To solve aging, we first need to measure it. Excited to share our study in @NatureMedicine! Different cell types age at different rates within our body. From a tube of blood, we track aging across 40 cell types, from immune cells to neurons, revealing signatures that forecast disease risk and resilience. @wysscoray 🧵1/9

Female Clinical Resilience Despite Pathologic Risk in Alzheimer's Disease jamanetwork.com/journals/jam…

Liu et al. report that soluble Aβ monomers are strongly associated with cerebral amyloid angiopathy in plaque-free human brains, whereas cognitive decline relates more to aggregated or extended Aβ forms. 👉 doi.org/10.1093/braincomms/f… #braincommunications #neuroscience #amyloid

New paper out in Glia! Male and female mice regulate their sleep-promoting VLPO astrocytes very differently across the day. 👉 pubmed-ncbi-nlm-nih-gov.insb… #Sleep #Glia #Astrocytes #Neuroscience #VLPO #SexDifferences #CalciumImaging #Circadian @CirbCdf

HERE IS WHY: Autoantibodies against Cytokines — From Infection to Inflammation | New England Journal of Medicine nejm.org/doi/10.1056/NEJMe26…

Hyperglycosylation is a metabolic driver of Alzheimer’s disease | Nature Metabolism nature.com/articles/s42255-0…

Identifying an inflection point for Alzheimer's disease from the brains of 80 and 100 year old individuals. Microglia transition is key; initially it is protective vs inflammatory changes triggered by amyloid. But microglia can turn destructive linked to tau. Resilience in older age, via two divergent pathways, prevents that transition. @NatureMedicine nature.com/articles/s41591-0…

Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties: Neuron cell.com/neuron/fulltext/S08…

Human microglial transitions at the Aβ–tau inflection point associate with divergent pathways to dementia and resilience nature.com/articles/s41591-0…

A new Hormone Cell Atlas maps where hormones are made and received across 47 human tissues using 14 million single cells. The resource reveals unexpected hormone-producing cells, endocrine feedback networks, and new insights into metabolic and endocrine disease. #Endocrinology #SingleCell #PrecisionMedicine science.org/doi/10.1126/scie…

You guys this website is crazy Pick any signaling pathway or metabolite or whatever, see everything it's involved with in an interactive map, download a pdf, whatever reactome.org/

New paper in @GreenJournal! We investigated whether future AD dementia can be predicted in individuals with subjective cognitive decline. We found that plasma p-tau217, cognitive testing, and APOE ε4 status accurately identify those at highest risk. neurology.org/doi/pdf/10.121…

Patients with iatrogenic cerebral amyloid angiopathy (CAA) exhibit higher amyloid burden and a distinct biomarker profile compared with those with sporadic CAA, supporting a divergent—possibly exogenous—mechanism of amyloid propagation: hubs.la/Q04jpnCB0

Do NOT use Sci-Hub, the evil website that pirated 88M research papers. It also integrates with Zotero. We must make billion-dollar, for-profit, academic publishers richer. Below is a step-by-step tutorial on how to add Sci-Hub to Zotero, so you know how to avoid it:

RT @renesugar: Epstein-Barr Virus Antibodies to Differentiate Multiple Sclerosis From Other Neuroinflammatory Diseases #EBV #MECFS #LongCov…

#Parkinsons with and without detectable pathological α-synuclein (αSyn-SAA) are remarkably similar. What does that mean for the idea that α-syn aggregates "biologically define" PD? My take on a new #PPMI analysis: linkedin.com/posts/alberto-e…

TPPP, a protein that aggregates with α-synuclein, can form fibrils. Their concentration in CSF distinguishes MSA from PD and related disorders. @FudanUniversity @CAS_Science ow.ly/rVi750Z5PMV

And this tour de force, comprehensive new review of Alzheimer's disease thelancet.com/journals/lance…

Depression as an early symptom and risk factor of dementia - a narrative review "Depression may represent an early manifestation of an underlying neurodegenerative process, act as a risk factor for the later development of dementia, or coexist with early-stage dementia, thereby complicating clinical assessment. Distinguishing between these scenarios remains a significant diagnostic challenge, particularly in older adults presenting with affective and cognitive symptoms." frontiersin.org/journals/psy…

Dr Alice Carstairs shares how leaving academia for science communications helped her explain dementia research with clearer, more accessible language. Watch or listen to the full podcast. pod.fo/e/41c85f