Applications have their own settings :) You can also ask 2 and 3 mm WD objectives :) Will there be miniscopes with even higher NA objectives? @TRANSVISTA #2p #mini2p #CaImaging

❤️‍🔥TRANSVISTA 2025 | Our Word of the Year: 𝐂𝐨𝐧𝐭𝐫𝐢𝐛𝐮𝐭𝐢𝐨𝐧 In 2025, 𝐜𝐨𝐧𝐭𝐫𝐢𝐛𝐮𝐭𝐢𝐨𝐧 guided everything we did: ✔️ 𝟐𝟎 peer-reviewed publications enabled by TRANSVISTA research and technology. ✔️ 𝟏𝟎 international scientific meetings supported, including SfN, GRC, and Cold Spring Harbor meetings etc. ✔️ Global on-site support and training delivered by our application scientists and engineers. Looking ahead to 2026, we 𝐤𝐞𝐞𝐩 𝐦𝐨𝐯𝐢𝐧𝐠 𝐟𝐫𝐞𝐞𝐥𝐲. #Contribution #Neuroscience #Imaging #mini2P

🔬 Breakthrough in Brain Imaging: The World's First 1g-Class Compound Metalens Miniature Two-Photon Microscope! We're thrilled to announce a significant leap forward in miniaturized brain imaging technology: the 𝐌𝐞𝐭𝐚-𝐦𝟐𝐏𝐌 𝟐.𝟎. Weighing only 𝟏.𝟎𝟔 𝐠𝐫𝐚𝐦𝐬, this second-generation compound metalens-based miniature two-photon microscope achieves 𝐡𝐢𝐠𝐡-𝐒𝐍𝐑, 𝐥𝐚𝐫𝐠𝐞-𝐟𝐢𝐞𝐥𝐝-𝐨𝐟-𝐯𝐢𝐞𝐰 𝐢𝐦𝐚𝐠𝐢𝐧𝐠 𝐨𝐟 𝐧𝐞𝐮𝐫𝐨𝐧𝐚𝐥 𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐲 𝐢𝐧 𝐟𝐫𝐞𝐞𝐥𝐲 𝐛𝐞𝐡𝐚𝐯𝐢𝐧𝐠 𝐦𝐢𝐜𝐞. This collaborative work, led by teams from Beijing Information Science & Technology University, Harbin Institute of Technology, Peking University, and Beihang University, is now published in #PhotoniX. 𝐖𝐡𝐲 𝐢𝐬 𝐭𝐡𝐢𝐬 𝐚 𝐠𝐚𝐦𝐞-𝐜𝐡𝐚𝐧𝐠𝐞𝐫? Existing high-performance miniature microscopes often face a critical trade-off: excellent imaging capability comes with a weight penalty (>2g), limiting their use in weight-sensitive animals like songbirds, bats, and pups. While metalenses offered a lightweight promise, single-layer designs struggled with limited field-of-view and off-axis aberrations. Our Solution: A "Two-Stage Imaging" Compound Metalens Architecture By decoupling the scanning and focusing functions using a novel dual-layer metalens design, we broke the traditional balance between weight, FOV, and resolution. 𝐊𝐞𝐲 𝐀𝐜𝐡𝐢𝐞𝐯𝐞𝐦𝐞𝐧𝐭𝐬 𝐨𝐟 𝐌𝐞𝐭𝐚-𝐦𝟐𝐏𝐌 𝟐.𝟎: ▪️ Ultralight Weight: Probe head at 1.06g (lens weight reduced to 1/10 of conventional designs). ▪️ Large FOV: 350×330 µm², a >50x improvement over the first generation. ▪️ High Resolution: 1.17 µm laterally, maintaining >80% resolution even at the FOV edge. ▪️ High Stability: 90% field displacement <5 µm during short-term tests, enabling reliable long-term tracking of the same neurons across days in freely moving mice. This work successfully transitions metalens technology from a lab concept to a practical tool capable of supporting high-quality, natural-behavior brain function imaging. Looking ahead, this technology paves the way for free-behavior multicolor imaging, multi-region synchronous observation, and cross-species neural circuit studies, with potential impacts on understanding brain cognition, early disease diagnosis, and neuropharmaceutical evaluation. Huge congratulations to the entire team, especially first authors Zeyu Hao and Yao Zhang, and corresponding authors Prof. Runlong Wu, Prof. Shumin Xiao, and Prof. Aimin Wang. Read the full paper in PhotoniX: doi.org/10.1186/s43074-025-0… Learn More about TRANSVISTA: transvista.com #Neuroscience #BrainImaging #TwoPhotonMicroscopy #m2PM #mini2P

💡 A recent study conducted by Dr. Yaning Han and Dr. Pengfei Wei presents new methodologies that serve as a powerful tool for investigating how brain activity corresponds to behavioral states. This research lays the foundation for future studies on naturalistic neural coding principles and was published in the latest issue of JoVE. Discover the full study: DOI: 10.3791/68668 The researchers developed a framework to capture and decode behavioral and neuroimaging data from freely moving animals in naturalistic experimental environments. 𝐂𝐨𝐦𝐩𝐨𝐧𝐞𝐧𝐭𝐬 𝐨𝐟 𝐅𝐫𝐚𝐦𝐞𝐰𝐨𝐫𝐤 – ▪️ SBeA (Social Behavior Atlas) - deep learning-based pose estimation and behavior classification methods, ▪️ mTPM – miniature 2-photon fluorescence imaging techniques (by TRANSVISTA, formerly known as Transcend Vivoscope). ▪️ CEBRA (Consistent EmBeddings of high-dimensional Recordings using Auxiliary variables) - a contrastive learning-based neuroethological embedding algorithm, 𝐅𝐫𝐚𝐦𝐞𝐰𝐨𝐫𝐤 – ▪️ Utilizes deep learning-driven pose estimation to ensure accurate monitoring of body positions. ▪️ Facilitates high-resolution, contrast-enhanced imaging, offering a valuable resource for exploring the neural coding of natural actions. ▪️ Supports the merging of various data types within both supervised and self-supervised models, producing high-quality latent representations. 𝐊𝐞𝐲 𝐀𝐝𝐯𝐚𝐧𝐜𝐞𝐦𝐞𝐧𝐭𝐬 𝐨𝐟 𝐅𝐫𝐚𝐦𝐞𝐰𝐨𝐫𝐤 – ▪️ It eliminates human bias in behavior classification ▪️ mTPM enables the capture of more intricate neuronal dynamics at the single-neuron level. ▪️ This framework combines behavioral and neural data into a cohesive representational space. 📌 Instead of employing UMAP to separately embed each modality or relying on support vector machines to enforce a fixed mapping between neural activity and behavior, while neglecting their inherent dynamics. We extend our congratulations to the researchers for their significant contributions to the field. It is with great satisfaction that we note our miniature 2-photon microscope has proven to be an effective tool in supporting their research endeavors. Explore our advanced imaging solutions: transvista.com/supernova-ser… #Neuroscience #BehavioralAnalysis #TwoPhotonImaging #mini2P

🚀 Join us at Harvard Med! Discover how miniature multiphoton imaging is enabling neuroscience in freely moving animals. 🧠 Miniature Multiphoton Systems for Neuroscience Workshop 📍 Warren Alpert 236, 220 Longwood Ave 📅 Oct 27 | 12:00–15:00 🗣️ Technical Talks User Experience 🔬 Live Demo of SN-100 System ⚡ Featuring Axon 920 femtosecond laser 🎟️ Scan QR (below) to register — limited seats! Co-hosted by Transcend Vivoscope & Coherent Pizza will be served 🍕🍕🍕🍕🍕. Be on time! #Neuroscience #Multiphoton #Mini2P #BrainImaging #InVivoImaging #HarvardMed #TwoPhoton #NeuroTech

We’re supporting the course with expert guidance and advanced tools like the Bergamo® III, Mini2P, and DIY multiphoton kits built with Thorlabs parts. Attendees will explore imaging techniques including multiphoton microscopy, light-sheet imaging, and optogenetics!

Thorlabs is onsite at Cold Spring Harbor Laboratory (@CSHL) for the “Imaging Structure & Function in the Nervous System” course, which runs through August 12! #CSHLImaging25 #Thorlabs #Neuroscience #Microscopy #BergamoIII #Mini2P #DIYMicroscopy

🚀 #JNS2025 Day 2: See How We're Redefining Imaging in Freely Moving Animals! The excitement continues at #JNS2025! Researchers are lining up to experience our groundbreaking systems that delivers: ✔ Single Dendritic Spine Resolution ✔ Multicolor Imaging ✔ Deep Brain Imaging ✔ Millimiter Field of View Come to meet us at Booth #61 and discover how our technology can enhance your experimental outcomes. Let's explore solutions tailored to your research needs. #Neuroscience #Imaging #Mini2P #InVivo

📌Applications are open for the SuperNOVA-100 Demo Program, offering advanced subcellular-resolution imaging via a miniature two-photon microscope designed for freely moving subjects. To ensure complete submissions, please follow steps as below: ① Prepare: ✔️CV ✔️Experimental design ✔️Technical requirements ✔️Proposed timeline ② Fill application form: bit.ly/SuperNova-100_DEMO_Ap… or send the application directly to us: info@tvscope.cn 🔗Product details: en.tv-scope.com/Products_det… Applications are being reviewed as received. #Neuroscience #TwoPhoton #InVivo #m2PM #MultiPhoton #Imaging #Mini2P #Dendritic #Astrocyte #Glial #Neuron

Advancing Deep-Brain Imaging Technology 🎉We congratulate Prof. Runlong Wu (Peking University & Beijing Information Science & Technology University) for his insightful presentation at the GRC Meeting on "A Versatile Miniature Two-Photon Microscope for Multicolor Deep-Brain Imaging," including meaningful updates on the m2PM development progress. This work presents significant technical advancements in deep-brain imaging, successfully integrating miniaturization with multicolor imaging capabilities. The development of this microscope system demonstrates important progress in overcoming key challenges in neural imaging research. We are honored to have supported this innovative research. And we look forward to seeing how this technology will enable new research directions in neuroscience. #Neuroscience #TwoPhoton #InVivo #m2PM #MultiPhoton #Imaging #Mini2P #Dendritic #Astrocyte #Glial #Neuron #GRC

Neuroscientists: What If You Could Image Single Dendritic Spine in Freely-Moving Animals? We're about to open applications for an exclusive Supernova-100 Demo Program—your chance to test a miniaturized two-photon microscope designed for: ✔ High-resolution neural imaging in freely-moving animals ✔ Ultra-compact & lightweight headpiece design (~2.6 g) ✔ Deep-tissue penetration (800 μm) or GRIN lens for deep brain imaging ✔ Low photobleaching enables continuous imaging (24 hours) ✔ User friendly - true plug and play 📅 Applications open June 2nd – Stay tuned! 🔗 Learn more: lnkd.in/gzDRMHtN 💬 Comment below: What's your biggest challenge with in vivo neural imaging? #Neuroscience #TwoPhoton #InVivo #m2PM #MultiPhoton #Imaging #Mini2P #Dendritic #Astrocyte #Glial #Neuron

Mini2Pならイメージングして、固定してISHまでそのままいけるぜみたいな感じだけど、うまくいくのか？？

🚀 The wait is over. Stop overthinking—pair the compact, fixed-wavelength Axon FL with any brand of miniaturized multiphoton microscope. Resolve calcium signal in tiny processes like axons, dendrites and spines in brains 🧠 of freely moving animals 🐭. Reach out to talk about our laser solution for your multiphoton miniscope and beyond. Great collaborative effort between Coherent, business partners and great customers scientists! Thank you! #microscopy #neuroscience #mini2p #multiphoton #2Photon

In vivo brain imaging made simple. The new AXON FL module turns the Axon 920 TPC into a plug-and-play Mini2P solution—clean pulses, easy integration, flexible setup. More info bit.ly/44tvEOd #LifeSciences #Mini2P #Neuroscience #BrainImaging #UltrafastLasers

I had a great time at the @MPFNeuro Advanced Neurotechniques Course this week, teaching a mini2P module w/ @LinTianPhD, @JRoshgadol & J Kerr! It’s been a while since I’ve stayed up that late analyzing data 😅 So impressed with our amazing students & the beautiful MPFI campus 🤩

We’re excited to partner with the @MPFNeuro to advance brain research through cutting-edge imaging technology! This collaboration brings our Mini2P two-photon microscope and other imaging systems to MPFI, enabling researchers to observe neural activity in remarkable detail.

We are pleased to announce an exciting new technology and research partnership with @Thorlabs that will give our researchers access to groundbreaking new Mini2P imaging. Read more about the Thorlabs Innovation Center at MPFI and how this partnership will allow scientists to see neural activity in unprecedented detail:🔬 buff.ly/mv3DWN8

ThorlabsのMINI2Pがラボにインストールされました！日本ではまだ2台目だそうです。

Excited to get this grant from NFR!!! It opens new chance to attract talents to work with us developing new miniature microscopes #Mini2P for studying exciting questions at @KISNeuro. Many thanks to my colleagues, my mentors and my lab members! Zong lab keeps moving!!

🚀We’re thrilled to introduce the new and improved Mini2P Turnkey Solution featuring Silicon Photomultipliers (SiPM) technology. 🚀 #Mini2P #TwoPhotonMicroscopy #Neuroimaging #CalciumImaging #InVivoImaging #FluorescenceImaging #ResearchTools #behaviour #upgrade #miniscope