melanoma oncologist @mskcancercenter I clinical trials, cellular therapy & translational immunotherapy research | n.b.: personal account

Joined August 2010
36 Photos and videos
Jim Smithy retweeted
An experimental vaccine from Moderna shows promise in keeping deadly skin cancer from returning for years, according to new clinical trial results. nbcnews.com/health/cancer/peโ€ฆ
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*fantastic* PFS data for darovasertib & crizotinib in HLA A 02:01 negative metastatic uveal melanoma โ€”huge step forward in an area with immense unmet need ๐Ÿ‘๐Ÿผ ๐Ÿ‘๐Ÿผ ๐Ÿ‘๐Ÿผ #ASCO26
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Today at #ASCO26: MSKโ€™s @jsmithymd shared his rapid oral abstract โ€œA phase 2 trial of IO102-IO103 and nivolumab-relatimab in previously untreated, unresectable #melanoma.โ€
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Join MSK melanoma medical oncologist Dr. @jsmithymd at #ASCO26 as he presents results from a phase 2 trial evaluating IO102-IO103 in combination with nivolumab-relatlimab in patients with previously untreated, unresectable melanoma. ๐Ÿ•’ Saturday, May 30 | 5:36 p.m. CDT Learn more: bit.ly/4u73WQz
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a translational tour de force covering the last 15 years in melanoma therapy by dr antoni ribas; immense progress but still lots of work to do ๐Ÿงฌ ๐Ÿงซ @MSKCancerCenter
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Jim Smithy retweeted
๐—ง๐—ต๐—ฒ ๐—ช๐—ผ๐—ฟ๐—น๐—ฑ ๐— ๐—ฒ๐—น๐—ฎ๐—ป๐—ผ๐—บ๐—ฎ ๐——๐—ฎ๐˜† ๐—š๐—น๐—ผ๐—ฏ๐—ฎ๐—น ๐—ฆ๐˜†๐—บ๐—ฝ๐—ผ๐˜€๐—ถ๐˜‚๐—บ continues with a series of expert-led sessions and presentations, featuring leading clinicians and researchers who highlight emerging therapies, share real-world clinical insights, and explore strategies to advance early detection and improve outcomes in melanoma care worldwide. ๐—๐—ฎ๐—บ๐—ฒ๐˜€ ๐—ฆ๐—บ๐—ถ๐˜๐—ต๐˜†(@jsmithymd) discussed emerging cell therapy platforms for advanced melanoma, highlighting innovative adoptive cell therapies and next-generation immune-based strategies that are expanding treatment possibilities for patients with refractory disease. ๐—ญ๐˜‚๐—น๐—ณ๐—ถ๐—พ๐˜‚๐—ฒ๐—ฟ ๐—ข๐˜๐˜๐˜† reviewed current approaches to first-line therapy of metastatic melanoma, focusing on treatment selection, immunotherapy combinations, and factors guiding personalized management in clinical practice. ๐—”๐˜…๐—ฒ๐—น ๐—›๐—ฎ๐˜‚๐˜€๐—ฐ๐—ต๐—ถ๐—น๐—ฑ shared perspectives on how melanoma is treated across Europe, outlining regional practices, evolving therapeutic standards, and the integration of novel systemic therapies into routine care. ๐—ญ๐—ฎ๐—ต๐—ฟ๐—ฎ ๐— ๐—ผ๐—ต๐—ฎ๐—บ๐—ฒ๐—ฑ ๐—”๐—ต๐—บ๐—ฒ๐—ฑ explored the challenges encountered when clinical guidelines meet real-world practice, emphasizing practical decision-making, resource considerations, and adapting evidence-based recommendations to diverse patient settings. More insights continue to emerge as the OncoDaily Global Symposium unfolds ๐ŸŒ ๐Ÿ”ด Live sessions available here: youtube.com/live/7TDHWCyn724โ€ฆ x.com/i/broadcasts/1nxnRYQeAโ€ฆ #OncoDaily #Cancer #Oncology
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looking forward to a great day of discussion on solid tumor cell therapy at iwCART & sharing updates on PRAME-targeted TCR-T in advanced melanoma
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Jim Smithy retweeted
Among patients with immune checkpoint inhibitorโ€“related cutaneous adverse events, dupilumab therapy was associated with lower 5-year mortality compared to no dupilumab or systemic corticosteroids. ja.ma/4167rLa
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Ellen was diagnosed with a rare and hard to treat #ovariancancer. Everything changed when she enrolled in a clinical trial led by Dr. Rachel Grisham, based on a lab discovery years ago by @DSolit. Watch more #SavedbyScience stories on YouTube: bit.ly/3ZLODjv
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thatโ€™s a wrap on melanoma bridge! three days tackling the most pressing questions in the field with an inspiring roster of speakersโ€ฆ thank you @PAscierto & colleagues for organizing
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More than a year after receiving a type of immunotherapy called tumor-infiltrating lymphocyte (#TIL) therapy, Pattie is doing well and has almost no signs of metastatic #melanoma Learn more from @jsmithymd, a melanoma medical oncologist and cellular therapist at MSK and expert in #TILtherapy. bit.ly/3X9yBP0
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Jim Smithy retweeted
Published by โฆ@OncNewsCentralโฉ | I had a great conversation with Dr โฆ@jsmithymdโฉ & Dr Michael Postow on the latest in #Melanoma #Immunotherapy & #MolecularlyTargetedTherapy - Navigating Options โฆ@MoffittNewsโฉ โฆ@MSKCancerCenterโฉ oncologynewscentral.com/videโ€ฆ
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Jim Smithy retweeted
Scientists conducting medical research are facing an existential crisis: Layoffs and budget cuts pushed by President Trump that, they say, jeopardize finding a cure for cancer. Ted Koppel talks with cancer patients taking part in clinical trials for treatments and vaccines, whose own contributions to finding a cure are imperiled.
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Jim Smithy retweeted
Underway now in the #melanoma rapid oral abstract session at #ASCO25: Sarah E. Lochrin, MBBCh (@LochrinSarah) from @MSKCancerCenter shares interim results from the C-IT Neo trial on single-dose neoadjuvant ipilimumab nivolumab in resectable melanoma, with CD8 PET imaging. โžก๏ธ 59% major pathologic response after one dose โžก๏ธ Grade โ‰ฅ3 treatment-related AEs in just 9% โžก๏ธ CD8 PET tracer uptake correlated with IHC, but not predictive of response #Immunotherapy #Neoadjuvant @ASCO #MoffittASCO25
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Jim Smithy retweeted
Congratulations to Kathryn Arbour @KCArbourMD and colleagues showing activity of BMS-986504 in MTAP-deleted solid tumors, including lung and pancreas cancer. @MSKCancerCenter
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Melanoma oncologist @jsmithymd speaks to attendees of @ASCO about his research during poster sessions at #ASCO25.
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fun morning at the melanoma poster session sharing our data on post-discharge toxicity for patients treated w lifileucel at MSK! many great abstracts across the spectrum of melanoma care #ASCO2025 @MSKCancerCenter
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Jim Smithy retweeted
28 Apr 2025
Super proud of @AliToth_ on excellent presentation @AANSNeuro @NSTumorSection & Master's eval'ing radiomic features vs multidisciplinary consensus in predicting #CNS #melanoma post-RT recurrence vs necrosis/heme. ๐Ÿšจ2026 nsgy applicant alert-she will match highly! @BrainMets_MSK
Incredible work and an incredible job presenting her research from her research year at MSK! An amazing future neurosurgery applicant. @AliToth_ #AANS2025
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