Tankyrase-1-mediated PARsylation directs TFEB partner switching to regulate selective Wnt target gene expression doi.org/10.1016/j.mocell.202… #PolyADP-Ribosylation #Tankyrase-1 #TCF-1/LEF-1 #TranscriptionFactorEB #Wnt

How about DNA-PolyADP-ribosylation? Authors from the O'Sullivan lab show that TARG1-regulated DNA ADP-ribosylation controls telomere replication. Article here: nature.com/articles/s41594-0… and a nice associated piece here: nature.com/articles/s41594-0…

We have an PhD studentship available in our lab to understand how #polyADP-ribose is involved #dementia and #ALS. Come join us and learn cool methods in #drosophila, #biochemistry and #biology. See here for more details findaphd.com/phds/project/al…

yeah odd circumstances like some polyUb protein about to be destroyed or protein with mad polyADP ribosylation but twitter-level question it is RNA and not at all close

Alcl dysplays sometimes very anarchical cytology, with pseudosyntitia pictures, but I totally agree with you. Furthermore, donut-like cells like here, can be observed in carcinoma mets...very tough case as the presentation is polyadp HSM, no primitive tumor identified so far

2) production of reactive oxygen species deriving from a variety of enzymatic sources, including uncoupled endothelial nitric oxide synthase and the electron transport chain, causes DNA damage and activates the NAD -consuming enzymes polyADP-ribose polymerase 1 (PARP1). This

Well done Song My!!!! very very nice Regulation of ALT-associated homology-directed repair by polyADP-ribosylation pubmed.ncbi.nlm.nih.gov/3304…

Regulation of ALT-associated homology-directed repair by polyADP-ribosylation | Nature Structural & Molecular Biology nature.com/articles/s41594-0…

Regulation of ALT-associated homology-directed repair by polyADP-ribosylation | Nature Structural & Molecular Biology. A very stimulating work from Roddy O’Sullivan, happy to have collaborated! nature.com/articles/s41594-0…

Compliqué car rien de spécifique ni de constant. Forte fièvre surtout si prolongée, tachycardie ( /- au delà de ce qu’on attend avec la température associée), polypnée à auscultation normale, diarrhée/vom/doul abdo, /- signes de Kawa (conjonctivite, cheilite, polyadp cervicale)

Does it happen often that papers are rejected based on arguments that show editor/reviewers did not care to read the work? My favourite rejection comment on a recently sent review was "Can PolyADP-Riboslyaltion be considered a post-translational modification?"🙄#AcademicChatter

SIRT6-PARP1 is involved in #HMGB1 polyADP-ribosylation and acetylation and promotes chemotherapy-induced autophagy in leukemia tandfonline.com/doi/full/10.…

Check out this paper in which Zhang, Cheng et al. developed NAD analogues as labelling probes to detect protein PARylation catalyzed by human polyADP-ribose polymerase 1 (PARP1) and PARP2: 10.1038/s41467-019-12215-4

So they r discussng Christmas & here I am analyzing functionl mechanism of polyADP-ribosepolymerase Ugh sino sapiosexual dyan shoshotain ko!