ALT A schematic representation of HTT’s multifunctionality in the autophagy–lysosome pathway. HTT interacts with ULK1, aiding its recruitment to donor membranes containing PI4,5P2 and ATG9, leading to phagophore nucleation, and LC3–I conjugation to LC3–II. HTT can interact with p62 for cargo recruitment of cellular debris, damaged organelles, and ubiquitinated proteins. Subsequently, HTT associates with autophagosomes and late endosomes, likely acting in concert with RAB7 for microtubule–dependent transport to lysosomes following STX17–mediated fusion. Finally, HTT is implicated in lysosome fusion with both autophagosomes and amphisomes for the degradation of cellular cargo.