🔎 Model 1 – Predicting CR/CRi in R/R B-ALL (SOHO 2025, UCL) 🔎
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📊 Key Predictors (Logistic Regression Analysis)
•Philadelphia chromosome
•Ph → OR 6.0 (1.4–26.3) ✅
•Prior lines of therapy
•≤3 → OR 3.8 (1.2–12.1) ✅
•Refractory to last line
•No → OR 2.9 (1.1–8.0)
•Extramedullary disease (LD)
•Absent → OR 2.8 (1.0–7.8)
•BM blasts at LD
•<5% → OR 3.2 (0.9–11.6) ✅
•Higher blast burden = worse odds
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💡 Interpretation
✅ Best chance of achieving CR/CRi:
•Ph disease
•≤3 prior therapies
•Not refractory to last treatment
•No EMD
•BM blasts <5%
⚠️ Lower chance: heavily pretreated, refractory, Ph–, EMD present, or high BM blasts.
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#BALL #CAR_T #PredictiveModel #Response #SOHO25 #HemeOnc
Dr. Chokri Ben Lamine – KSA SOHO Ambassador