•The Breakdown: Recent multi-omics and gene expression profiling (such as NanoString analyses) of ME/CFS and Long COVID cohorts have revealed a severe downregulation in antigen presentation pathways. [1, 2]

Online now: Protocol for spatial profiling of immune cells in the mouse cornea and conjunctiva using NanoString GeoMx DSP and nCounterPro platforms dlvr.it/TT15fb #protocol #starprotocols #cellpress

Reason I was asking is because some techs like Visium (10x) and CosMx (Nanostring) give you single cell resolution and spatial information. But hard/impossible to scale to hundreds/thousands of slides a day.

Poking a nanostring: Scientists uncover energy cascades in tiny resonators lifeboat.com/blog/2026/03/po…

10x Genomics generally has better strategic planning than Nanostring. But one area they fell behind is having a library of antibodies for their single cell and spatial applications genomeweb.com/business-news/…

🔬🟣 @GEICAM is already at #ASCO2026, where these days have already been filled with many valuable and inspiring meetings, and day one has kicked off with two oral presentations from international collaborative research featuring authors from our group 👇 🔹NATALEE trial This new analysis from the #NATALEE trial evaluated the prognostic and predictive value of baseline gene expression in stage II/III HR /HER2- early #breastcancer treated with adjuvant ribociclib plus a nonsteroidal aromatase inhibitor versus aromatase inhibitor alone 🧬 Following the previously reported invasive disease-free survival benefit with #ribociclib, this subanalysis included more than 3,000 tumor samples assessed with the NanoString BC360 panel, including #PAM50 molecular subtyping 💊 Ribociclib showed consistent benefit across all molecular subtypes, while greater benefit was observed in patients with higher genomic risk or proliferation, suggesting a potential role for gene expression profiling in future patient selection. 🔹lidERA BC clinical trial This phase III study compared #giredestrantwith standard endocrine therapy in pre- and postmenopausal women with stage I–III ER /HER2- early breast #cancer previously treated with surgery and #chemotherapy when indicated 🧫 In 4,170 patients, giredestrant improved invasive disease-free survival across both menopausal groups and reduced the risk of #metastatic disease 📊 It also showed a comparable safety profile with fewer treatment discontinuations due to toxicity, particularly musculoskeletal pain, supporting its potential as an effective and better-tolerated alternative. 🙌 We are especially proud of the entire team who travelled to Boston, and particularly of Dr. Miguel Martín, founder of GEICAM and its President for 30 years until last year, whose contribution as an author to both studies reflects the long-standing commitment and dedication of our investigators to advancing #GEICAM #BreastCancerResearch #ASCO26. 🙌🚀 @ASCO @ASCOPost @oncofir

I used to be a vocal skeptic of Hans and a key GEP fan, some say as an OG for GEP. I used to lament Hans IHC as the only tool available for my patients, when many trials used GEP instead. But I have been surprised by learning how IHC has dramatically improved over the last decade or so with availability of standardized antibody clones, use of auto strainers, and interpretation consistency. How was I convinced? We did a systematic meta-analysis of >2200 patients from 19 studies. We used the PRISMA diagnostic test accuracy framework for comparing Hans to GEP. library.ehaweb.org/eha/2026/… Remarkably, this analysis now clearly shows that Hans is consistently non-inferior to GEP across current modern studies at a 10% NI margin for Accuracy, Precision, and Specificity. This solid performance of Hans IHC is very much in line with current CAP benchmarks for diagnostic tests, and within the margins of NanoString GEP using FFPE vs original frozen GEP as the original elusive gold standard. Long live Hans as the best currently available SOC for COO across the globe.

On the predictability of progression-free survival in ovarian cancer from NanoString gene expression data biorxiv.org/content/10.64898… #biorxiv_cancer

Super cool! I've done very little nanostring analysis but the long reads are always fun to work with. Are you expecting the same signatures in the old and young cohorts or different signatures for each age cohort?

This particular project was all Nanostring RNAseq. Another team handled it before I got the data. Bulk transcriptomics stuff. There’s a chance we try and do some single cell sequencing on the tissues if a reviewer wants to see that!

Fantástica conferencia de @drpabloortiz en la @FundacionAreces sobre hacia donde va la #Dermatología ✔️Inteligencia Artificial ✔️Ayudas al diagnóstico: confocal, nanostring, telederma... ✔️Medicina personalizada. ✔️Nuevos tratamientos ➡️Mejor atención 🔝🔝👏👏 @dermah12o

Fair to say that ​the physics of this nanostring cascade bears a striking resemblance to the Sitar, a 13th-century Indian instrument? ​ Sitars use Sympathetic Strings (Tarab). When we pluck the main string, the energy cascades into the underlying strings w/o them being touched. ​In the TU Delft experiment, they call it nonlinear modal coupling.

This is fascinating. Scientists have discovered energy cascades inside a nanoscopic vibrating string. Researchers at TU Delft built a nanostring resonator, a mechanical string fabricated on a microchip that is roughly 100× thinner than a human hair. When they vibrated the string at just the first vibrational mode, something unusual happened. Instead of the energy staying in one vibration, it transferred into higher vibration modes inside the same string. The energy moved step by step through: Mode 1 → Mode 2 → Mode 3 → Mode 4 → Mode 5 Scientists only drove the first mode, but the energy cascaded into five coupled vibration modes through a chain reaction called nonlinear modal coupling. This cascade was made possible using a design method called soft clamping, which reduces energy loss and strengthens interactions between vibration modes. why this matters Nanostring resonators are used in extremely sensitive measurement devices. Understanding how energy moves between modes could help engineers build: > ultra-sensitive force and mass sensors > precision frequency control systems > advanced nanoelectromechanical devices (NEMS) In simple terms, scientists discovered a way for mechanical energy to flow across multiple vibration states inside a microscopic system.

Lucia Sobrin, MD, MPH, introduced new nanostring and metagenomic next-generation sequencing technologies that can address the limitations of traditional culture and PCR infectious workups. #ARDS2026 #retina #uveitis

12/40 (continued) Chris Mason, NanoString, Cory Mason, Kathy Surace-Smith, Brad Smith, George Church. (Note: Epstein and Church, Cornell, Gates, Fauci, Rockefeller, Rotary…)

12/40 Biotech nexus: Chris Mason (Cornell geneticist, NASA/Mars expert) tied to NanoString (advisory board, research). Brother Cory: Racine mayor. Brad Smith's wife Kathy led HR/legal at NanoString. From space DNA to COVID tests—Racine's in the gene game.

Tell everyone more about Mason Lab & directed evolution. Colossal Biosciences. Tempus. WorldQuant. Lumina. Nanostring. Cornell. COVID. Rotary. X-Prize. BioAstra. Do you know who George Church is? Epstein does. What about Brad Smith? Bill Gates does? All roads lead to… RACINE.