Ruxolitinib Cream Shows Strong Benefits in Atopic Dermatitis A new updated #metaanalysis of five #randomizedtrials (n=1912) confirms that #ruxolitinib cream significantly improves #atopicdermatitis outcomes compared with vehicle. ✨ Key findings: • Higher rates of #IGA treatment success at 4 and 8 weeks • Significant improvement in #EASI75 and #itch reduction • Consistent benefits across ages and doses • Safety profile comparable to vehicle, with no increased risk of #adverseevents 📌 Takeaway: Ruxolitinib cream is an effective and well‑tolerated #topical option for managing atopic dermatitis. 🔗 doi.org/10.1111/pai.70281 #pai_journal #systematicreview #ruxolitinibcream #AD @MartinCevallosC

🧪 Randomized clinical trials in cardiac surgery: necessary—but exceptionally difficult to perform. 📘 EJCTS ↓ 🔗 academic.oup.com/ejcts/artic… 📝 SECCE ↓ 🔗 secce.es/en/randomized-clini… #CardiacSurgery #RandomizedTrials #ClinicalResearch #EJCTS #SECCE

#RandomizedTrials in individual patients – #Nof1 #RCTs – provide the highest certainty evidence of treatment impact in an individual. The epitome of best clinical practice. This article gives a step by step for setting up and running an N of 1 trial. pubmed.ncbi.nlm.nih.gov/3409…

BIOSTAT2025 in Varazdin, Croatia!🇭🇷 I’m attending the #BIOSTAT2025 conference organized by Hrvatsko Biometrijsko (Croatia Biostatistics), Fakultet Organizacije Informatike (#foi) in Varazdin and the International Biometric Society (#IBS). I’ll be presenting my work on flexible competing risk modeling and chairing a session today! #Biostatistics #SymbolicDataAnalysis #CompetingRiskModel #RandomizedTrials #Croatia #Hrvatsko #Biostat2025 @MUSC_COM @MUSC_CGH @AmstatNews @musc_cgs

🛶 New blog post: "Up the creek without a paddle? We can help navigate the consent river in pragmatic cluster randomized trials" by Cory E. Goldstein, Stephanie N. Dixon, Monica Taljaard and Charles Weijer When designing pragmatic cluster randomized trials, the question of consent often arises. Should patient consent be sought if the clinic is randomized? This blog post addresses the complexities of consent in cluster randomized trials, providing guidance on when this design is justified and how to approach consent waivers responsibly. A flow chart from the authors offers practical support for researchers navigating these challenges #bioethics #clinicaltrials #researchethics #randomizedtrials 💻 Read the full blog post here: blogs.bmj.com/medical-ethics…

🙈 #RandomizedTrials often claim to be #blinded yet are prone to inadequacies in their methods. In this #JGIM #Perspective, #ClinicianScientists @Sunnybrook provide a cautionary framework for interpreting blinding in #EBM buff.ly/3YOV85O

#medtwitter #neotwitter #rct #randomizedtrials #evidencebasedmedicine

#CochraneDaily On Banana Day, there are more than 100 reports of trials of banana products in @CochraneLibrary CENTRAL #NationalBananaDay daysoftheyear.com/days/banan… #RandomizedTrials

The elusive forest plot is demystified in the #BJJ Online Research Methods & Paper Review Course! Book now for June or November! #ResearchMethods #MetaAnalysis #RandomizedTrials #Orthopedics ow.ly/1Z3p50QyI5J

Packed room for wine & cheese session with @_MiguelHernan at #IWHOD2023 in Athens. For drug repurposing, decisions to graduate compounds to #randomizedtrials have been based on preclinical data. How do we incorporate clinical (#observational) data to this process? Should we?

The European Organisation for Research and Treatment of Cancer (@EORTC) endorses #TargetTrial emulation with #RWD. An organization with unmatched expertise in the design of #randomizedtrials embraces their explicit emulation when using observational data. ejcancer.com/article/S0959-8…

The deadline for submissions to the upcoming Special Issue on Integration of Observational Studies with Randomized Trials is extended until JUNE 15, 2022. For more information, please visit our website: degruyter.com/journal/key/jc… #causalinference #randomizedtrials

NEW: A #TargetTrial emulation to study the comparative effectiveness & safety of fertility treatments, led by @Jennifer_Yland. Another example of how #observational databases can be used to extend the results from (necessarily small) #randomizedtrials for better decision making.

An early #guideline on #COVID before the #randomizedtrials came in shows how a rapidly produced guideline when evidence is limited can provide direction – and primarily ensure caution against indiscriminate use of unproven therapies. bit.ly/3zYiXd7

We invite you to submit papers for the upcoming Special Issue on Integration of Observational Studies with Randomized Trials in the JOURNAL OF CAUSAL INFERENCE. Deadline: Dec 15, 2021 See the full call for papers at: degruyter.com/publication/jo… #causalinference #randomizedtrials

Hope you can sleep well at night, because these News about Mass #NeoFascist⚠️ #Experiments💉 #RandomizedTrials🏥 on both Healthy People and those Affected by #Immunodeficiency🚨 Give me Headaches & Nightmares about our not so distant #DystopianFuture⚠️ STOP #VaccinePassports 🛑

@DrCathyCraven is presenting to our Division about The trials and tribulations of #spinalcordinjury clinical trials #clinialtrials #rehabilitation #physiatry #randomizedtrials #PatientsasPartners #patientsincluded

How to design #largescale #randomizedtrials on #studentachievement? 📢Excited to announce our newly published paper compiling #multilevel design parameters w/ Oliver Lüdtke, @ArteltCordula, & Martin Brunner in #JREE tandfonline.com/doi/full/10.… #educationaleffectiveness #poweranalysis

Yet another beautiful theory slayed by ugly facts. And therein lies the essence of scientific enquiry. Reiterates why we need robust #randomizedtrials to guide management decisions. #COVID_19 @credoworkshop @ACORDISM @spkalantri @AnantBhan @epigiri @GKangInd

5/ Also, so much talk about extending results from #randomizedtrials to a target population. But so little guidance on how to design data collection. Here we provide a unified description of study designs for #transportability and #generalizability. pubmed.ncbi.nlm.nih.gov/3332…