So excited to publish on PCa CTCs in @NatRevUrol! Thanks to the whole team including my supervisors @LambAlastair @wandering_gu @ProfClaireEd @ian263 @JJDGroupOxford
#LiquidBiopsy #CTCs #ProstateCancer #SPACE_Study
Free, full-text access here: rdcu.be/eZmBg
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29 Oct 2025
@GortzMagdalena summarises neatly the possibility of Imaging replacing prostate biopsy in diagnosing #PCa
"What is 'significant' #ProstateCancer? In my opinion we do not know!"
So....how long until we do know?!
...and what do we need to know?
#SPACE_Study
#CuttingEdgeResearch
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21 Jul 2025
Copy that (what Matt said, and also your follow up comment Tyler) but I would go a step further.
•MRI is an indicator of unfavourable histology
•Histology is an indicator of unfavourable molecular (i.e. potentially lethal somatic & TME) profile
#WatchThisSpace #SPACE_Study
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28 May 2025
Enjoyed writing this editorial/response to #BARCODE1 in @NEJM last month
Great job @KotechaPinky, @Sandy_Figiel, Prabs Rajan.
THM:
•Screening don't work #ProstateCancer (yet!)
•Including genetic testing makes sense
•Somatic may be more relevant than germline...
#SPACE_Study
28 May 2025
The introduction of a genetic risk component to prostate cancer screening is a welcome addition to prostate specific antigen testing and MRI, write @LambAlastair and colleagues
bmj.com/content/389/bmj.r103…
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7 May 2025
Exciting role for data scientists & bioinformaticians! If you're into #DeepLearning & #SpatialBiology and want to transform #ProstateCancer diagnosis, apply now to join @QMBCI! Deadline: 20 May. #SPACE_Study #Organscale
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7 May 2025
•Are you a data scientist / bioinformatician?
•Interested in #DeepLearning applied to #SpatialBiology?
•Do you want to transform #ProstateCancer clinical decision-making?
Based @QMBCI
Apply here!! 👇 (closing date 20th May)
qmul-jobs.tal.net/vx/candida…
#SPACE_Study #Organscale
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27 Apr 2025
Nice summary of Artificial Intelligence >> Machine Learning >> Deep Learning from @michael_gorin
to kick off @BJUIjournal session at #AUA25
Will image segmentation CNNs provide answer to IDing "potentially lethal" prostate cancer (on MRI or histology)? I think so!
#SPACE_Study
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23 Mar 2025
Great to see at #EAUlab #EAU25 - the role of TME and tumour heterogeneity generating interesting discussions on the future role of #omics #3Dimaging
Excited to be joining the team #SPACE_Study
23 Mar 2025
Excellent talk from @Sandy_Figiel in @Uroweb #EAUlab session at #EAU25 presenting our cool data (I'm bias!) on #SpatialTranscriptomics & #ClonalAnalysis to detect unique features of metastasing clones in #ProstateCancer.
@OxPCaBiol #SPACE_Study #3DLightsheet
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23 Mar 2025
Excellent talk from @Sandy_Figiel in @Uroweb #EAUlab session at #EAU25 presenting our cool data (I'm bias!) on #SpatialTranscriptomics & #ClonalAnalysis to detect unique features of metastasing clones in #ProstateCancer.
@OxPCaBiol #SPACE_Study #3DLightsheet
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29 Jan 2025
•Are you a data scientist / bioinformatician / computational biologist?
•Are you interested in #SpatialGenomics?
•Do you want to apply your skills to big questions in #ProstateCancer?
Apply here!! 👇 (closing date 12th Feb)
qmul-jobs.tal.net/vx/mobile-…
#SPACE_Study #Organscale
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7 Jan 2025
Delighted to finally share our exploratory article showing utility of RNA-based phylogenetics compared to DNA approaches as benchmark journals.plos.org/plosone/ar…
Originally intended as companion piece to nature.com/articles/s41586-0…
#SPACE_Study #SpatialProstate
youtu.be/YdzF0-PFXhc
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6 Jan 2025
V cool to be starting first proper day @QMBCI Charterhouse Sq! Thanks to @fcicca & Nitzan Rosenfeld for taking me on as Group Leader in Centre for Cancer Evolution🧬. And to @GuysUrology for making it work🙏
Looking forward to rebuilding #SPACE_Study team here - recruiting soon!
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6 Jun 2024
Huge congrats 👏 to @SophiaAbusamra on winning Yr2 DPhil student present 1st prize 🏆🏅 @ndorms @BotnarOxford symposium
Really excited to c where we get to w #CTCs as #LiquidBiopsy for potentially lethal #ProstateCancer
#SPACE_Study @OxPCaBiol
@BioRad #CelSelect @BioRadFlowAbs
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10 May 2024
Super chuffed that our #SPACE_Study group won #TeamOfTheYear award 🏆🥳🏅 at #NDSAwayDay2024!!
Been a gr8 yr or two for #spatialbiology in #ProstateCancer-really pleased that our team got this recognition! Thanks @NDSurgicalSci👏
youtu.be/YdzF0-PFXhc?si=QUfS…
molecular-cancer.biomedcentr…
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3 May 2024
Pleasure to present our #SPACE_Study work using #SpatialTranscriptomics to unpack tumour heterogeneity in #ProstateCancer, alongside @Sandy_Figiel & @thineskrishna
The BIG Qs:
-Who to investigate?
-Who to treat?
-How to keep treating?
These approaches have the answer!!
#AUA24
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3 May 2024
Thanks to @AmerUrological #AUA24 for oppo to present 3 consec talks on ##SPACE_Study work @OxPCaBiol
Great discussions in the room. Thanks for the probing questions.
Love that #AUA still prioritise basic science - a whole session on #SpatialBiology and #TME in #ProstateCancer!!
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6 Apr 2024
@Freddie_Hamdy points out #AchillesHeel: we still don't understand biology of #PCa heterogeneity & lethality
We can't start screening as
•we don't know what to look for
•we don't know whether to treat!
Cautions against giving men a #ProstateCancerPassport
#EAU24 #SPACE_Study
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15 Mar 2024
Super chuffed re clean sweep of poster prizes for #SPACE_Study/@OxPCaBiol members w both @Wien_Yin (1st) & @SophiaAbusamra (2nd) winning at #OxSymp24 @OxfordCancer!
Well done team 👏 🏆🍾
Onwards w #SpatialProstateBiology & #LethalClone analyses
@NDSurgicalSci #OrganscaleNodes
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13 Mar 2024
Are you interested in CTCs?
And the potential they offer to unpack clonal heterogeneity & mechanisms of metastasis in #ProstateCancer?
Come see @SophiaAbusamra's poster @OxfordCancer #OxSymp24
#LethalClone #Space_Study
@QuantumBiobank @NDSurgicalSci @ndorms
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13 Mar 2024
Please come see our poster showing how we use #SpatialTranscriptomics to deduce clonal metastatic relationships in high-risk surgically treated #prostatecancer
#LethalClone #Space_Study
@QuantumBiobank
@Wien_Yin & @Sandy_Figiel will answer all your qus!
@OxfordCancer #OxSymp24
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