This has been my experience, especially in the last frew months. I have never used UpToDate's AI, but OE vs ChatGPT tends to favor ChatGPT in my hands

As a result of a US government directive, we are suspending access to Claude Fable 5 for all users. You can continue to use all other Claude models. Here’s what this means for you: Across Claude products, new sessions will run on your selected default model or Opus 4.8, and existing Fable 5 sessions will end with an error. On the Claude Platform, requests to Fable 5 will also return an error. Please update your integrations to other Claude models. We know this is a disruption to your workflows; we appreciate your patience and support.

Estados Unidos ha prohibido que los extranjeros, incluidos los que viven legalmente en Estados Unidos, usen Fable 5 o Mythos 5. En consecuencia, Anthropic ha cortado todo acceso al modelo. Estamos jodidos

Daniel Kahneman - the psychologist who won a Nobel in economics - spent his life proving one thing: your confidence is lying to you A bat and a ball cost $1.10. The bat costs $1 more than the ball. The answer "10 cents" jumps to mind instantly. It's wrong (it's 5 cents) - and ~50% of students at Harvard, MIT and Princeton say it without checking. That gap is his whole point: the fast, intuitive mind builds a clean story from almost nothing, and the feeling of certainty has nothing to do with being right. "Confidence is a feeling, not a judgment." "Stock pickers can't develop intuition - there isn't enough regularity for it to form." "You can build a very coherent story out of very little information." ~45 min, free. how your mind fools you - from a man who studied it for 50 years ↓

The fact that Anthropic may take away subscription access to Fable in two weeks is weird & discourages investing in learning about the model. Subscription use is how you figure out what the model is good for, since it allows experimentation. Only having paid access is limiting.

This is a super exciting release - Claude Fable 5 is the same underlying model as Mythos but with added safeguards. The benchmarks are great and it's SOTA on everything by a margin but I'll add that *qualitatively* also, this is a major-version-bump-deserving step change forward (imo of the same order as Claude 4.5 was in November), peaking especially for long problem-solving sessions on very difficult problems. You can give it a lot more ambitious tasks than what you're used to, the model "gets it" and it will just go, and it's never felt this tempting to stop looking at the code at all (but don't do this in prod!). The model still has quirks that people will run into and the safeguards are configured to be a little too trigger happy for launch, which can hopefully be tuned over time. I feel a lot of things changing as working software increasingly comes out on a tap. The Jevon's paradox kicks in and I feel my own demand for software growing substantially. You can ask for anything - explainers, visualizers, dashboards, bespoke single-use apps (e.g. a full wandb that is hyper-specific just for your project), you can 10X your test suite, auto-optimize code, run giant research projects with custom HTML for the results, anything! "Free your mind" (Matrix ref). Really looking forward to all the things people build!

HABEMUS MYTHOS El modelo de IA más potente del mundo llega al gran público con el nombre Fable 5 y salvaguardas que limitan su capacidad en ciberseguridad, biología y química, y destilación Disponible hasta el 22 de junio para cuentas Pro, Max, Team y Enterprise. Después...

Introducing Claude Fable 5: a Mythos-class model that we’ve made safe for general use. Its capabilities exceed those of any model we’ve ever made generally available.

1 - Arnold #Schwarzenegger entregando el premio Irving G. Thalberg a #ClintEastwood en los Oscars de 1995 👏🏻👏🏻

Aprovechando el cumpleaños del GRAN #ClintEastwood 🎂 vamos con un HILO 🧵 actualizado de los videos que he subtitulado hasta la fecha sobre una de las más grandes leyendas cinematográficas 🙌🏻 Gracias por tanto, Clint y FELICES 96 AÑOS!! DENTRO HILO!! ⬇️⬇️⬇️

Shakira is the only artist in history to receive a tribute from the a cappella band Out of the Blue, at Oxford University.

Solo un filósofo como Slavoj Žižek sabría conectar la Inteligencia Artificial, el sexo y el descenso de coeficiente intelectual que está dándose en todo el mundo desde 2010.

Los médicos de Canarias anuncian la suspensión de la actividad voluntaria en hospitales públicos a partir del 8 de junio laprovincia.es/canarias/2026… a través de @laprovincia_es

SOHO trial in NEJM: 🏙️ Multicenter RCT comparing high-flow nasal cannula vs. low-flow oxygen among patients with acute hypoxemic respiratory failure (mostly pneumonia) 🏙️ Inclusion criteria required a respiratory rate >25 and substantial hypoxemia (P/F <200) 🏙️ No difference in the primary endpoint of mortality (not surprising, the mortality endpoint is nearly always neutral in modern RCTs evaluating the nuances of supportive care). 🏙️ HFNC reduced the rate of intubation and increased the number of ventilator-free days. 🏙️ No significant signals of harm from HFNC. This is similar to the FLORALI trial (by the same group of investigators). However, FLORALI showed *improvement* in mortality, whereas the current study didn't. Why do these studies disagree about mortality? The FLORALI trial found no mortality difference between HFNC versus conventional oxygen among ALL PATIENTS. However, it DID find a mortality difference in the *subgroup* of patients with P/F <200. So this is a classic tale in critical care - a subgroup analysis from one trial subsequently fails to replicate. (At least, in terms of the mortality benefit.) But chasing mortality in these trials is a fool's errand. Overall, the SOHO trial still supports the use of HFNC in acute hypoxemic respiratory failure (in terms of reduced intubation and improved ventilator-free days). Using HFNC for sick pneumonia patients is already standard care, so I don't see this changing practice very much. Keep calm and HFNC on. 🌬️

Have you ever heard of the Eagle effect? When more kills less. One of microbiology's most intriguing paradoxes: sometimes higher antibiotic concentrations result in less bacterial killing. This phenomenon has even been proposed as a potential rationale for combination therapy.

La infectóloga que acaba de huir a Suiza porque en España todavía no existe su especialidad elconfidencial.com/salud/202…

Bundibugyo ebolavirus outbreak in the Democratic Republic of the Congo and Uganda: rapid assessment from the ESCMID Emerging Infections Subcommittee @CMIJournal @ESCMID clinicalmicrobiologyandinfec…

📣 New publication: First reported case of Andes hantavirus cardiopulmonary syndrome treated with a combination of favipiravir, ribavirin, icatibant and baricitinib: clinicalmicrobiologyandinfec… #hantavirus

🚨 New Epi Alert this week: updates on the ebola (Bundibugyo virus) outbreak in DR Congo and the cruise ship hantavirus outbreak. Measles transmission continues worldwide with Peru declaring a health emergency. More: ow.ly/9HJm50Y3Qs0

Aparecido en una planta del hospital. Sin título nº 47, anónimo aragonés, ca. 2024. Técnica mixta sobre falso techo. Falta firma para cotizar alto. #HospArt #FalsoTecho