Upgrading my Alfred with some useful gemma 4 local LLM workflows.

Took the plunge and upgraded from my 32gb m2 max to 128gb m5 max MacBook Pro. So now I can finally run 100 Chrome tabs. 🥲

Counterargument: Artisanal, handcrafted, organic knowledge is like $30 farm-to-table avocado toast—a delicious affectation for the upper [intellectual] class; probably not the way to feed the world.

Now we just need native HTML rendering in Telegram.

You don't say? 🤔

While my attempts at AI automation often feel like they take up more time than it actually saves me, it's also an incredibly addictive experience.

Felt inspired by this list and had my agent create this site: gigafucked-landing.vercel.ap…

Unsubscribed from Claude Max today. Let's see if I can last.

If this gets openclaw support it'll be an instabuy for me 😎

I wanted to share something I built over the last few weeks: isometric.nyc is a massive isometric pixel art map of NYC, built with nano banana and coding agents. I didn't write a single line of code.

GLP-1 drugs have intrinsic potent anti-inflammatory action beyond their metabolic beneficial impact on glucose regulation and weight loss @DanielJDrucker @jclinicalinvest jci.org/articles/view/194751

Neat! Now you can just walk into Walmart if you have a prescription (easily acquired) and get a pen of tirzepatide for $349 for a month's supply at 2.5 mg or $499 for a month of any other dose level Looks like getting obesity drugs is becoming less expensive and more convenient

Women derive more benefit from physical activity than men with respect to reduction of cardiovascular risk and related mortality, and can achieve protection at lower levels of engagement. From ~85,000 participants, open-access (blue=men) nature.com/articles/s44161-0…

There’s a name for a diagnostic test that’s 42% sensitive and 83% specific: useless.

As a neurosurgeon I care a lot about road safety. By now you’ve probably seen @Waymo’s stunning safety results (like 91% fewer serious crashes). But they didn’t just publish data headlines. They released the raw CSV files and data dictionaries. I did a much deeper analysis. A fascinating story emerges when you analyze how they’re achieving this. This isn’t incremental improvement - it’s categorical. We’re looking at the potential elimination of traffic deaths as a leading cause of mortality. The intersection breakthrough: Waymo has essentially solved intersection crashes, with 95% fewer injury incidents than human drivers in the same locations. That’s transforming the deadliest driving scenario. The national math: If every US vehicle performed like Waymo, we’d prevent 33,000-39,000 deaths annually and save $0.9-1.25 trillion in societal costs. Even partial adoption at 27% would save ~10,000 lives per year. In terms of magnitude, this would be the equivalent of eliminating every pedestrian death nationally in a year. The physics signature: Here’s what fascinates me: 47% of Waymo’s contacts involve less than 1 mph delta-V. They’re not just avoiding crashes; they’re converting unavoidable incidents into gentle bumps. It’s like having physics itself on your side. We’re not talking about marginal safety gains. The data represents a fundamental shift from harm reduction to harm prevention. The methodology matters: I used their dynamic geographic benchmarks (comparing like-for-like road conditions) and verified the findings hold across San Francisco, Phoenix, LA, and Austin. The safety advantage actually increases in more complex urban environments. Link to raw data below…. Notes on my approach: Analysis based on 96 million miles of Waymo Rider-Only (RO) data through June 2025, utilizing Waymo's dynamic geographic benchmarks to compare Waymo Driver performance against human drivers under similar road conditions and operational design domains. The projections for national impact (deaths prevented, societal costs) involve several assumptions. Given Waymo's zero reported fatalities, the direct serious injury reductions were mapped to national fatality statistics using established NHTSA-derived ratios that correlate serious injury crash rates with fatality rates. This extrapolation assumes that Waymo's observed serious injury prevention capability would translate proportionally to fatality prevention. Societal cost savings are estimated by applying average per-fatality and per-injury economic costs (e.g., medical, lost productivity, quality of life) as published by NHTSA, scaling these national averages to the projected number of avoided fatalities and injuries based on Waymo's safety performance. These figures represent the potential annual impact if the Waymo Driver's safety profile were widely integrated into the national fleet. @ethanteicher

Grip strength predicts who thrives into their 80s and 90s. Even your handshake predicts your future

New article by me! Cardiovascular disease mortality rates have declined by around three-quarters since 1950, but we rarely hear about it. I explore some of the reasons behind the decline.

My thoughts on China, export controls and two possible futures darioamodei.com/on-deepseek-…