Senior Editor @NatureSMB. Views and opinions are personal.

Joined May 2012
11 Photos and videos
Dimitris Typas retweeted
Happy to see our work on defining a dependency map of short linear motifs out. We use base editing screens to install more than 80000 mutations into SLiMs in more than 4000 proteins to determine their contribution to cell fitness. nature.com/articles/s41594-0…
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Dimitris Typas retweeted
🔥 Chem(bio) friends, this one is big!! IRB Barcelona is opening a Group Leader position in Chemical Biology! 💜 If your research plan and vision are at the interface of synthetic chemistry, chemical biology, and biomedicine, please check the call! 👉recruitment.irbbarcelona.org…

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A well-worth-your-time Comment by Dr. Edith Heard, of @TheCrick, and Dr. Gitte Neubauer, one of the founders of Cellzome, now at GSK, is out @NatureSMB . They provide valuable insight into what makes a successful partnership between academia and industry. nature.com/articles/s41594-0…

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Tempted to add (more) METAL gifs, but we @NatureSMB are indeed glad to feature METALoci and the conceptual advance imparted by the study in our pages.
21 Nov 2022
How is sex determined? How is it encoded in the #3Dgenome? Happy to share my PhD work. Sex-determining 3D regulatory hubs identified w METALoci, a new genome spatial auto-correlation approach With @jrotwitguez Capel Lab @mamartirenom @Dariloops Thread 👇biorxiv.org/cgi/content/shor…
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Late to the party, but I wanted to highlight a recent @NatureSMB paper by the Hajkova and Vaquerizas labs, which notably advances our understanding of how chromatin organisation regulates gametogenesis. Very enjoyable and insightful work! nature.com/articles/s41594-0…
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Our September @NatureSMB issue is out! nature.com/articles/s41594-0… We feature very interesting papers on ubiquitylation and degradation. Really excited to continue to serve the proteostasis and PTMs communities and publish conceptually insightful work.

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Dimitris Typas retweeted
Great to see our work featured in @NatureSMB! Thanks @DimitrisTypas for your coverage! @LabBoke @DexeusMujer
New online! A snapshot of proteostasis in human oocytes bit.ly/488NJTz
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A captivating read on a very interesting topic, the closer-than-anticipated relationship between ubiquitin and ADP-ribose just out @NatureSMB, nature.com/articles/s41594-0…

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Dimitris Typas retweeted
New online! Q&A with Yael David and Charles Rice on using chromatin biology to understand hepatitis bit.ly/4nYQqwI
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Dimitris Typas retweeted
18 Jul 2025
Proud to share what we hope will be a reference study on human oocyte proteostasis. Young-donor eggs show globally reduced organelle activity vs. somatic cells, with an even steeper drop as they mature. 👇 for @zaffagg3 's detailed explanation embopress.org/doi/full/10.10…

📣 Paper alert!! Excited to share the 2nd research paper from my time in the @LabBoke at @CRGenomica, out today in the @embojournal! We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?" We collaborated with @DexeusMujer and employed #healthy human oocytes freshly donated for heterologous IVF 1/
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On vacation, but so happy this is out and very proud to have had this discussion. I hope that the @NatureSMB readers appreciate it.
Replying to @Yael_David__
And to top it all off, @DimitrisTypas @NatureSMB published today a fantastic Q&A with Charlie @RiceLaboratory @RockefellerUniv, and me discussing our recent Hepatitis B chromatin paper in @CellCellPress! Such an honor to share this space. 🙏🏻 @NobelPrize nature.com/articles/s41594-0…
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Dimitris Typas retweeted
A transcription balance required for genome stability 🧬⚖️ Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on ⁦⁦@NatureSMB#CryoEM #transcription nature.com/articles/s41594-0…

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Scientists travel to work. Some continue to travel during their career, some set roots to an adopted country, some return. @NatureSMB will publish 5 pieces on those that returned. The first discusses Dr. Gomes Dias' return to Brazil. Touching inspiring. nature.com/articles/s41594-0…
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Out @NatureSMB a Review on origin licensing with the most comprehensive (and coolest!) movies on how pre-RC assembly works. Decades of structural and biochemical work are beautifully illustrated. Kudos to @janetiwasa, John Diffley and Bruce Stillman. nature.com/articles/s41594-0…
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On the way to #cshlubiq; the speakers and posters sound top-notch. If you have any questions about @NatureSMB or just want to chat science, please feel free to say hi.
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A bit late to promote this excellent work reporting the development of BRISC molecular glues (BLUEs) nature.com/articles/s41594-0…. This paper is the first in a series of insightful ubiquitylation-related manuscripts with disease-related relevance @NatureSMB will publish
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Dimitris Typas retweeted
Please see our discovery of first-in-class BRISC deubiquitylating enzyme inhibitors rdcu.be/edRwF. A great journey with Elton Zeqiraj, Francesca Chandler, Joe Salvino. High-throughput screens, cryo-EM structure and ontarget activity to reduce inflammatory signals.

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