#Keepmasksinhealthcare. PhD health services & public health Northwestern. Frmr: PennMedicine, VA, Harvard, MA HHS Alum:Columbia, Cornell. tweets: my own opinion

Joined March 2012
852 Photos and videos
This is great news!
🚨💊HUGE news: @US_FDA has finally granted approval to @ShionogiUS’s Xocova (Ensitrelvir), a 2nd-generation antiviral targeting SARS-CoV-2. The approval is for the indication of “post-exposure prophylaxis of COVID-19 following contact with an individual who has COVID-19”. However, just like with any drug, it can obviously also be used off-label (e.g. treatment of both acute COVID or Long COVID). In Japan, Xocova received Emergency Use Authorization for the treatment of acute COVID all the way back in November 2022, received full approval in March 2024, and an expansion to include post-exposure prophylaxis in March 2026. The post-exposure prophylaxis indications are based on the SCORPIO-PEP trial (nejm.org/doi/full/10.1056/NE…), where Xocova reduced the incidence of COVID-19 after household exposure by 67%, from 9.0% down to 2.9%. Mechanically, Xocova is the same class of drug as Paxlovid - a 3C-like protease inhibitor that inhibits viral replication. From our best understanding, Xocova is probably slightly more potent than Paxlovid, but the more definitive advantage is that it comes with less side effects and less drug interactions (which are caused by the Ritonavir component of Paxlovid, added to boost the concentration of the actual antiviral, Nirmatrelvir). Xocova should be useful for lowering viral load during an acute infection, especially if taken within a couple or days of symptom onset, which may help shorten the duration of acute symptoms. Will it do anything to prevent long-term damage or the development of Long COVID? Almost certainly not, just like Paxlovid, but I’d be more inclined to tell people that it’s worth trying if we’re no longer dealing with the side effect profile of Paxlovid. Where it makes the most sense to use Xocova, just like with Paxlovid, is as a component of polytherapy for Long COVID driven by viral persistence. The big issue there, however, is that you need a longer course of these antivirals than most physicians are willing to prescribe and/or most insurance companies are willing to cover. And they’re generally not very effective as a monotherapy, you need to pair these oral antivirals with other therapies for better coverage and tissue penetration (eg. monoclonal antibodies and Nuvaxovid, and potentially even a 2nd antiviral like Remdesivir). All in all, this is a very important and long overdue approval. It’s not a game-changing silver bullet, and notably, nobody should really be expecting to use or rely on Xocova in a way that they wouldn’t be open to using or relying on Paxlovid in the present. But there are plenty of applications for it, and Xocova should absolutely be seen as another Swiss cheese layer / tool in the toolbox for COVID conscious community members and any allied medical providers.
1
74
#LongCovid only ends when infections are stopped.
New JAMA Network Open study: 📊 Long COVID prevalence estimated at ~16% 🏥 58 U.S. hospitals 🤖 AI-based EHR phenotyping ⚠️ Diagnosis codes alone missed many cases The burden of #LongCOVID is likely much larger than initial data suggest. jamanetwork.com/journals/jam…
3
7
224
Pancreatic cancer is probably the most serious and deadly types of cancer. An effective treatment is needed!
There hasn't previously been a treatment vs pancreatic cancer this successful. Striking improved (a > doubling) survival results @NEJM and @ASCO today with daraxonrasib, which also became available via an FDA approved early access program and began shipping to physicians this week @RevMedicines nejm.org/doi/full/10.1056/NE…
2
172
Andrew, PhD, MPH, CPH retweeted
“Given that nearly everyone in the US is believed to have had COVID, the 16% rate extrapolated to the approximately 340 million people in the country would mean that roughly 54 million Americans developed #LongCovid. An HHS spokesperson did not respond to a request for comment.”
25
560
1,566
29,517
Andrew, PhD, MPH, CPH retweeted
As part of #WorldMaskWeek, this Thursday, May 28th, we'll co-host a free Zoom discussion with @AirSupportBox all about mask blocs: what they do, how they get masks and tests and other items to distribute, how you can find one near you, and how you can start one in your area.
2
31
59
3,244
A basic public health measure that should be celebrated during this weekend of memorial day honoring those whom have fallen
World Mask Week is here! #WorldMaskWeek is a global event for talking about masking, sharing pictures about masking, and helping those who may have stopped masking come back to it without shame or judgement.
3
44
Covid is low and may it keep lowering!
This is the People’s CDC bi-weekly update for May 4, 2026! This Weather Report from the People’s CDC sheds light on the ongoing COVID pandemic and other public health crises in the United States.
3
61
Andrew, PhD, MPH, CPH retweeted
Support our colleagues in Illinois to protect the right to mask by tomorrow, May 12th! Kiki's Law (SB3340) was passed in the IL senate and now it is under consideration by the IL House.
2
4
6
653
This is truly alarming. How many other people in medicine does this? many.
4
140
Andrew, PhD, MPH, CPH retweeted
May 11
CIDRAP Op-Ed: Why the FDA tried to bury studies showing vaccines are safe The COVID and shingles vaccine studies were suppressed because they showed the vaccine-safety system works. Full Op-Ed by @jakescottMD: ow.ly/7SxI50YXLaP 📷: Asian Development Bank / Flickr cc
2
31
41
2,153
This is why they needed immediate independent isolation measures. Don't lump them together at at part of the journey.
Earlier today I spoke with the doctor on the ship and he confirmed something. CDC messaging continues to say "prolonged, close contact" but that contradicts: 1) what's in the literature, and 2) what's happening on this ship. --> the doc told me a few who got infected/died DID have direct contact w/ very sick patient while treating them, but 3 who tested positive did NOT have direct physical or close contact - only shared time in a few spaces on the ship where people congregate (dining, lecture area)
2
100
This is why it must be done immediately and the current steps remain necessary!
Lesson from Covid… by the time you realize that you need mandatory quarantines and mass testing… it’s too late for those measures to be fully effective. Waiting until people become symptomatic to test/ isolate is a bandaid on a hemorrhage.
3
120
Andrew, PhD, MPH, CPH retweeted
Public health has a disinterest in "implementation science," how to help people DO what works, like masking well. When people note barriers (age, health, preference), we must not concede. Overcome barriers. Help people find well-fitting N95 respirators. x.com/disclosetv/status/2053…

NEW - WHO's Tedros responds to pictures that have been circulating online of one of the passengers not wearing a mask: "Many of these passengers are elderly and you can imagine how uncomfortable it could be when you have, especially FFP2 masks."
11
45
250
5,152
Andrew, PhD, MPH, CPH retweeted
And you don't even need to live in Illinois to do it! Anyone in the U.S. can "slip" in our favor! docs.google.com/document/u/2…

1
11
28
937
Andrew, PhD, MPH, CPH retweeted
Andes hantavirus has documented human-to-human transmission, yet current WHO guidance still does not recommend airborne precautions or respirator use (such as N95s). WHN has issued an open letter urging stronger protections for healthcare workers, passengers, and the public, including clearer guidance on airborne risk, respirator use, and prevention measures. Read the full open letter: whn.global/open-letter-to-wh… #Hantavirus #AndesHantavirus #PublicHealth #InfectionPrevention
21
190
349
8,967
Illinois and their residents support medical masking! Let's make this official and a protected law.
NATIONAL CALL-TO-ACTION—Help us enshrine the right to wear medical respirators in Illinois. Let's make sure this forward-thinking bill becomes first-in-the-nation law: fill out a proponent witness slip! And you don't need to live in IL to do it 🧵
2
6
63
This op ed is very clear. Air monitoring is an important step for safer indoor classrooms.
Replying to @michael_hoerger
Op ed calling for air quality monitors in every public classroom in Illinois. Full text: oakpark.com/2026/04/21/long-…
1
2
62
An incredibly important bill to protect kids in schools from infectious diseases! Vote in support by tomorrow!
💥BIG DAY TOMORROW💥 We have a Subject Matter Hearing in the IL Senate’s Appropriations-Education Committee for our school air quality bill (SB3110). To fill out a slip as a **PROPONENT** pls follow this link & see the images below for instructions. ilga.gov/Senate/hearings/det…
1
2
60