#LongNonCodingRNA Liver Fibrosis
LncRNA TILAM
👉Enriched in Activated Hepatic Stellate Cell
👉Located near COL1A1
👉TGFβ-inducible
👉Physically binds to PML➡️maintains PML protein & TGFβ signaling
TILAM LNA or KO➡️⏬Fibrosis in Liver organoid
TILAM KO ➡️⏬ Fibrosis in🐭 choline-deficient, L-amino acid-defined, high-fat diet or CCl4
Alan Mullen lab @HEP_Journal 2023
journals.lww.com/hep/fulltex…
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9 Dec 2025
Mysterious Long Noncoding RNA Found to Play Vital Role in Immunity and Cancer Defense
thailandmedical.news/news/my…
#LongNoncodingRNA #lncRNA #RNA #genes #research #News #Cancer #Immunity #Health
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5 Dec 2025
Virus Long Noncoding RNAs Found to Mimic Human RNAs and Hijack Cellular Functions
thailandmedical.news/news/vi…
#Virus #ViralRNA #LongNonCodingRNA #HumanRNA #Health #News #research #SARSCoV2 #America #UnitedStates #California #Boston #Texas #NewYork #Ohio #London #Europe #Thailand
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300
29 Oct 2025
The LINC01612-DVL2-WNT regulatory axis promotes human endoderm differentiation – a key modulator of human definitive endoderm differentiation. #longnoncodingRNA #DVL2 #WNT #endoderm ow.ly/irxV50XhLBc
@ISSCR @CellPressNews @GairdnerAwards @SickKidsNews
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6 Sep 2025
The emerging roles of long non-coding RNAs in the nervous system. #LongNonCodingRNA #NervousSystem #Genomics #NatureReviewsNeuroscience
nature.com/articles/s41583-0…
45
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11,800
1 Sep 2025
Long Noncoding RNAs Linked to COVID-19 Severity and Diagnosis
thailandmedical.news/news/lo…
#COVID19 #News #SARSCoV2 #Health #Diagnosis #Research #LongNonCodingRNA
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Could #NoncodingRNA shape more than moths and butterflies? New research links it to #evolution and #speciation—raising questions about its role in #HumanCognition and beyond. A PNAS Inner Workings: ow.ly/MVt350Wvn30
#microRNA #LongNoncodingRNA #NewVoices @NewVoicesNASEM
ALT Recent research suggests that the famous case study of peppered moth evolution has a new twist: their intriguing coloration changes are driven by RNA molecules that don’t code for proteins. Just how common such cases are remains the subject of debate. Image credit: Shutterstock/IanRedding.
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#NoncodingRNA plays a crucial role in #butterfly #speciation and #evolution. But what about other #flora and #fauna—or even the #evolution of human #cognition? A PNAS Inner Workings: ow.ly/QSi150Wro5U
#microRNA #LongNoncodingRNA #PepperedMoth #MonkeyFlower
ALT Two pink flowers grow in a patch of grass. Only in recent years have researchers discovered that noncoding RNAs have a significant role in the evolution of the oft-studied plant model system, monkeyflowers. Image credit: Science Source/Stuart Wilson.
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#NoncodingRNA plays a crucial role in #butterfly #speciation—but what about other #flora and #fauna? A PNAS Inner Workings: ow.ly/2f6r50WoqhO
#microRNA #LongNoncodingRNA #evolution #PepperedMoth #MonkeyFlower
ALT Four peppered moths on a rock. Recent research suggests that the famous case study of peppered moth evolution has a new twist: their intriguing coloration changes are driven by RNA molecules that don’t code for proteins. How common these cases are is still up for debate. Image credit: Shutterstock/IanRedding.
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#LongNoncodingRNA #SmoothMuscleCell #Seneascence #Atherosclerosis
LncRNA JPX (just proximal to XIST), in complex with #BRD4 NF-κB, acts as a ROS-Cytosolic #mtDNA-STING downstream to transcriptionally activate #SASP genes (IL-1β/-6/-8 MCP1 TNFα) in senescent SMCs
SMC Jpx KO protects against Apoe-/-🐭#Atherosclerosis ⏬lesional SMC senescence SASP
No sex-specific effects
@atvbahajournals 2024
ahajournals.org/doi/10.1161/…
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3,490
#LongNonCodingRNA #Senescence #Atherosclerosis
JPX, a chromosome-associated regulatory RNA, complexes with BRD4 & p65 (NFκB subunit) to mediates 3D chromatin remodeling &⏫transcriptional activation of senescence secretome genes (CCL2/IL-1β/-6/-8/TNFα) in #SmoothMuscleCell
A prosenescent cascade by HRasV12-#OxidativeStress-mtDNA leak-activated cGAS-STING signaling
SMC JPX KO or JPX gapmeRs i.v. ->⏬🐭atherogenesis & lesional cell senescence SASP
@atvbahajournals 2024
ahajournals.org/doi/10.1161/…
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2,724
#LongNonCodingRNA #LncRNA transcriptomics Lower-extremity #PeripheralArteryDisease -/ T2D #Diabetes
Iliac artery n=79
T2D->⏬ACTA2-AS1
#SmoothMuscleCell microdissected from FFPE section
T2D->⏫LINC00910/RUFY1-AS1/MZF1-AS1 ⏬HIF1A-AS3/XIST!/NEAT1/MIR222HG/MIR28B2CHG
More under-annotated LncRNAs to explore!😄
@JaroslavPelisek @SciReports 2024
nature.com/articles/s41598-0…
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6 Jun 2024
Sun et al. delineated role of #lncRNA #PVT1 in enhancing cell proliferation, colony formation, cell migration & invasion & EMT in #colorectalcancer. PVT1 sponges miR-3619-5p & increases TRIM29 levels.
doi.org/10.1002/cnr2.2085
#CancerReports #Wiley #OpenAccess #LongNonCodingRNA
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#LongNonCodingRNA #SmoothMuscleCell
LncDACH1⏬SMC proliferation migration & #Neointima of #ArterioVenousFistula, partially via ⏬HSP90 abundance & sequestrating SRPK1 in the nuclei in an HSP90-dependent manner
LncDACH1 physically binds to SRPK1 (RNA-IP assay)
LncDACH1 is transcriptionally activated by KLF9
A similar pro-intimal role in #Atherosclerosis?
Writing reads a bit confusing; just interpret the data by yourself 😆
@NatureComms 2024
nature.com/articles/s41467-0…
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1,721
20 Mar 2024
Pleasure to speak at the #APSA 2024 Spring Research Seminar on our lab’s project on linc00152 #longnoncodingRNA in glioblastoma and share some insight into the #TURBOID proximal proteomics approach we’re utilizing to find RNA-protein interactions @A_P_S_A @UABSOM_APSA
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29 Feb 2024
#ArticlesInPress: Unlocking the Dark Matter: Noncoding RNAs and RNA Modifications in Cardiac Aging
Jiayi Kang, James Rhee, Chunyan Wang, Yolander Yang, Guoping Li, and Haobo Li
ow.ly/6xCk50QJjRG
@lihaobo @MassGeneralNews
#NoncodingRNA #Aging #MicroRNA #LongnoncodingRNA
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Enhancer-associated #LongNonCodingRNA #Atherosclerosis
PSMB8-AS1⏫promixal gene transcription of PSMB9 in #EndothelialCell->
Zeb1->
VCAM1/ICAM1->
#VascularInflammation #Atherosclerosis
Serum lipids also regulated by PSMB8-AS1
@CircRes 2023
ahajournals.org/doi/10.1161/…
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Epigenetic Regulation of #Angiogenesis in #PeripheralArteryDisease
A nice review on #LongNonCodingRNA in #EndothelialCell #MuralCell
👤🐭#LimbIschemia
MALAT1
MEG3
SNHG12
ANRIL
LEENE
SENCR
HIF1A-AS1/2...
@NMalhi92 @ZhenBoumanChen #DeBakeyCVJournal 2023
journal.houstonmethodist.org…
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15 Nov 2023
☕️NEW: Takakuwa, Yamazaki et al. show that the #LongnoncodingRNA #NEAT1 domains specify a set of proteins that localize to the outer shell and distinguish #nuclearspeckles from #paraspeckles to preserve their structural identity.
rdcu.be/dq96p
nature.com/articles/s41556-0…
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3,997
23 Aug 2023
“Our goal is to study the role of #longnoncodingRNA, a novel class of #geneexpression regulators, on #exosome #biogenesis, thereby advancing our understanding of these mechanisms and providing the basis for the use of exosomes as novel...” @ColumbiaUDental exosome-rna.com/columbia-res…
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