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So excited to publish on PCa CTCs in @NatRevUrol! Thanks to the whole team including my supervisors @LambAlastair @wandering_gu @ProfClaireEd @ian263 @JJDGroupOxford #LiquidBiopsy #CTCs #ProstateCancer #SPACE_Study Free, full-text access here: rdcu.be/eZmBg
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@GortzMagdalena summarises neatly the possibility of Imaging replacing prostate biopsy in diagnosing #PCa "What is 'significant' #ProstateCancer? In my opinion we do not know!" So....how long until we do know?! ...and what do we need to know? #SPACE_Study #CuttingEdgeResearch
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Copy that (what Matt said, and also your follow up comment Tyler) but I would go a step further. •MRI is an indicator of unfavourable histology •Histology is an indicator of unfavourable molecular (i.e. potentially lethal somatic & TME) profile #WatchThisSpace #SPACE_Study
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Enjoyed writing this editorial/response to #BARCODE1 in @NEJM last month Great job @KotechaPinky, @Sandy_Figiel, Prabs Rajan. THM: •Screening don't work #ProstateCancer (yet!) •Including genetic testing makes sense •Somatic may be more relevant than germline... #SPACE_Study
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The introduction of a genetic risk component to prostate cancer screening is a welcome addition to prostate specific antigen testing and MRI, write @LambAlastair and colleagues bmj.com/content/389/bmj.r103…
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Exciting role for data scientists & bioinformaticians! If you're into #DeepLearning & #SpatialBiology and want to transform #ProstateCancer diagnosis, apply now to join @QMBCI! Deadline: 20 May. #SPACE_Study #Organscale
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•Are you a data scientist / bioinformatician? •Interested in #DeepLearning applied to #SpatialBiology? •Do you want to transform #ProstateCancer clinical decision-making? Based @QMBCI Apply here!! 👇 (closing date 20th May) qmul-jobs.tal.net/vx/candida… #SPACE_Study #Organscale
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Nice summary of Artificial Intelligence >> Machine Learning >> Deep Learning from @michael_gorin to kick off @BJUIjournal session at #AUA25 Will image segmentation CNNs provide answer to IDing "potentially lethal" prostate cancer (on MRI or histology)? I think so! #SPACE_Study
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Great to see at #EAUlab #EAU25 - the role of TME and tumour heterogeneity generating interesting discussions on the future role of #omics #3Dimaging Excited to be joining the team #SPACE_Study
Excellent talk from @Sandy_Figiel in @Uroweb #EAUlab session at #EAU25 presenting our cool data (I'm bias!) on #SpatialTranscriptomics & #ClonalAnalysis to detect unique features of metastasing clones in #ProstateCancer. @OxPCaBiol #SPACE_Study #3DLightsheet
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Excellent talk from @Sandy_Figiel in @Uroweb #EAUlab session at #EAU25 presenting our cool data (I'm bias!) on #SpatialTranscriptomics & #ClonalAnalysis to detect unique features of metastasing clones in #ProstateCancer. @OxPCaBiol #SPACE_Study #3DLightsheet
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•Are you a data scientist / bioinformatician / computational biologist? •Are you interested in #SpatialGenomics? •Do you want to apply your skills to big questions in #ProstateCancer? Apply here!! 👇 (closing date 12th Feb) qmul-jobs.tal.net/vx/mobile-… #SPACE_Study #Organscale
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Delighted to finally share our exploratory article showing utility of RNA-based phylogenetics compared to DNA approaches as benchmark journals.plos.org/plosone/ar… Originally intended as companion piece to nature.com/articles/s41586-0… #SPACE_Study #SpatialProstate youtu.be/YdzF0-PFXhc
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V cool to be starting first proper day @QMBCI Charterhouse Sq! Thanks to @fcicca & Nitzan Rosenfeld for taking me on as Group Leader in Centre for Cancer Evolution🧬. And to @GuysUrology for making it work🙏 Looking forward to rebuilding #SPACE_Study team here - recruiting soon!
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Huge congrats 👏 to @SophiaAbusamra on winning Yr2 DPhil student present 1st prize 🏆🏅 @ndorms @BotnarOxford symposium Really excited to c where we get to w #CTCs as #LiquidBiopsy for potentially lethal #ProstateCancer #SPACE_Study @OxPCaBiol @BioRad #CelSelect @BioRadFlowAbs
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Super chuffed that our #SPACE_Study group won #TeamOfTheYear award 🏆🥳🏅 at #NDSAwayDay2024!! Been a gr8 yr or two for #spatialbiology in #ProstateCancer-really pleased that our team got this recognition! Thanks @NDSurgicalSci👏 youtu.be/YdzF0-PFXhc?si=QUfS… molecular-cancer.biomedcentr…
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Pleasure to present our #SPACE_Study work using #SpatialTranscriptomics to unpack tumour heterogeneity in #ProstateCancer, alongside @Sandy_Figiel & @thineskrishna The BIG Qs: -Who to investigate? -Who to treat? -How to keep treating? These approaches have the answer!! #AUA24
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Thanks to @AmerUrological #AUA24 for oppo to present 3 consec talks on ##SPACE_Study work @OxPCaBiol Great discussions in the room. Thanks for the probing questions. Love that #AUA still prioritise basic science - a whole session on #SpatialBiology and #TME in #ProstateCancer!!
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@Freddie_Hamdy points out #AchillesHeel: we still don't understand biology of #PCa heterogeneity & lethality We can't start screening as •we don't know what to look for •we don't know whether to treat! Cautions against giving men a #ProstateCancerPassport #EAU24 #SPACE_Study
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Super chuffed re clean sweep of poster prizes for #SPACE_Study/@OxPCaBiol members w both @Wien_Yin (1st) & @SophiaAbusamra (2nd) winning at #OxSymp24 @OxfordCancer! Well done team 👏 🏆🍾 Onwards w #SpatialProstateBiology & #LethalClone analyses @NDSurgicalSci #OrganscaleNodes
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Are you interested in CTCs? And the potential they offer to unpack clonal heterogeneity & mechanisms of metastasis in #ProstateCancer? Come see @SophiaAbusamra's poster @OxfordCancer #OxSymp24 #LethalClone #Space_Study @QuantumBiobank @NDSurgicalSci @ndorms
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Please come see our poster showing how we use #SpatialTranscriptomics to deduce clonal metastatic relationships in high-risk surgically treated #prostatecancer #LethalClone #Space_Study @QuantumBiobank @Wien_Yin & @Sandy_Figiel will answer all your qus! @OxfordCancer #OxSymp24
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