@BennyChain profile picture
Benny Chain @BennyChain

Immunologist at UCL

Joined March 2009
  • Tweets 656
  • Following 183
  • Followers 1,338
6 Photos and videos
Can now run the whole pipeline using a single command. Much faster and more memory efficeint.
Benny Chain@BennyChain
29 Aug 2024
For all the T cell receptor sequencers out there, the latest version of our analysis pipeline Decombinator 5.0 is live, and now on PiPy for greater ease of installtion ! Thanks to Matt Cowley for a huge amount of work ! pypi.org/project/decombinato…
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For all the T cell receptor sequencers out there, the latest version of our analysis pipeline Decombinator 5.0 is live, and now on PiPy for greater ease of installtion ! Thanks to Matt Cowley for a huge amount of work ! pypi.org/project/decombinato…

decombinator

A fast and efficient tool for the analysis of T-cell receptor repertoire sequences produced by deep sequencing.

pypi.org
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Benny Chain retweeted
The Francis Crick Institute@TheCrick
9 Jul 2024
We are delighted to announce that Professor Edith Heard has been appointed as our new director and chief executive! Edith, who is currently director-general at @EMBL, will succeed Paul Nurse in leading the Crick from the summer of 2025. 🔗 crick.ac.uk/news/2024-07-09_…
"The Francis Crick Institute has quickly established a global reputation for its work at the frontiers of science. I relish the challenge of building on that work. I also want to pay tribute to Sir Paul Nurse, without whom the Francis Crick Institute would not be the world-leading institution it is today." - Edith Heard

ALT "The Francis Crick Institute has quickly established a global reputation for its work at the frontiers of science. I relish the challenge of building on that work. I also want to pay tribute to Sir Paul Nurse, without whom the Francis Crick Institute would not be the world-leading institution it is today." - Edith Heard

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Single cell analysis of the phenotype of bonemarrow T cells in myeloma reveals striking phynotypic differences from solid tumour TILS. Read our latest paper out here medrxiv.org/content/10.1101/…

Tumour-intrinsic features shape T-cell differentiation through myeloma disease evolution

The haematological malignancy multiple myeloma is associated with skewed T-cell activation and function. T-cell alterations are detectable in asymptomatic myeloma precursor conditions and have the...

medrxiv.org
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Benny Chain retweeted
Weizmann Institute
@WeizmannScience
4 Jun 2024
Are you a PhD graduate in Physics, Chemistry, Earth Science, Math or Computer Science? Apply for the Max Planck-Weizmann Joint Postdoctoral Program. Includes a fully funded four-year position, split equally between these two esteemed institutions >> bit.ly/mpg_wis

Four-Year Postdoctoral Position at MPG-WIS

weizmann.ac.il
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Benny Chain retweeted
Christopher A. Baker@bakermind
19 Jun 2024
New major team preprint demonstrating antibodies from #longCOVID patients are sufficient to cause pathology and behavioral symptoms when transferred to mice. Importantly, they match individual patient symptoms to potential autoantigen targets and induced mouse behaviors
Prof. Akiko Iwasaki
@VirusesImmunity
19 Jun 2024
Sharing our new study by @keylas3, @SilvaJ_C, Rafael Bayarri Olmos et al (with T. Horvath & @PutrinoLab) showing that a passive transfer of IgG from patients with #longCOVID into mice recapitulates ⬆️ pain and other symptoms 🧵 (1/) medrxiv.org/content/10.1101/…
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Dr Vicky Enne 🇪🇺@Beat_AMR_Bugs
16 Jun 2024
Replying to @UCLInfectImm
👏👏👏 Fantastic, well done Paul. A great man.
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Mahdad Noursadeghi@mnoursad
7 Jun 2024
We're hiring! Are you a lab scientist interested in human immunology of infectious disease, using cellular models of host-pathogen interactions and human experimental challenge, focusing on immune responses in Tuberculosis and SARS-CoV-2? Apply here: bit.ly/3yPdfO5
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The latest exciting step forward in T cell receptor representation ! @YutaNotUtah outperforms TCR-BERT ! arxiv.org/pdf/2406.06397
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We are looking for a research fellow interested in the T cell receptor repertoire to work on some amazing cancer data sets. Check out this job at UCL: linkedin.com/jobs/view/39304…
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Benny Chain retweeted
Andreas Tiffeau-Mayer@andimscience
30 May 2024
How do interactions between hypervariable loops shape TCR specificity? Can patterns of sequence co-variation help us pair alpha-beta chains using techniques developed for co-evolving proteins? New work led by @Martina_Milig now out on bioRxiv! 👇
Martina Milighetti@Martina_Milig
29 May 2024
New preprint! We investigated the molecular interactions between the TCR CDR loops and find that these may be important in shaping TCR specificity and sequence biorxiv.org/content/10.1101/…
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Martina's elegant new paper defines an important and under-appreciated role for molecular interactions between CDR loops of the TCR !
bioRxiv Immunology@biorxiv_immuno
29 May 2024
Intra- and inter-chain contacts determine TCR specificity: applying protein co-evolution methods to TCRαβ pairing biorxiv.org/cgi/content/shor… #biorxiv_immuno
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Benny Chain retweeted
Nature Microbiology@NatureMicrobiol
9 Apr 2024
OUT NOW 📢: A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting @zgitai1 nature.com/articles/s41564-0…

A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum...

Nature Microbiology - The dihydrofolate reductase inhibitor, fluorofolin, shows potent activity against Pseudomonas aeruginosa and selectively eliminates P. aeruginosa from mixed-species bacterial...

nature.com
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Benny Chain retweeted
zgitai@zgitai1
10 Apr 2024
So excited for our latest story on a tunable-spectrum antibiotic to be published. We desperately need microbiome-sparing strategies to treat P. aeruginosa. Amazing effort led by the fantastic @ConnorChain
Nature Microbiology@NatureMicrobiol
9 Apr 2024
OUT NOW 📢: A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting @zgitai1 nature.com/articles/s41564-0…
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Andreas Tiffeau-Mayer@andimscience
18 Mar 2024
Lightning-fast adaptive immune receptor similarity search by symmetric deletion lookup arxiv.org/abs/2403.09010 In work led by @heartnetkung we show how an algorithmic paradigm from spell checking can accelerate TCR clustering by orders of magnitude

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Andreas Tiffeau-Mayer@andimscience
11 Jan 2024
Three weeks left to apply to our open-rank search in AI & Infection! Come join us at @UCLInfectImm 😀
Rob Heyderman@RHeyderman
6 Dec 2023
Group Leader in Infection & Artificial Inteligence @UCLInfectImm New post to strengthen AI & computational approaches to Infection Biology. Linking with world-class expertise @UCL bioscience, population sciences, computer science & structural biology tinyurl.com/3mpsu7pk
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Benny Chain retweeted
Quezada Lab@QuezadaLab
10 Jan 2024
The Arthur and Sandra Irving Cancer Immunology Symposium Website: irvingcancerimmunologysympos… Hosted by Arthur and Sandra Irving symposium (from Jun 24-27, 2024 in Boston) will focus on advancing the careers of young scientists doing research in cancer immunology. Apply!!!

Home

Bringing the brightest minds together

irvingcancerimmunologysymposium.com
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Benny Chain retweeted
Andreas Tiffeau-Mayer@andimscience
12 Dec 2023
Glad to announce that our QImmuno lab approach for TCR-pMHC specificity prediction just won silver and bronze medals in the IMMREP23 benchmark! 🥳 kaggle.com/competitions/tcr-…

IMMREP23: TCR Specificity Prediction Challenge

Competitors will make predictions on previously unpublished TCR-epitope binding data in order to benchmark prediction methods.

kaggle.com
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This seems a cool paper - proteins in the shapes of letters or digits !! nature.com/articles/s41586-0…
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Benny Chain retweeted
Renato Ostuni@OstuniLab
1 Nov 2023
💥BIG PAPER ALERT💥 So excited to share our latest, out now @Nature! Here, we uncover a spatially confined interplay between subsets of IL-1b macrophages and tumor cells that fuels pathogenic inflammation in pancreatic cancer (1/n) nature.com/articles/s41586-0…

IL-1β macrophages fuel pathogenic inflammation in pancreatic cancer

Nature - Single-cell and spatial gene expression analyses of pancreatic ductal adenocarcinoma uncover a population of interleukin-1β-expressing macrophages that drive inflammatory...

nature.com
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