From DNA to the brain. Occasionaly fatherhood, cycling, indie rock. No, Dad will not turn his music down.
Joined October 2014
- Tweets 17,029
- Following 2,824
- Followers 5,033
- Likes 25,994
1,656 Photos and videos
Pinned Tweet
May 2
I'm pleased to share our latest preprint: Combinatorial effects of gene dosage, polygenic background and environment on complex traits 🧵medrxiv.org/content/10.64898…
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Jonathan Sebat retweeted
May 28
New [Souaiaia et al. 2026 Nature] paper argues that there is "distinct genetic architecture in the tails of complex traits". Some of my thoughts:
I'm not a fan of framing traits as having distinct architectures at the extremes when it's not really what's going on
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May 28
I'm preparing a new talk. Here's one slide that I'm particularly proud of
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May 26
1/ We conclude this Twitter takeover spotlighting an upcoming symposium at #WCPG2026
“Advancing Psychiatric Genomics through Large-Scale African Cohorts” 🌍🧬
The session will highlight how African cohorts are reshaping psychiatric genetics globally
@MLCampbell @rockyestroud2
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May 25
B.S. MDs are the only people I know who are addressed as “doctor” by their co-workers. I know very few academic scientists who refer to themselves or their colleagues by their credentials. “Dr.” is used mainly as formal way of addressing someone who you have just met.
May 25
Medical Doctors: Hey, I'm the cardiologist keeping you alive, just call me Alex.
PhDs: Please refer to me as Dr. Monica, I did my thesis on ancient pottery.
Look, I know the word 'Doctor' comes from the Latin docere (to teach). I know academics had the title first and I have full respect for the grind. But why are they always the ones defending the title like their lives depend on it?
If someone screams "Is there a doctor on the plane?!" absolutely nobody is looking for a Doctor of Philosophy
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May 25
Trigger warning. Today's Press Play with @TheMadBrand is not suitable for parents that are still recovering from PBSSD (Post Baby-Shark Stress Disorder). My youngest is now a freshman in college and I'm still recovering from that earworm.
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May 20
Take a look at the “Behind-the-Scenes Journey” from the Editorial on Challenges and Strategic Insights of the DepGenAfrica study @depgenafrica as provided by @PGC_Africa’s Comm’s rep @jaredgmaina and colleagues 🛠️🚀
cambridge.org/core/journals/…
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Jonathan Sebat retweeted
May 19
Join us this July at the inaugural Gordon Conference on Neural Genetics and Epigenetics! We’re excited to bring together researchers across neuroscience, genetics, and epigenetics for an exciting lineup. #genetics #epigenetics #neuroscience
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Jonathan Sebat retweeted
May 18
Hello from the PGC Africa working group 👋 Today, we begin our takeover to share with you exciting happenings from the working group and its members🎉This takeover is proudly brought to you by @PGC_Africa Africa Comms and Outreach team. Stay tuned!
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May 16
A very nice commentary from @MariaChahrour on new studies on long read sequencing including ours. 🙂
May 15
Illuminating hidden genetic architecture in autism dlvr.it/TSYWnj
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Jonathan Sebat retweeted
May 12
A news reporter asked Michael Jordan if he thought the ’90s Bulls could beat LeBron’s Lakers.
MJ: Yes.
Reporter: By how much?
MJ: Two or three points.
Reporter: Why so close?
MJ: Most of us are almost 60 now.
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May 9
Maybe I won’t need to do lengthy Twitter threads about my own papers if I can trick @doctorveera into doing them 🤔
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Jonathan Sebat retweeted
If you want to know what 3′UTRs with long conserved sequence stretches do, check out our BioRxiv preprint doi.org/10.64898/2026.05.05.….
They form functional intermolecular 3′UTR-3′UTR interactions that enable co-folding of proteins to rapidly induce transcriptional programs.
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Jonathan Sebat retweeted
New work from us pooling together clinical sequencing data to identify large effect common risk variants for rare cancer types. This included a novel HLA locus that interacts with HPV infection to increase Anal Cancer risk.
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Jonathan Sebat retweeted
Buffering of gene dosage response curves for human complex traits dlvr.it/TSQXBN
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Jonathan Sebat retweeted
May 7
Population geneticists! Come work at 23andMe! New role just posted.
23andme.wd5.myworkdayjobs.co…
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May 7
I’m sure gut microbiome associations with TBIs on the football field have NOTHING to do with Papa John’s and Bud Light
May 6
Six (yes, 6) college football players with non-concussive head injury (NHI) and changes in their gut microbiome. No controls. What can you conclude from this?
Not this:
"Our results provide strong evidence for a link between NHIs and changes in the diversity and composition of the gut microbiome."
journals.plos.org/plosone/ar…
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Jonathan Sebat retweeted
May 6
This, from @MeganMolteni, is frickin' cool.
"How a global effort to explore the ‘dark proteome’ is upending our understanding of human disease."
I remember when everyone was shocked that there were only 30,000 protein-coding genes found by the Human Genome Project. This is why: there are all these layers of complexity with RNA and protein fragments "editing" that original script. It's far more complicated than geneticists imagined 25 years ago. Fascinating, daunting, and kind of a beautiful mess.
statnews.com/2026/05/06/dark…
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Jonathan Sebat retweeted
ADHD is highly genetic, but we still do not fully understand all the genetic factors involved.
A new large-scale study helps fill an important part of that gap.
#ADHD
#genetics
#psychiatry
#mentalhealth
nature.com/articles/s41586-0…
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