Scientist, educator, citizen, and father
Joined September 2018
- Tweets 235
- Following 148
- Followers 689
- Likes 469
13 Photos and videos
🦠Pathogenic bacterium Pseudomonas aeruginosa breaches lung defenses by targeting mucus producing goblet cells! Intracellular P. aeruginosa may evade immune system and antibiotic treatment, thereby driving chronic infections
@NCCR_AntiResist @IHB_Research doi.org/10.1038/s41564-024-0…
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11 Apr 2024
How to pick a problem. Today in @CellCellPress. 1/53
cell.com/cell/fulltext/S0092…
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So excited for our latest story on a tunable-spectrum antibiotic to be published. We desperately need microbiome-sparing strategies to treat P. aeruginosa. Amazing effort led by the fantastic @ConnorChain
9 Apr 2024
OUT NOW 📢: A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting @zgitai1
nature.com/articles/s41564-0…
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9 Apr 2024
OUT NOW 📢: A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting @zgitai1
nature.com/articles/s41564-0…
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4 Apr 2024
Phages snap TFP to prevent further infection!
Cool collab with labs of Lanying Zeng and Junjie Zhang @TAMUBCBP, Yiruo Lin @TAMU, Yinghao Wu @EinsteinMed, @shaevitz and @zgitai1 @PrincetonMolBio @phybiofunc, and our lab @TAMU_Biology
science.org/doi/10.1126/scie…
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3 Apr 2024
A big week for the lab! See terrific work by @AnnCirincione and Danny Simpson here 👇
3 Apr 2024
Excited to share our work in the @bsadamson lab using prime editing for multiplexed dropout screens! We built a platform that can reach high-efficiency editing and tested 240,000 epegRNAs for phenotypes. We saw phenotypes we expected and a few we didn't - check here for details!
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25 Mar 2024
The phiKZ jumbo phages build a protein based nucleus to protect their DNA(!), but what do they do before the nucleus is built? Led by outstanding post-doc @MozumdarDeepto, here we identify host and phage proteins in an immediate early phage lipid vesicle.
biorxiv.org/content/10.1101/…
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14 Mar 2024
Why are some non-antibiotic drugs toxic to bacteria 💊☠️🦠? Do they work like standard #antibiotics (ABX)? Our latest work by @MarianaNoto published @ScienceMagazine addresses this fundamental question (1/n)
science.org/doi/10.1126/scie…
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8 Mar 2024
New prepint alert @themaxwelllab! 📢 📢 📢 Superinfection exclusion (Sie) proteins aren’t just for defence – they also ensure the spread of viral progeny! Prophages that lack Sie proteins devour their young via a process we call the Kronos effect.
biorxiv.org/content/10.1101/…
ALT "Saturn devours his son" by Goya
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26 Feb 2024
A cool profile of me in @CurrentBiology sciencedirect.com/science/ar…
tl;dr: I describe one of my central beliefs – the importance of taking breaks from the lab to allow for creative scientific thought.
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I'm so honored to be elected a Fellow of the American Academy of Microbiology. Thank you so much to my amazing lab members, my fantastic mentors, and all you great role models. I am so lucky and thankful. Here's to our great community and to even more awesome science to come!
15 Feb 2024
Join us in congratulating the 65 new fellows elected to the American Academy of Microbiology! Fellows are elected annually through a selective, peer-review process based on their scientific achievements and original contributions. See the full list: asm.social/1Id
ALT Congratulations new Academy Fellows!
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4 Jan 2024
New year, new class of antibiotic - but the old model of reimbursement will kill it unless we change course.
A new class of antibiotics is cause for cautious celebration — but the economics must be fixed nature.com/articles/d41586-0…
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2 Nov 2023
Story time: when I started my postdoc with @WatersLabMSU in August last year, we aimed to use V. cholerae to understand how genetic interactions, including epistasis and pleiotropy, influences its pathogenesis and evolution. 1/18
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1 Nov 2023
I had such a blast talking with my old friend and former UCSF colleague @ctmurphy1 about her new book. Congratulations Coleen on this major accomplishment!
1 Nov 2023
“How Do We Age? The Science of Longevity” by @ctmurphy1 is the latest deep dive into the subject by a prominent biologist of aging. In this episode, Prof. Murphy shares her motivation for writing the book and her unique perspective on the field.
player.captivate.fm/episode/…
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20 Oct 2023
Why does Mycobacterium tuberculosis form cords? It's immediately apparent when viewing a bacterial culture growing without detergent under a microscope. Delighted to have led an interdisciplinary study to answer this puzzle (1/8)
authors.elsevier.com/sd/arti…
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Will post a longer thread soon but couldn't wait to share! Happy to chat with anyone about using M3-Seq for all your bacterial single cell sequencing needs! And thanks to our fearless @wang_batman for leading the charge and our amazing collaborators @bsadamson and Ned Wingreen.
31 Aug 2023
🔥hot off the press - a new single cell RNA sequencing approach in bacteria reveals rare populations and bet-hedging behaviours by @wang_batman @bsadamson @zgitai1 and Ned Wingreen
nature.com/articles/s41564-0…
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19 Jul 2023
Congratulations Sneha Rath *18, who earned her PhD in the lab of @PrincetonMolBio's Alexei Korennykh for her award winning essay about confronting an unanticipated ethical issue in research. Meet Snetha and the other winners here: laskerfoundation.org/2023-es…
ALT Sneha Rath *18, former graduate student in the lab of Alexei Korennykh. Photo from Dr. Rath's LinkedIn profile.
18 Jul 2023
Sneha Rath, winner of the 2023 #LaskerEssay Contest, talks about her favorite part of research. @MassGeneralNews @harvardmed @broadinstitute
Read her essay, published in @jclinicalinvest: ow.ly/oEBp50PfluS
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Congratulations, John!
14 Jun 2023
Congrats to #PrincetonU professor John Brooks, who has been named one of 22 new Pew Scholars in the Biomedical Sciences by @pewtrusts. 👏 bit.ly/43Rffzu
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I’m beyond delighted to share our first efforts in studying the skin microbiome. This work was championed by the amazing Ellie Acosta @BacteriaHunter, who deserves so much credit for her amazing persistence and insight. elifesciences.org/reviewed-p…
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This new perspective can help explain many open questions in skin microbiology like why there is so many DNA from anaerobes on the surface, how the microbiome can talk to immune cells, and why the skin microbiome appears stable over long timescales but unstable over short times.
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There is so much left to unravel, but this is such an exciting start. It’s also important to thank our fantastic collaborators, @donia_lab, Danelle Devenport, @bpbratton, Jaime Lopez, Katherine Little, Xuming Mao, and Aimee Payne. What a privilege to be part of this amazing team
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