Immuno-oncology @Sanofi | Previously @BBS_Harvard @PittetLab @MGHCSB

Joined March 2018
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Excited to share my PhD work in the @PittetLab, published today in @CellCellPress! We show that immunotherapy can expand a distinct interferon-responsive neutrophil state that contributes to successful responses to therapy: sciencedirect.com/science/ar…
❔What is special about an immune system that successfully attacks tumors, compared to one that doesn’t? Our new study in @CellCellPress led by @jgungabeesoon, @Nich and @Mate_Kiss_ aimed to address this question. A joint work with the great @KleinLabHMS authors.elsevier.com/a/1gqie…
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Jeremy Gungabeesoon retweeted
📢 Research Alert! 🧬🔬 🩺 We are super excited that our latest study, led by the great @RubenBill5 & Asa Wirapati, is out: science.org/doi/full/10.1126… We set out to shed some light on the tumor microenvironment and its impact on cancer progression. 🧵

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SPOTLIGHT: @BBS_Harvard @PittetLab @jgungabeesoon demonstrated that neutrophils exhibit remarkable plasticity and could acquire an antitumor phenotype in response to immunotherapy. bit.ly/3KU2Nsb
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Jeremy Gungabeesoon retweeted
The findings suggest that researchers may be able to manipulate neutrophils to make cancer therapies more effective hms.harvard.edu/news/how-low…
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Read more about my PhD work here! @PittetLab @KleinLabHMS
Neutrophils — the most common cell type in the immune system — play a key role in immunotherapy success hvrd.me/vv3X50Nw2xn
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Jeremy Gungabeesoon retweeted
The Garris Lab @MGHCSB @MGH_RI @harvardmed is looking for curious and driven postdoctoral fellows who want to investigate the biology of #dendriticcells in cancer growth and therapy. Interested candidates should send their CV and cover letter to positions@garrislab.com
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Jeremy Gungabeesoon retweeted
The intrepid Mauro (now @DiPilatoLab) and team did it again: CXCR6 enables CTL to control tumors by guiding their interactions with CCR7 cDC in perivascular survival niches of the tumor stroma. Thanks to our fantastic collaborators. See 🧵 for details. cell.com/cell/fulltext/S0092…
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Jeremy Gungabeesoon retweeted
Immune networks within the glial cell ecosystem maintain brain health. Our latest is out today in @nature. Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease. This was a wonderful collaboration with @RudyTanzi and his team. 1/ nature.com/articles/s41586-0…

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Jeremy Gungabeesoon retweeted
Are brain borders the new bone marrow? New work from the @mzhlab complements recent findings from the @TheColonnaLab and @jonykipnis labs to show brain-dedicated B-lymphopoiesis! A pleasure to contribute our little grain nature.com/articles/s41593-0…

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Jeremy Gungabeesoon retweeted
It’s out! My PhD work focusing on toxicities associated with anti-cancer immunotherapy drugs: immunology.sciencemag.org/co… And my first #tweetorial brought to you by @PittetLab where you can learn all about our findings! x.com/PittetLab/status/14116…

0/ Published today in Science Immunology! Work from our lab investigating immunotherapy-driven toxicities (immune related adverse events, a.k.a. irAEs), which are a major clinical problem in cancer immunotherapy clinics. #tweetorial immunology.sciencemag.org/co…
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Jeremy Gungabeesoon retweeted
A new @MGH_RI, @harvardmed study pinpoints a potential target to offset adverse effects from #cancer #immunotherapy, revealing in mice that obstructing inflammatory neutrophils in the liver prevented the toxicity of anti-CD40 agonist therapy: fcld.ly/j1e5xr4
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Jeremy Gungabeesoon retweeted
👉Macrophages & neutrophils may drive toxicities after #immunotherapy, but NOT dendritic cells. Instead, dendritic cells, incl. DC3 (also called, LAMP3 DC, mregDC) may be key for antitumor immunity. This could be important for next gen treatments. doi.org/10.1126/sciimmunol.a…
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Jeremy Gungabeesoon retweeted
0/ Published today in Science Immunology! Work from our lab investigating immunotherapy-driven toxicities (immune related adverse events, a.k.a. irAEs), which are a major clinical problem in cancer immunotherapy clinics. #tweetorial immunology.sciencemag.org/co…

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Jeremy Gungabeesoon retweeted
Pleased to announce my latest study @RockefellerUniv published in @ScienceTM. stm.sciencemag.org/content/1… In this study we provide proof of concept for bladder infused CD40 agonistic antibodies as a local treatment for bladder cancer.

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Jeremy Gungabeesoon retweeted
Low-carb, high-fat diets—including the popular “ketogenic” diet—may not be any more effective at keeping obesity at bay than those that balance calorie intake with energy expenditure, a new #SciencePerspective suggests. fcld.ly/oeb435c #WeekendReads

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Jeremy Gungabeesoon retweeted
👉The @PittetLab is hiring a #bioinformatician to pursue our work on the tumor immune microenvironment. All this in an amazing place isrec.ch/en/agora 🇨🇭... and with a great bioinformatics network @KleinLabHMS @carmonation ! Please share or let us know if interested!
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Jeremy Gungabeesoon retweeted
In their #JEMCancerFocus review, @gengerhard @PittetLab et al reveal the conservation of human tumor-infiltrating dendritic cell states, explore DC state conservation in mice, & discuss the origins, behavior & functions of these cells bit.ly/2LQ0pqv
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Jeremy Gungabeesoon retweeted
😀Happy to share our latest work on tumor-infiltrating dendritic cells (DC)! doi.org/10.1084/jem.20200264 We know these cells can play key antitumor functions, but they require more attention and could become important targets for cancer #immunotherapy. @MGHCSB @MGH_RI @harvardmed 1/n
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Jeremy Gungabeesoon retweeted
The Harvard Medical School Immunology Webinar Series kicks off the Fall program this Wed Sep 2nd, 4pm EST with Dr Joanne Flynn. Check out the full schedule: dms.hms.harvard.edu/immunolo… Zoom link: harvard.zoom.us/j/9495334099… Passcode: 840345 Open to all- please retweet!
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