachelHorne19 @themsguide @aid4disabled #NHS75 #GIG75
5 Jul 2023
Recently retired nurse & general manager and MS ambassador @StuStepsUp talks candidly about his experience of working in the NHS with MS over the last 40 years and how demand has changed vastly over that time.
#NHS75 #GIG75
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12 Jun 2023
Thank you. I was fine starting the MSstat2 trial few years back, as that was only possibly taking just a statin. Think more anxious as to the type of drug I could be potentially taking. All good though so far,still no side effects.
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10 Jun 2023
@iluvdolcecoffee This will be good to watch so you can get an idea of what's involved.
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