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This is an esophagus biopsy with a lymphocyte predominant/lichenoid pattern of injury. Sometimes it correlates with skin lichen planus but more often another type of immunologic alteration is present. This pattern can be accompanied by strictures. Note the squamous apoptosis.

Intestinal elastosis/elastofibromatous change produces a polyp and probably reflects a damaged submucosal blood vessel.

Appendicitis with an incidental serrated epithelial proliferation. The preferred terminology is "serrated polyp" rather than SSL as they have different genetics to their colonic counterparts. NB this is not LAMN as the muscularis mucosae is intact @Pathoutlines @RaulSGonzalezMD

#GIPath #Diagnosethis #Pathresidents 1/2 Look what crossed my my microscope ? The key is in the bitonal hue of this esophagus with sharply demarcated layers ,strong pink superficial ,intraepithelial cleft ,partially detached ,other fragments with just strips of superficial necrotic epithelium . Make the Dx ,then go to the endoscopic appearance bonus . #PathOutPic

Pyloric gland adenoma in uninflamed gastric body. There is an association with autoimmune gastritis (pyloric metaplasia progressing to pyloric adenoma) but this patient does not have it. Note the appearance of the surface of the adenoma versus the adjoining foveolar epithelium.

Rectal muciphages; useful to identify the distal biopsy in an unlabelled colonic series. #Pathologists dont confuse them for sampling of a xanthoma! #GIPath

Help needed with interpretation of this mismatch repair pattern! H&E of an upper GI adenocarcinoma 👇

What’s the most likely history for this case? #PathQuiz #PathX

This example of colorectal malakoplakia presented as a mass lesion. The pale pink appearance of the histiocytes is a clue to search for Michaelis-Gutmann bodies. #umiamipath Reference: Am J Surg Pathol. 2020 Sep;44(9):1251-1258. PMID: 32301754.

Myointimal hyperplasia of mesenteric veins has been known for decades to cause segmental ischemic disease-cured by removing the affected segment. More recently, @RhondaYantiss did a wonderful job describing the findings in mucosal biopsies. #UMiamiPath PMID: 28817406