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Our first 2021 paper reveals the prevalence and mechanism of a co-translational protein assembly mechanism in human cells: co-co assembly.
Congratulations to the co-co team @KaiFenzl, @matildebertolin and @guenter_kramer!
science.sciencemag.org/conte…
@Sciart by @munafomarzia
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Bukau Lab retweeted
5 Feb 2023
What shall Germany deliver next? A good question posed by @faznet, thanks 🙏🏻 Well, the answer is obvious:
Ukraine desperately needs 🇩🇪 fighter jets Tornados & Eurofighters💪
Dear German Government, please do not hesitate
Just do the right thing!
m.faz.net/aktuell/politik/au…
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Great news! Together with @sjtans & @The_Ban_Lab, we are among this year's recipients of a Synergy Grant from @ERC_Research. This marks the beginning of an exciting journey into a mechanistic analysis of the biogenesis of protein complexes 🧬
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Hier eine schöne Allegorie wie das von @LabJoazeiro und @PfefferCryoLab beschriebene MutS2 Protein fehlerhafte Proteinbiosynthese anhand kollidierter Ribosome erkennt und verschiedene Qualitätskontrollmechanismen initiiert bevor das fehlerhafte Protein der Zelle schaden kann.
10 Mar 2022
Auffahrunfall auf der „Ribosomen-Autobahn“: Wissenschaftler identifizieren bakterielles Protein, das „stehengebliebene“ Ribosomen erkennt und rettet
@ZmbhH
uni-heidelberg.de/de/newsroo…
ALT Deutsch: Kryo-EM-Struktur der kollidierten Ribosomen mit MutS2. Die verschiedenen molekularen Bestandteile wurden unterschiedlich eingefärbt (stehengebliebenes Ribosom: orange; kollidiertes Ribosom: grün; MutS2: blau; mRNA: pink). Bild: Sebastian Filbeck (ZMBH)
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Bukau Lab retweeted
9 Mar 2022
How do cells fire up the #RQC engine? Check out our structural and mechanistic blueprint for bacterial #ribosome collision sensing by MutS2, out today in @Nature. MutS2 senses collisions and splits ribosomes to initiate RQC!
nature.com/articles/s41586-0…
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B. subtilis MutS2/RqcU deals with stalled ribosomes by binding collided disomes, recruits the RNA degradosome and initiates #RQC by #ribosome splitting. Happy we could contribute to this work led by @LabJoazeiro in collaboration with @PfefferCryoLab x.com/ZmbhH/status/150159148…
A team of researchers led by ZMBH's PIs C. Joazeiro @LabJoazeiro and S. Pfeffer @PfefferCryoLab discovered how the bacterial MutS2 protein prevents damage by stalled ribosomes! Further details in Nature nature.com/articles/s41586-0…
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Bukau Lab retweeted
A new study by the @bukaulab in @CellReports sheds light on role of Nt acetylation in eukaryotes cell.com/cell-reports/fullte…
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Bukau Lab retweeted
Comparative SUMO proteome analysis identifies novel SUMO-controlled regulators in EGFR signaling - paper by a team led by @frauke_melchior embopress.org/doi/full/10.15…
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Our first 2021 paper reveals the prevalence and mechanism of a co-translational protein assembly mechanism in human cells: co-co assembly.
Congratulations to the co-co team @KaiFenzl, @matildebertolin and @guenter_kramer!
science.sciencemag.org/conte…
@Sciart by @munafomarzia
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Congratulations to our colleagues @ZmbhH for the great work!!
30 Nov 2020
How do you synthesize proteins with only half a ribosome? We are excited to share our work on the structural basis of Alanine tailing in bacterial ribosome-associated quality control (RQC). Great collaboration with @LabJoazeiro @ZmbhH.
cell.com/molecular-cell/full…
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Bukau Lab retweeted
22 Nov 2020
PNAS selected our joint work with @BukauLab on the mechanism of fiber disaggregation to be highlighted on their journal club blog! @PNASNews
blog.pnas.org/2020/11/insigh…
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Bukau Lab retweeted
11 Nov 2020
Read our new article in @nature! Congratulations to Ofrah, Meital and Michael! It was fun working with @BukauLab @london_lab, here's to many more! 🥂
nature.com/articles/s41586-0…
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And that makes two: The fruits of a fun and productive collaboration with the @lab_rosenzweig on a unique regulatory mechanism of class B JDPs that is essential to DNAJB1s ability to support amyloid disaggregation by HSP70.
nature.com/articles/s41586-0…
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Excited to share our latest work on the mechanism of amyloid disaggregation by the HSP70 chaperone machinery, now published in @nature. Thanks go to @NadinathN, Janosch Hennig, @PaoloDeLosRios and Alessandro Barducci.
nature.com/articles/s41586-0…
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Hermann Bujard (1934 – 2020) – pioneering researcher and visionary science politician | The EMBO Journal embopress.org/doi/full/10.15…
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