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Precision dosing of recombinant vaccinia vaccine via pillar-guided microneedle patch confers SARS-CoV-2 immunity 柱ガイド型マイクロニードルパッチによる組換えワクチニアワクチンの精密投与がSARS-CoV-2免疫を付与する SARS-CoV-2のスパイク遺伝子を載せた組換えワクチニアウイルスワクチン(r-DIs-S)を、溶解型マイクロニードルパッチで届ける方法を開発した研究報告。 3Dプリントした柱がワクチンを針先に集中させ、1枚あたり約9.4±1.8×10^6 PFUを精密に搭載できた。 乾燥も速く、針先への搭載効率は16.5%(従来2.0%)に向上し、作製後も感染性は約50%保たれた。 マウスでは5分貼付するパッチ2枚と4週目の追加接種で、スパイク特異的IgGと中和抗体が強く誘導された。 致死量のSARS-CoV-2感染でも全例が生存し、肺のウイルス量と病変が減り、体重も保たれた。 Using 3D-printed pillars, a dissolving microneedle patch precisely loaded a recombinant vaccinia vaccine (r-DIs-S) onto needle tips, improving drying and preserving viral activity. In mice, brief patch application plus a booster triggered strong spike-specific antibodies and neutralization. Vaccinated animals survived lethal SARS-CoV-2 challenge with reduced lung virus and milder lung damage. nature.com/articles/s41598-0… #マイクロニードルパッチ #ワクチニアウイルスベクター #SARSCoV2免疫 #Microneedlepatch #Vacciniavector #SARSCoV2immunity
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11 Sep 2024
Fabrication of an effective hydrogel #MicroneedlePatch (MNP), loaded with #StemCell-derived, mitochondria-rich #ExtracellularVesicles, enables gradual release and delivery of mitochondria into the wound tissues, boosting #WoundHealing. #OpenAccess: go.acs.org/aOf
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‼️“Microneedle Patch“ Das Impf-Pflaster für Kinder‼️ Ein Gamechanger?! Auf jedenfall. Eine neue Studie (Phase1/2) in @Thelancet (doppelblind,randomisiert) zeigt dass die Anwendbarkeit easy, die Resorption gut und das Nebenwirkungs Profil extrem klein ist. Wenn sich das bestätigt wäre das ein Riesenschritt mehr Kinder zur Impfung zu bringen. Nebenbei wird das eine nervliche Entlastung für Eltern und Ärzte! #Kinderimpfung #impfenRettetLeben #impfenschuetzt #protectthekids #MicroneedlePatch thelancet.com/journals/lance…
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Replying to @G11Sven
1/- Toevallig hadden @EtienneJansen en ik gisteren contact over de #MicronaaldPleister aKa #MicroneedlePatch, een kort onderzoek hierna levert de volgende resultaten. Nb.: de links willekeurig 2017 ~ Emory University ~ Georgia Institute of Technology 👉🏻 web.archive.org/web/20180109…

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21 Dec 2022

7 Dec 2021
It's almost like the world is being conditioned for that time period that's coming in Revelation 13:16-18 (future events) where you'd have a mark in your right hand or forehead to buy and sell (live normally). Are there any signs of this? 2/
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15 Dec 2022
Engineers at the @UCSanDiego have developed a prototype of such a wearable that can continuously monitor several health stats. wevolver.com/article/multi-t… #wearable #healthcare #technology #engineering #stem #innovation #monitor #MicroneedlePatch

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4 Oct 2022
The quantum-dot tattoo in the skin could be scanned as "proof of vaccination" which may be tied to a digital economic system. They're paving the way for something... #cryptocurrency #vaccines #microneedlepatch #mRNA #InjectableElectronics #GeneEditing
7 Dec 2021
It's almost like the world is being conditioned for that time period that's coming in Revelation 13:16-18 (future events) where you'd have a mark in your right hand or forehead to buy and sell (live normally). Are there any signs of this? 2/
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6 Jul 2022
Engineers at the @UCSanDiego have developed a prototype of such a wearable that can continuously monitor several health stats. wevolver.com/article/multi-t… #wearable #healthcare #technology #engineering #stem #innovation #monitor #MicroneedlePatch

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Core-shell microneedle patch for six-month controlled-release contraceptive delivery. | Mark R. Prausnitz @GTChBE | @CRS_FG_SkinMuco #microneedlepatch #contraceptivedelivery #controlledrelease doi.org/10.1016/j.jconrel.20…

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Dem Moderna Impfstoff hat man eine PCR Tracing Sequenz eincodiert. Ein passender PCR Marker existiert ebenfalls. Ich erinnere an das Particles fir Humanity Projekt und Impfstoff Tracking Patent. Für das braucht es nur noch das passende Nadel Gel Kissen. #MicroNeedlePatch
PCR primers that detect the vax mRNA. It doesn’t appear they tested their cross reactivity against C19. The mRNA-1273 RNA ended up in the lipid fraction of the milk. You can thank the N1-methylpseudouridine for that. jamanetwork.com/journals/jam… medrxiv.org/content/10.1101/…
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21 Jan 2022
As for #Gates, let's just say he's very invested. From jabs to microneedle patches. #microneedlepatch #quantumdots #GeneticManipulation
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17 Jan 2022
A system of "verification" is coming to prevent stuff like this ⬇️. How convenient, just in time for their 2022 Phase 1 Human trials. #microneedlepatch #quantumdots #mark #verification #NIH #MIMIX

17 Jan 2022
A nurse was arrested in Palermo, Sicily, for allegedly pretending to administer a COVID-19 vaccine to consenting patients. Video surveillance footage appears to show the nurse emptying the content of a syringe into a gauze before giving the injection.
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New research article> Safety and dose-sparing effect of #JapaneseEncephalitis #vaccine administered by #MicroneedlePatch in uninfected, healthy adults (MNA-J): a randomised, partly blinded, active-controlled, phase 1 trial thelancet.com/journals/lanmi… #JapaneseEncephalitisVirus #JEV

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Today's edition of The Tribune, a daily aggregation about genetics, genealogy, life and physical sciences, and more: thetribune.news/?edition_id=… A thank-you to @sciencetracker2 @sciam @DailyScan #geneexpression #microneedlepatch

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Development of a thermostable oxytocin microneedle patch. | Mark R. Prausnitz @GTChBE | @CRS_FG_SkinMuco #microneedlepatch #transdermal #peptidestability #oxytocin [50 days' free access] authors.elsevier.com/a/1dQUe…

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Microneedle Patch Delivers Antibiotics Locally in The Skin Source: Karolinska Institutet 📷 Jill Ziesmer, Karolinska Institutet #health #news #microneedlepatch #skin #antibiotics #injections #bacterialstrains #mrsaskininfections #karolinskainstitutet news.ki.se/microneedle-patch…
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