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Jan-Hannes Schäfer @jhschaef

Archive only. Find me where the sky is blue for more: jhschaef.bsky.social

Joined January 2021
  • Tweets 30
  • Following 428
  • Followers 223
10 Photos and videos
Our Structure of the yeast Ceramide Synthase is now out @NatureSMB! Thanks to all involved from @FlorianFrhlich3 and @MoellerGroup. rdcu.be/dZRn9 #cryoEM #uos

Jan-Hannes Schäfer@jhschaef
25 Oct 2023
Preprint Alert! 📣We've solved the first structure of a Ceramide Synthase. Great Team work @FlorianFrhlich3 @MoellerGroup @DJanuliene @UniOsnabrueck Thanks to co-first Lena Clausmeyer & Carolin Körner! #uos #cryoEM #openscience doi.org/10.1101/2023.10.24.5…
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Happy to see another chapter of my PhD work on yeast SPT-Orm2 out at @CellReports. Thanks to all involved! doi.org/10.1016/j.celrep.202… #lipidtime #cryoEM

Jan-Hannes Schäfer@jhschaef
31 Jan 2024
Our #lipidtime story continues with yeast SPT-Orm2! Great team-work with co-first Carolin Körner from @FlorianFrhlich3. @MoellerGroup @DJanuliene @krparey and @teislab Oliver Schmidt. #b3d #cryoEM Have a look doi.org/10.1101/2024.01.30.5…
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Happy to have contributed to solving Gaucher's disease GCase-LIMP-2 complex. Congrats to first Jan Philipp Dobert from Zunke-lab & Arnold-lab and all others. @MoellerGroup @Molecular_Neuro researchsquare.com/article/r… #b3d #cryoEM
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Our #lipidtime story continues with yeast SPT-Orm2! Great team-work with co-first Carolin Körner from @FlorianFrhlich3. @MoellerGroup @DJanuliene @krparey and @teislab Oliver Schmidt. #b3d #cryoEM Have a look doi.org/10.1101/2024.01.30.5…
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Preprint Alert! 📣We've solved the first structure of a Ceramide Synthase. Great Team work @FlorianFrhlich3 @MoellerGroup @DJanuliene @UniOsnabrueck Thanks to co-first Lena Clausmeyer & Carolin Körner! #uos #cryoEM #openscience doi.org/10.1101/2023.10.24.5…
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Update: Congrats to @DavidBSauer and team for solving human CerS6 doi.org/10.1101/2023.12.02.5… - Who knew, its a "ping-pong" mechanism!
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Update: Nice work from Xin Gong on homo-dimer of yeast CerS on EMBO doi.org/10.15252/embj.202311…

Structure and mechanism of a eukaryotic ceramide synthase complex

The EMBO Journal - Ceramide synthases (CerS) catalyze ceramide formation via N‐acylation of a sphingoid base with a fatty acyl‐CoA and are attractive drug targets for treating numerous...

link.springer.com
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Our paper on "Structure of the ceramide-bound SPOTS complex" is now out in @NatureComms - Fantastic teamwork with co-first Carolin Körner from @FlorianFrhlich3 nature.com/articles/s41467-0… @MoellerGroup #CryoEM #UOS 🔬❄️
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The yeast SPOTS complex involves Sac1 🟣 and is bound to ceramide and ergosterol. Let's find out more about this cross-talk between the membrane code and protein activity.
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That is a first for me on our Glacios. No ApoF. Friday #cryoEM goals unlocked 🍩 #uos @MoellerGroup
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🚨Check out our new #preprint. Happy to have contributed! Great colab @UngermannLab @KuemmelLab @MoellerGroup and the Paululat lab! #OpenScience
bioRxiv@biorxivpreprint
2 Mar 2023
Regulatory sites in the Mon1-Ccz1 complex control Rab5 to Rab7 transition and endosome maturation biorxiv.org/cgi/content/shor… #bioRxiv
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The paper is finally published in PNAS! Have a look. pnas.org/doi/10.1073/pnas.23…

Regulatory sites in the Mon1–Ccz1 complex control Rab5 to Rab7 transition and endosome maturation |...

Maturation from early to late endosomes depends on the exchange of their marker proteins Rab5 to Rab7. This requires Rab7 activation by its specifi...

pnas.org
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Happy to have contributed to our latest paper with @UngermannLab @LarsLangemeyer @MoellerGroup spearheaded by Twitterless Sophie Grziwa. Yck3 regulates membrane trafficking by phosphorylating I-BAR protein Ivy1. doi.org/10.1242/jcs.260889
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There is quiet nothing like sharing a new structure! "Structure of the metazoan Rab7 GEF complex Mon1-Ccz1-Bulli" form @MoellerGroup now out in PNAS. Fantastic collaboration with co-first @stEricHerrmann and @StephanWilmes from @KuemmelLab and @UngermannLab. #cryoEM #UOS #b3d
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Have a look: pnas.org/doi/10.1073/pnas.23…

Structure of the metazoan Rab7 GEF complex Mon1–Ccz1–Bulli | PNAS

The endosomal system of eukaryotic cells represents a central sorting and recycling compartment linked to metabolic signaling and the regulation of...

pnas.org
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Thrilled to share our new @biorxivpreprint: "Structure of the ceramide-bound SPOTS complex" from @MoellerGroup @DJanuliene @krparey. Great collaboration with @FlorianFrhlich3 lab, spearheaded by Carolin Körner. #CryoEM biorxiv.org/content/10.1101/…
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