Today's @NobelPrize for John Hopfield recognizes only one of his contributions - he's a true polymath. I strongly recommend his solo author PNAS papers (i) long-range e- tunneling in proteins (1974), (ii) kinetic proof-reading (1974), (iii) Hopfield nets (1982). Each is a gem!
The phrase ‘metastasis accounts for 90% of cancer deaths’ is one of the most widely used in cancer research, yet it is overly simplistic & imprecise. Here we dig deeper into the events leading to cancer mortality
nature.com/articles/s41568-0… 1/2
In our latest pre-print @yifanrobinzhao, @gavinpaulkelly and @gantasperez reveal that mild hypoxia is a physiological consequence of growth in Drosophila imaginal discs.
Check the work in biorxiv.org/content/10.1101/…
Researchers at the Crick, working with @UCL and @ImperialCollegeLon, have discovered a new biological pathway that drives inflammatory bowel disease (IBD) and can be targeted using existing drugs.
crick.ac.uk/news-and-reports…
This is a blatant misrepresentation of our work science.org/doi/10.1126/scie…. Our study does not in any way suggest that the application of SPF50 sunscreen “blocks our natural defences” or is detrimental to health.
Vitamin D regulates cancer immunity via microbiome- another reason to stop using SPF 50 all year round which blocks our natural defences science.org/doi/10.1126/scie…
Community note
The linked study is a pre-clinical study based on mice alone. The suggestion that this means humans can reduce SPF use is not evidence-based, and should be read with caution.
science.org/doi/10.1126/sc…
Presenting metabolomics analyses: what is in a number? embopress.org/doi/full/10.10…@JohannesMeiser and I wrote this short piece to raise awareness about how present metabolomics data. We hope you will find it useful. Any comment is welcome! thanks @DanielKlimmeck for the support!
The proof just arrived this evening at my door. I am pleasantly surprised at the quality. The print version will be available in a few days at the royalty-free price (Amazon).
Still, feel free to download it in its entirety at
masspec.scripps.edu/about/ma…
or
doi.org/10.63025/LCUW3037
Less than two weeks left to apply for our postdoctoral career development fellowships for clinicians 👩⚕️
Learn more about this fully-funded postdoctoral research opportunity and apply by 30 April ⬇️
crick.ac.uk/careers-study/cl….
UMAP dimensionality reduction was designed to help visualize relationships in high-dimensional data. But, most users don’t know how it works, and therefore can’t usefully interpret the graphs.
This is a great UMAP description, with interactive sliders! pair-code.github.io/understa…
In a departure from biological rhythms, we’re excited to share our work describing the role of macromolecular assembly & condensation in the acute buffering of cellular water potential, published today @Nature. A thread: 1/16
nature.com/articles/s41586-0…
While most people have been trying to inhibit kinases, @CellsigL@uclcancer have made the first PI3K activator drug 🤯
‘A small-molecule PI3Kα activator for cardioprotection and neuroregeneration’ out now in @Naturenature.com/articles/s41586-0…