🚨 Masterclass on management of colorectal neuroendocrine tumors (well-differentiated) by Dr Jen Chan at #GI25 🌎 rising incidence, primarily driven by rectal NETs 📌 most CR NETs are non functional ‼️Grade, size and depth of invasion are some high risk features pre-resection. 💡 EUS important for staging rectal NETs. 📌 Localized rectal NETs: -rectal NET/s <10 mm- endoscopic resection -10-20 mm: Multi-D discussion ->20 mm or LN rectal NETs- LAR or APR -R1 resections are common, consider repeat EUS and multi-D discussion for residual disease management. 📌 Advanced colorectal NETs: -multi-D eval key! -If SSTR , start with SSA (a good test of biology) -following progression- RLT, mTOR inh, TKIs. CAPTEM for G3 -can consider upfront RLT in Ki67 10-55% in select patients based on NETTER-2 #NETsatGI25 @ASCO