Yesterday, on World MS Day, we recognize the more than 2.9 million people worldwide living with multiple sclerosis, with particular attention to those affected by progressive forms of the disease. Progressive MS has historically had significantly fewer treatment options than relapsing MS, underscoring the need for continued treatment in this area. Ibudilast has been investigated as a potential therapy to address this unmet need. In the SPRINT-MS Phase 2 clinical trial, published in the New England Journal of Medicine in 2018, ibudilast was associated with a 48% reduction in the rate of brain atrophy compared with placebo over 96 weeks, corresponding to approximately 2.5 mL less brain tissue loss. The study enrolled 255 patients with primary or secondary progressive MS across 28 clinical sites in the United States. While scientific progress is often incremental, each well-conducted study advances our understanding and brings us closer to better options for people living with MS. 🔗 Read the full SPRINT-MS publication: nejm.org/doi/full/10.1056/NE… #MediciNova #WorldMSDay #MSAwareness #MultipleSclerosis #ProgressiveMS #Ibudilast

Congrats to Lars Bø & colleagues for the SMART-MS trial — intrathecal mesenchymal stem cells in #progressiveMS neurology.org/doi/10.1212/WN… Also read our editorial with @sabahmozafari neurology.org/doi/10.1212/WN… #StemCells

GOING LIVE in 2 hours - Cemcat International Rounds, "Treatment of Progressive Disease" Prof. Daniel Ontaneda (Professor of Neurology, Cleveland Clinic Lerner College of Medicine, Cleveland, USA) - a leading voice in progressive MS trials - breaks down what the current evidence shows and where the unmet needs remain. 🗣️ Chair: Prof. Xavier Montalban (Neurologist - Professor of Neurology - Multiple Sclerosis Centre of Catalonia (Cemcat), UVic-UCC, Barcelona) 🔴 Today | 16:00 - 17:00h (CEST) ➡️ Tune in: bit.ly/CIR2026 #CIR26 #CemcatInternationalRounds #ProgressiveMS #MSResearch

🎉 Thrilled that @mssocietyuk has renewed funding for the @CentreMyelin for 5 more years! Honoured to co-direct with @ThoraKaradottir & Alasdair Coles as we push to find effective myelin repair therapies for #progressiveMS. The work continues! 💪 mssociety.org.uk/research/la…

realtalkms.com/452 🇪🇺 New hope for people with non-relapsing SPMS in Europe— We explain the latest developments on RealTalk MS. 🎧 #MultipleSclerosis #MSCommunity #MSAwareness #RealTalkMS #ProgressiveMS

Progressive MS: once called untreatable. The evidence landscape has shifted - but questions remain 🧬 bit.ly/CIR2026 📘 Next Monday, May 4th at (CEST) - new Cemcat International Rounds session: "Treatment of Progressive Disease" 👨🏼‍⚕️ Dr. @DanOntaneda (Associate Professor of Neurology, Cleveland Clinic Lerner College of Medicine, Cleveland, USA) - leading investigator in progressive MS clinical trials - presents the current evidence and open challenges in treatment of progressive disease. 🗣️ Chaired by Prof. @XMontalban - Neurologist - Professor of Neurology - Multiple Sclerosis Centre of Catalonia (Cemcat), UVic-UCC, Barcelona ➡️ Save your spot and register free: bit.ly/CIR2026 #CIR26 #CemcatInternationalRounds #ProgressiveMS #MSResearch

March is #MultipleSclerosisAwarenessMonth At MediciNova, we honor this month by reaffirming our commitment to advancing research that may improve outcomes for people living with multiple sclerosis (MS). #MediciNova #MultipleSclerosis #ProgressiveMS #ClinicalResearch #MNOV

realtalkms.com/444 Three new studies funded by the International Progressive MS Alliance are targeting some of the most common MS symptoms. ⭐ Discover what researchers are learning on RealTalk MS. #MultipleSclerosis #MSResearch #ProgressiveMS

realtalkms.com/444 Ozempic. Wegovy. Mounjaro. Zepbound. What if a GLP-1 drug could do more than treat diabetes and support weight loss? What if one could impact progressive MS? We’re breaking down the science on this week’s episode of #RealTalkMS. 🎧 #MultipleSclerosis #ProgressiveMS @EllenMowryMD

We zijn binnen voor #UTRgen De kou is een hel voor iemand met #progressiveMS Links staan in mijn andere post. Of scan de QR! #HelpDenise aan #HSCT @DeniisedG @fcutrecht vs @KRCGenkofficial

Excited to speak at the first of the 2026 @TheMilnerInst Seminar Series on neurodegeneration! 🎉 I'll be presenting “Advanced Stem Cell Technologies for MS Research and Cure.” Can’t wait to engage with everyone! #Neurodegeneration #Research #progressiveMS

✨ Had a fantastic experience speaking at the Cell Press Beijing Conference 2025 on 'Cell and Gene Therapies for Neurological Conditions'! 🌟 Engaging with cutting-edge science and inspiring discussions was a privilege #neuroscience #progressiveMS

realtalkms.com/430 Repurposing existing drugs could change the future of MS treatment. We’ll tell you how to catch the Progressive MS Alliance webcast replay on RealTalk MS. 🎧 #MultipleSclerosis #ProgressiveMS #RealTalkMS

realtalkms.com/429 Today: The International Progressive MS Alliance webcast, How Existing Drugs Could Transform MS Treatment. Big conversations, big insights! 🌍 #MultipleSclerosis #ProgressiveMS #MSResearch

Multiple sclerosis (MS) is a chronic, progressive disease of the central nervous system that affects nearly 2.5 million people worldwide. While advances have improved treatment for relapsing-remitting MS (RRMS), options for patients living with progressive MS remain extremely limited. Through collaborative trials with the NIH, Cleveland Clinic, and leading MS research centers, MN-166 has advanced as a potential disease-progression modifying therapy. Our mission remains clear: to pioneer safe, effective, and well-tolerated therapies that provide new hope to patients facing the toughest forms of MS. Learn more: medicinova.com/clinical-deve… #MediciNova #MultipleSclerosis #ProgressiveMS #ClinicalResearch #Biotechnology #Neuroscience

Delighted to see this out in @NeuroCellPress!!! Together with @BeermanHSCaging (& many other friends) we identify disease-associated radial glia-like cells (#DARGs) that fuel #inflammation and #neurodegeneration in #progressiveMS cell.com/neuron/fulltext/S08…

As @Cambridge_Uni PI, I am delighted to have contributed to the @MsStat2 trial on simvastatin for secondary progressive MS. It highlights the REAL challenges of running efficacy trials in progressive MS. #ClinicalTrials #ProgressiveMS thelancet.com/journals/lance…

The resource is one of the largest collections of MS data ever assembled. See how its large pool of anonymized data will help researchers worldwide better understand MS progression: bit.ly/45DhEld #MS #MSResearch #MSTreatment #MSNews #ProgressiveMS #PPMS #EndMS #Bionews

🔬 A new milestone in progressive MS research has been reached. The International Progressive MS Alliance, in partnership with McGill University and leading pharma, has launched the MS Clinical and Imaging Data Resource (CIDR), a €685M collection of 72,000 MRI scans and 200,000 clinical records. 📖 Read full article at eMedEvents to know more: ow.ly/jEjB50WJr8j For neurologists, nurses, and MS researchers, CIDR offers harmonized datasets to study disease progression, test predictive AI tools, and design more efficient clinical trials. This initiative aims to close the treatment gap in progressive MS and bring therapies to patients faster. Credit: @mssociety #MultipleSclerosis #ProgressiveMS #McGillUniversity #Neurology #MSResearch #Healthcare #eMedEvents #emednews #meded

#Stress isn’t just bad for my #MS it’s tried to kill me. medical #gaslighting, and a dark room I call my bunker. But I’m still here. Still fighting. Still telling it how it is. #multiplesclerosis #Disability #chronicillness #mentalhealth #progressivems tinyurl.com/y9b2p6bh