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Tick Exposure Patterns and Associated Risk Factors in Northeastern China

Background: In northeastern China, tick-borne diseases pose a major public health challenge, which is exacerbated by environmental and anthropogenic changes. This study was aimed at assessing the...

AF2-mutation: adversarial sequence mutations against AlphaFold2 in protein tertiary structure...

Proteins are essential macromolecules that perform functions according to their conformational dynamics. Studying the conformational changes induced by protein mutations is the standard approach used...

Advances in gasdermin activation, regulation, and targeted drug development

Proteins of the gasdermin family are executors of pyroptosis. Upon cleavage-dependent/independent activation, gasdermins form pores on the cell membrane, which damage the integrity of the cell...

Moracin M derivative targeting PDE4 for the treatment of psoriasis

Phosphodiesterase-4 (PDE4), a member of the phosphodiesterase superfamily, has highly important roles in cyclic nucleotide signaling pathways and a variety of skin disorders. Blocking PDE4 activity...

Performance Comparison of Machine Learning Classifiers and Cardio-Sense Ensemble for Heart Disease...

Objective: Heart disease remains a leading cause of global mortality; consequently, accurate, reliable, and interpretable predictive models are needed for early diagnosis. This study was aimed at...

LLM-Based Multimodal Planning for TAVR: Independent Validation, Calibration, and Efficiency Gains

Small Molecules to Treat Cardiovascular Disease: Cardiac Myosin Inhibitors

Graphene Oxide–based Biomaterials in Sports Medicine

This review summarizes recent advances in the application of graphene oxide (GO) in sports medicine with an emphasis on cartilage repair, skeletal muscle regeneration, ligament and tendon repair, and...

Digestive System Toxicities of Immune Checkpoint Inhibitors: Mechanisms and Clinical Implications

Immune checkpoint inhibitors (ICIs) have achieved remarkable efficacy in treating malignancies but may simultaneously induce immune-related adverse events (irAEs), among which ICI-related digestive...

Albinism-Associated Genes and Non-Skin Cancer: Bioinformatics Analysis of Relevant miRNAs

Enhanced Bayesian Spline Regression Approach for Modelling Trends in Infections Caused by Pathogens...

Background: The Foodborne Diseases Active Surveillance Network (FoodNet) monitors illnesses caused by enteric pathogens at 10 U.S. sites to track progress toward federal disease reduction goals. The...

Potential Roles of the Nasal Microbiome in Pathogen Exposures in Dairy Workers

Objective: Livestock workers are exposed to bioaerosols comprising pathogens including influenza D virus (IDV), influenza A (IAV), and methicillin-resistant Staphylococcus aureus (MRSA), all of which...