Postdoc @Marsonlab @GladstoneInst @UCSF | PhD in Virology with @jkagan1 @harvardmed | Interest in Mechanistic Immunology, Cell Biology, Synthetic Biology
Joined July 2021
- Tweets 389
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Pinned Tweet
22 Nov 2023
Ever wondered how inflammatory caspases recognize IL-1 cytokines for cleavage?
Read more in our new paper, a collaboration between @jkagan1 and @WuLabHarvard labs out today @Nature
See🧵👇
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@harvardmed @BostonChildrens @VirologyHarvard @HarvardMicro
nature.com/articles/s41586-0…
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Pascal Devant retweeted
Apr 27
More than thrilled to share that I’ve been promoted to full (tenured) Professor @harvardmed @Harvard. This only happened because of the hard work of many people, but I want to dedicate this promotion to my grandmas, Nonna Maria & Nonna Vevè. A #FirstGen thread 🧵 1/x
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Nature research paper: Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis
go.nature.com/41Kptmu
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Pascal Devant retweeted
New Lab Alert! I am thrilled to share that next month I am starting my new role as an Assistant Professor at The Wistar Institute. I am extremely excited to work with fantastic new colleagues at Wistar and collaborate with researchers across UPenn.
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Pascal Devant retweeted
Excited to share an amazing video on the NLRP3 inflammasome pathway generated by talented Ann from the Iwasa lab @janetiwasa @Ann_HuiLiu. It shows the real cryo-EM structures of the pathway from #NLRP3, #ASC, #caspase-1, #GSDMD, #IL-1b, to #NINJ1. #cryoem @LeXiao17 Enjoy
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Pascal Devant retweeted
Excited to share that my PhD work on ER mito contact sites is finally out at @MolecularCell! Big shout out to @stark2_d to take this across the finish line, and @YatrikShahLab and @LyssiotisLab for their guidance as always!
Feb 13
Online Now: BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes dlvr.it/TQxTPQ
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Tachykinin signaling defines distinct populations of glia in the enteric nervous system.
Excellent work by Anu Muppirala, Meena Rao and team @BostonChildrens @harvardmed @PiN_Harvard published today in @NeuroCellPress
cell.com/neuron/fulltext/S08…
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Pascal Devant retweeted
Together with Emma Dann, we are thrilled to present a massive new Perturb-seq atlas of 22M primary CD4 T cells, from 4 donors, across 3 timepoints – the result of a decade-long collaboration between the Marson (@MarsonLab) and Pritchard (@jkpritch) labs.
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Pascal Devant retweeted
29 Dec 2025
We are excited to share our new @CellCellPress paper revealing mechanisms of action of promising drugs against the helicase–primase of herpes simplex virus 1 (HSV-1) 🤩@HarvardMicro cell.com/cell/fulltext/S0092…
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Pascal Devant retweeted
16 Dec 2025
@biorxivpreprint Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells
biorxiv.org/content/10.64898…
@HyuncheolJung @pascal_devant @Marsonlab
@GladstoneInst @UCSF @jccarnevale
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Pascal Devant retweeted
15 Dec 2025
Another exciting paper from @GladstoneInst Genomic Immunology - check out our latest preprint on myeloid cell editing: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by @HyuncheolJung and @pascal_devant
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15 Dec 2025
Excited to share the first Co-First author manuscript from my postdoc in the Marson lab @GladstoneInst Great collaboration with @HyuncheolJung from @jccarnevale lab @UCSF on CRISPR editing and screening in primary human myeloid cells!
See tweetorial below!
biorxiv.org/content/10.64898…
15 Dec 2025
Another exciting paper from @GladstoneInst Genomic Immunology - check out our latest preprint on myeloid cell editing: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by @HyuncheolJung and @pascal_devant
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Pascal Devant retweeted
15 Dec 2025
Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells biorxiv.org/content/10.64898… #biorxiv_immuno
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Pascal Devant retweeted
3 Nov 2025
New preprint from the lab from PhD student Seb Grant. Started as a summer side project and developed into an exciting story.
Evolutionary convergence of a Pyroptosis-Apoptosis crosstalk drives non-canonical inflammasome signalling. biorxiv.org/content/10.1101/…
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Pascal Devant retweeted
3 Nov 2025
Check out our latest work led by two talented postdocs, Madhura and Chris @TheBourneImmuno. We find that CASP4/5 can cleave and activate CASP3/7, acting as initiators of both pyroptosis and apoptosis. Notably, both are needed for full pathogen defense! biorxiv.org/content/10.1101/…
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Pascal Devant retweeted
26 Sep 2025
meta-PAMPs: A new class of immunostimulatory molecules that control the ability of bacterial factors to operate as PAMPs. Jordan Jastrab reveals that wall teichoic acid (WTA) is a key regulator of inflammasomes and interferons during infection.
biorxiv.org/content/10.1101/…
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Pascal Devant retweeted
21 Aug 2025
#InterferonPower! Thrilled for our latest work @CellCellPress! With @dfrboehmer, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free link 👉 authors.elsevier.com/a/1leKG…
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Pascal Devant retweeted
3 Aug 2025
New review from our lab. Kudos to PhD student @SebGrant346534. 10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry jbc.org/article/S0021-9258%2…
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Pascal Devant retweeted
30 Jul 2025
Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more.
Kudos to Joon Choi for his exceptional work.
@harvardmed @BostonChildrens
royalsocietypublishing.org/d…
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16 Jul 2025
RT @ShiyuXia: In January 2026, I will be joining Berkeley @UCBerkeley as an Assistant Professor in the Department of Chemical and Biomolecu…
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Pascal Devant retweeted
4 Jul 2025
Chris's @TheBourneImmuno paper is online now. Huge thanks to @BookerMan_PSU for coordinating this special Juneteenth issue @ACSPublications ACS Bio & Med Chem Au. Congrats to our growing lab and all who contributed. Happy 4th everyone!! pubs.acs.org/doi/full/10.102…
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