Super excited to share my 1st first-author publication out today in @ScienceMagazine, in which we resurrect billion-year-old enzymes to study the evolution of Rubisco. Let me tell you how a 100 amino acid protein facilitated the rise of oxygenic life. science.org/doi/10.1126/scie…

Today marks a pivotal moment for Isomorphic Labs. We have secured $2.1 Billion in our second external funding round, led by Thrive Capital. They are joined at the table by Alphabet, GV and new investors MGX, Temasek, CapitalG and the UK Sovereign AI Fund. This milestone accelerates our ability to build the pioneering novel AI models that power our AI drug design engine (IsoDDE) and deploy them at scale: delivering scientific breakthroughs with a precision previously thought impossible, accelerating and expanding our pipeline of therapeutic programs toward the clinic. All with the ultimate goal of delivering life-changing new medicines to patients. Moving forward, we will scale our drug candidate pipelines across multiple therapeutic areas, expand our global footprint, and push the boundaries of frontier AI research to power our drug design engine. Deeply grateful to everyone sharing our vision to solve all disease with AI. Let’s build the future of medicine. Read the full announcement here: bit.ly/4v2OI03

Check out this job offer if you are a computational chemist and want to work at the cutting-edge of protein & enzyme design (or please share it with anyone who might be a good fit)!!

🌍 Exciting news! This summer, my group joins @mpi_marburg to create photoenzymes for solar energy conversion & carbon capture. With #ProteinDesign 🖥️ & #DirectedEvolution 🧬, we’ll push enzyme design to new limits for a sustainable future! #Hiring mpi-marburg.mpg.de/1497154/j…

Check out Beau‘s sick PhD work!! Finally out for the world to read

Glad to see my main PhD project finally out @NatureMicrobiol nature.com/articles/s41564-0… We show for the first time that a synthetic and engineered pathway can indeed exceed nature at one-carbon fixation.

Congrats to @Leo_Ernst_2 for successfully defending his PhD thesis @mpi_marburg !🎊🍾🎉🥳 The first doctor from the Rebelein lab.

The story of how I developed the first biocatalysts for convergent and stereoselective SNAr chemistry is out now in @Nature! A massive thank you to all of the contributing authors from @GreenGroupMIB and @LarrosaGroup 🤓 nature.com/articles/s41586-0…

Delighted to announce that 'Engineered enzymes for enantioselective nucleophilic aromatic substitutions' is out now in Nature! Congratulations to Tom, George and everyone else involved in this project! 🎉🎉🎉 nature.com/articles/s41586-0…

Two exciting papers about the the protection of nitrogenases from O2 by the ferredoxin Shethna protein II from the Tezcan doi.org/10.1038/s41586-024-0… and Einsle doi.org/10.1038/s41586-024-0… labs were published today by @Nature. Surprisingly both papers reveal superstructures of filaments.

Happy to share our story on evolution of protein quaternary structure! We discover an astounding variation in assembly across evolutionary timescales contrasted by strong functional conservation suggesting a significant role of non-adaptive processes nature.com/articles/s41467-0… 👇🧵

lets gooooo - congratz Johannes!

Check this out!! highly recommend being in Tobi’s lab - so much scientific freedom, resources, and career support!

We are looking for a postdoc - in a project on a UbiD like (de)carboxylase!

Lets talk about #acetyl-CoA! As central molecule in C1 metabolism, the efficiency of its assimilation determines yields. Read below about our Lcm as novel activity in the shortest O2 tolerant route to make pyruvate from acetyl-CoA while fixing #CO2! nature.com/articles/s41467-0…