Dr. Tim Henrich presented new findings surrounding long term persistence of SARS-CoV-2 proteins & RNA in Long COVID gut tissue at PolyBio’s recent Spring symposium. “We actually see [gut viral persistence] in both areas, the epithelium—which turns over every several days to week—to the lamina propria where you have long-lived myeloid immune cells… suggesting there may even be replication in some individuals,” said Henrich. Using a highly sensitive method of detecting viral RNA, “around 20-25% of the time, we see detection… all the way up until 3-4 years after initial infection” in Long COVID patients.

Gas spent 20 years owning the evening peak. Batteries took a year to crash the party. That's disruption. Not gradual, but a rapid shift in who supplies grid's most valuable hours. The battle was never about total generation. It was about the peak & batteries are winning it.

Check out these talk summaries from our recent PolyBio Symposium👇 Highlights include that four groups — Tim Henrich (UCSF), Marcus Buggert (Karolinska), Nicolas Huot (Institut Pasteur), and Esen Sefik (Yale) — presented different lines of evidence (human gut biopsies, non-human primate models, humanized mice) all pointing to the same conclusion: SARS-CoV-2 persists in #LongCovid gut tissue and adjacent lymphoid structures, and that persistence drives ongoing immune dysregulation.

I have a first hand report that IMDUR has had a significant impact on a Long Covid patient of 1, who's symptoms were chest pain. It is symptom management, not cure but i'm wondering if others have any first hand data. #longcovid

2:30 pm ET—Michael Peluso outlined the structure of VIPER, PolyBio’s Long COVID biomarker validation program. UCSF’s PolyBio-supported LIINC program that collects blood & saliva samples from patients, as well as performs deep phenotyping, will send patient samples to several labs participating in VIPER’s network (pictured below). Prospective patient samples will be finalized in the Summer & sent out to labs this Fall.

Breaking: PolyBio Launches Commercialization Advisory Network to Accelerate Long COVID Diagnostics and Treatment PolyBio Research Foundation today announced the formal launch of its Commercialization Advisory Network, a new initiative designed to accelerate the translation of Long COVID and related chronic disease discoveries into clinical diagnostics and targeted treatments. polybio.org/polybio-launches…

Five years ago, she got COVID. By November 2021, she came to our clinic with disabling #LongCOVID symptoms. Today, for the first time in years, she told me she feels closer to her pre-COVID baseline. Closer to herself again. 🧵

Invisible Warfare Headline: The MIT Study that Finally Visualizes the Brain-on-COVID Have you ever had a medical scan come back "clear" while your brain felt like it was made of inflamed concrete? You aren't crazy. Standard medicine just wasn't looking small enough. A major 2026 paper from MIT and Harvard just changed the game. They didn't just look at brain tissue; they physically expanded it 15-20x its size—like using a molecular magnifying glass—to achieve 20-nanometer resolution. What they found changes everything: Standard imaging looks for damage. This paper visualized defense. Deep inside the brains of people who had SC2, they found periodic Amyloid Nanoclusters co-localizing directly with the virus. What does that mean? The Cargo: Your body is running on infected, hyper-activated platelets (the 'weaponized platelets' of LC). They carry viral debris and proteins into the brain's capillaries. The Body's Defense: When the brain detects these viral invaders, it doesn't wait. Its immune system (microglia/astrocytes) triggers a protective, antimicrobial "foam" called amyloid-beta. The Trap: This amyloid foam physically traps, cages, and neutralizes the viral proteins to stop them from causing further harm. The Price: The paper found a 2-fold increase in activated astrocytes, the cells that manage the brain's environment. These dense, sticky amyloid traps and swollen astrocytes create a state of permanent, local, architectural neuroinflammation. This isn't a "chemical imbalance." This is structural warfare. The brain is filled with tiny, persistent defensive knots that it cannot clear, causing the profound fatigue, cognitive impairment, and severe inflammation so common in LC. #LongCOVID #Neuroinflammation #Microbiome #VigilanceLab A comic showing this! Hope this helps my friends and fellow humans.

PJM is heading in the right way! Proposal under consideration: New Loads in PJM greater than 5 MW must either “BTONG” (Bring their own Generation) or contract directly (bilateral) with a new generator, or through the PJM RBP Auction for new capacity to meet their new load plus reserve margin.

PJM capacity prices have moved from US$28 to US$270 in a single auction. What happens when electricity demand, decarbonisation policy and affordability collide in the US power market: okt.to/fetwaZ 👇🧵

Running the math. What if, while we wait for battery costs to come down, we used mass produced engines (ie. 300HP Truck converted to NG) in a distributed network? Purpose designed for peaking, cost would come in < $750 per installed kW. Place them at industrial/commercial sites like you would batteries. Replace them in 7 yrs when battery costs are down. Math looks pretty compelling!

$ 2.8 Million Per MW - The economies of scale are gone. DG comes in at less than $2 per MW. We should mobilize us Industry to put generation at every plant where there is NG. 0h, and delivery times are shorter! - Simple business model - put behind the meter projects in with investor dollars, customers get backup power at no cost, customer pays prevailing rate, which offsets data center costs. DG better for the grid! it's the network model, stupid. Microsoft Corp. is in exclusive talks with Chevron Corp. and investment fund Engine No. 1 over a long-term deal for a giant energy complex in West Texas to power a large data center campus. The proposed natural-gas fired power plant is projected to cost about $7 billion and initially generate 2,500 megawatts of electricity, making it one of the largest of its kind in the US.

This is such a clear explanation of what we can do NOW to improve our electric capacity!. (and from a utility guy no less). Net metering for all, safe export flexibility, use of existing backup generators sitting idle when the grid is stressed. aol.com/videos/energy-consum…

6 years ago today I went on my last run (pic left) — today I’m 36 and I’ve spent my entire 30’s with #LongCovid struggling to walk up and down the block, or work more than 1-2 hours a day. Heres 4 things I never thought I’d lose at this age:

Lets solve this problem the smart way! So much can be done. Net metering for all. Multi year PJM auctions. Relaxed permitting on smaller NG generators. Etc. Jigar is spot on.

New report from PJM independent market monitor - PJM total wholesale power cost increased 50% from 2024 > 2025 ($56/MWh > $83/MWh) - Biggest contribution across components: energy prices ($33/MWh > $49/MWh, capacity $4/MWh > $13/MWh. Note first new spike in capacity prices kicked in during Q3 2025) - Average hourly day ahead offered supply decreased 2%, hourly cleared load up 3.7% >> we moved up the supply curve increasing energy prices and higher system utilization - Moving up the supply curve: in 2025, generation from oil up 30%, increased demand response calls alone increased LMP by 4% - There were 147 intervals with five minute shortage pricing in 2025 vs 39 in 2024 On both energy and capacity 2024 > 2025 is a sign of where we are headed next few years with an ever tightening market

This is the most inspiring long-term chart you’ll see. It also blows up all relentlessly wrong arguments about fossil fuels as somehow sacred in their ability to help drive growth. Now, what would be more inspiring is pushing all of this forward orders of magnitude faster:

Long COVID: The Hematologic System Long COVID can alter coagulation and vascular function, increasing hematologic risk. Documented concerns include blood clots, DVT, pulmonary embolism, stroke risk, platelet activation changes, and impaired clot breakdown. These vascular changes may contribute to fatigue, headaches, and organ-specific symptoms by reducing tissue oxygenation and perfusion. Clotting shifts raise special concern in pregnancy and other high-risk contexts where coagulation balance is already physiologically sensitive. Careful monitoring, early recognition of thrombotic symptoms, and prevention strategies remain essential to reduce risk and protect long-term health. We are all #OneInfectionAway Learn more about #LongCOVID and visit our #LongCOVIDAwareness Month page to take action, get involved, and spread the word! longhauler-advocacy.org/lcam… Access the video here: youtu.be/DdYPvgdz-4o