PhD✅

We have now written up a preprint on this! biorxiv.org/content/10.1101/… @theHumanBorch

It took 3 years, 4 rounds of reviews, 96 VISIUM samples, 10 cancer types, and 1 clinical trial, but it's finally out: The spatial landscape of Cancer Hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity Here's what's new 👇 cell.com/cell-reports/fullte…

🏆Congratulations to @rill_aina for winning a Molecular Oncology prize at the 2024 @CarrerasIJC Symposium, with her poster "Integrative single-cell multi-omics of CD19-CARpos and CARneg T cells suggest drivers of immunotherapy response in B-cell neoplasias"👏

Very honored to have received one of the Molecular Oncology Poster Session Awards last week from #IJCSymposium “Updates on Genetics and Epigenetics of Haematological Malignancies: From Knowledge to Applications” at @CarrerasIJC ✨

So i'm very happy to say that my very talented honours student has reimplemented the entire trajectory workflow in R, intersecting with @theHumanBorch's scRepetoire! Code is now live github.com/tuonglab/dandelio… but lacking vignette; will be up shortly!)

Published today @NatureBiotech: @CarlHJune and I reveal how CAR T cells are finally tackling solid tumors! @PennPPA @PennMDForum nature.com/articles/s41587-0…

🚀 New research alert! Dive into the single-cell multi-omics of CD19-CAR and CAR- T cells! A promising step in #CARTcell therapy for better outcomes! Led by @MerGuMu, @rill_aina & @trincadojl from @Menendez_Lab and my lab! Enjoy! cell.com/action/showPdf?pii=…

STAMP is OUT! Sequencing-free #singlecell RNA and Protein profiling. Game-changing approach for scalable and cost-efficient analysis of single cells. The future starts today! Amazing ⁦@LGMartelotto⁩ ⁦@DrJasPlummer⁩ biorxiv.org/content/10.1101/…

Brilliant ✨ #YoungResearchers Seminar yesterday with Aina Rill, from @eli_mereu’s lab! We have learnt more about her project "Integrative #SingleCell multi-omics of CD19-CARpos and CARneg T cells suggest drivers of immunotherapy response in B-cell neoplasias". Great work! 👏

📢Our lab at the @CarrerasIJC is looking for candidates for the competitive PhD INPhINIT incoming fellowship from La Caixa Foundation. We work on the application of #singlecell genomics and ML to improve cell-based immunotherapy in Myeloma and others B-cell neoplasms. Plz RT!🔁

Our multimodal model to combine TCR sequences with scRNA-seq is finally out. The most interesting part for me was observing a clear case where the combination of TCR sequence and cell state (RNA) preserved both clonotype and cell type information, leading to a more holistic cell representation that captures phenotype and functionality. We also decompose the contribution and importance of each modality. This was a really fun project spearheaded by @DrostFelix, whose amazing perseverance during a long review period, and collaboration with @schubert_benni and other fantastic collaborators, made it possible. Read the paper :nature.com/articles/s41467-0…

Enjoying the ISCO’24 conference at Barcelona and presenting our work in Alcoholic Liver Disease🧬

Really glad to see our work published in @Nature @CommsBio: nature.com/articles/s42003-0…. This analysis of 39 fragment screening experiments sets the scene for our future work on function prediction for ligand sites across the @PDBeurope. @gjbarton @bartongrp @stuartmac44 @CallumMIves

Excited to share my first first-author paper: T-FINDER! 🎉 We've crafted a super-sensitive TCR signaling reporter with an innovative antigen processing system. Explore how we identify unknown peptide:HLA ligands - Check it out here on @ScienceAdvances: doi.org/10.1126/sciadv.adk30…

Very happy to share our #singlecell #multiomics analysis of #MDS patients and clinical response to #HMA in @CRC_AACR @ManelEsteller Check it out!✨ aacrjournals.org/cancerresco…