Bioinformatician. ex-Whāngārā. New Zealand/Aotearoa. A/Prof. Overly fond of RNA. Kayaking. Fishing.

Joined April 2010
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Paul Gardner retweeted
Assessing the robustness of human ncRNA notation at HGNC biorxiv.org/cgi/content/shor… #biorxiv_genomic

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21 Nov 2024
science.org/content/article/… Time to migrate folks...

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Paul Gardner retweeted
Postdoc position focused on RNA degradation biology, CRISPR gene editing and Nanopore long read sequencing in my laboratory in Copenhagen: please spread to great candidates. candidate.hr-manager.net/App…
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Paul Gardner retweeted
In 1922, a group of scientists went to the Toronto General Hospital where diabetic children were kept in wards, often 50 or more at a time. Most of them were comatose and dying from diabetic ketoacidosis. Others were being treated by being placed on an extremely strict diet, which inevitably led to starvation. These children were essentially in their death beds, awaiting what was at that time, certain death. The scientists moved swiftly and proceeded to inject the children with a new purified extract of insulin. As they began to inject the last comatose child, the first one to be injected began to wake up. Then one by one, all the children awoke from their diabetic comas. A room that was full of death and gloom, suddenly became a place of joy and hope. In the early 1920s, Frederick Banting and Charles Best discovered insulin under John Macleod at the University of Toronto. With the help of James Collip, insulin was purified, making it available to successfully treat diabetes. Both Banting and Macleod earned Nobel Prizes for their work in 1923. In the same year, Banting, Collip, and Best decided to sell the insulin patent to the University of Toronto for $1. Banting famously went on to say, "Insulin does not belong to me, it belongs to the world."
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Paul Gardner retweeted
People usually think replication attempts in science are rare. Journals don't publish replications, so scientists don't do them. In reality there are countless replication attempts (and failures), it's just PhD students assume they did something wrong journals.plos.org/plosone/ar…
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Paul Gardner retweeted
Researchers find nearly 30% of papers “that stated significances (or their absence) are based on the presence of a single influential data point.” biorxiv.org/content/10.1101/…
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Paul Gardner retweeted
Early bird registration closes Tue 5th November #OHA2024 The 10th #OneHealth Aotearoa Symposium 📅3-4 December 2024 📍University of Otago Wellington 💻#AntimicrobialResistance, climate change, Te Ao Māori & more! Link: otago.ac.nz/conference/one-h…
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This looks like another poor ML method. No mention of correcting for seq similarity when splitting data & no mention of negative data (e.g. shuffled or non-genic). No wonder the accuracy metrics look impressive. doi.org/10.1093/bioinformati…
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In a world of everlarger datasets and accessible ML/AI I would expect #biocurators of reliable & robust to be in high demand. Curious to know if this is reflected at Genbank/ENA, PDB, GEO, PRIDE, Rfam, Pfam, etc.
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Paul Gardner retweeted
New Zealand Geographic has been an icon of environmental journalism for 35 years, but times are changing, and we need your help to survive. nzgeo.com/stories/we-need-yo… 🧵(1/3)
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29 Oct 2024
I'm off to learn Thai -- English is already too hectic for me.
28 Oct 2024
All languages covey information at a similar rate when spoken (39bits/s). Languages that are spoken faster have less information density per syllable! One of the coolest results in linguistics.
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27 Oct 2024
I'll reject excessive extrapolations from limited data very quickly!
All rejected papers share one common flaw: a weak discussion section. I know because I used to write them too. If you're stuck on the discussion section, wondering how to tie it all together, this is for you:
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Paul Gardner retweeted
Nowhere. It doesn’t appear on any maps I’ve looked at recently.
26 Oct 2024
Which country is this as seen from space?
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Paul Gardner retweeted
🧵 Bioinformatics faces a critical challenge: despite its importance, software quality often falls short due to the lack of proper development practices. In our latest paper, we advocate for improving software quality in bioinformatics through teamwork. doi.org/10.1093/bioinformati…

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Paul Gardner retweeted
The punishment for science misconduct is …. nothing. All these men are still running labs / paid professors.
List of high-level Alzheimer's researchers accused of credible fraud:🧵 #1 - Marc Tessier-Lavigne Genentech pointed out problems in his 2009 Nature paper in 2012. After an expose by @tab_delete, he had to resign from Stanford Presidency, but can still run lab and do research.
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Paul Gardner retweeted
💥💥💥New preprint 💥💥💥on the EuPRI resource. Where we reconstruct the motifs for 34,736 RBPs and study their function and evolution. Joint work with @ProfTimHughes (Toronto), Matt Weirauch, @LXandR_, Deb Ray, Kaitlin Laverty and many more. More details to come
Reconstructing the sequence specificities of RNA-binding proteins across eukaryotes biorxiv.org/cgi/content/shor… #biorxiv_genomic
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16 Oct 2024
For just 2% of GDP we can make significant progress on all of NZ's major challenges: economy, health, transport, inequality, education, ... an absolute bargain! @MBIEsci @NZNationalParty @nzlabour @nzscientists #GrowGERD
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Paul Gardner retweeted
Not too late to submit an abstract to #crispr2025 meeting in NZ! Please share! We can’t wait to see all you crispr enthusiasts in Christchurch.
Deadline Extension for Abstract Submissions Good news! The deadline for abstract submissions has been extended to Monday 28 October. This is your chance to showcase your research by submitting either an oral or poster presentation for CRISPR 2025. #crispr #crispr2025 #phage
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Paul Gardner retweeted
The Department of Computational Biology at Cornell is seeking applicants for a new faculty member to serve as departmental chair! academicjobsonline.org/ajo/j…

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