💙E3 Ubiquitin ligases and Protein Quality Control: mechanisms, functions and relevance for aging-related diseases, in particular neurodegeneration
Joined May 2019
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9 Mar 2022
The Mother of All Ribosome Collisions
Life before #ubiquitin: B. subtilis MutS2/RqcU senses translational stalls that lead to #ribosome collisions, then elicits degradation of the incomplete nascent-chains. Excited to share our findings, online @Nature today.
#RQC
A team of researchers led by ZMBH's PIs C. Joazeiro @LabJoazeiro and S. Pfeffer @PfefferCryoLab discovered how the bacterial MutS2 protein prevents damage by stalled ribosomes! Further details in Nature nature.com/articles/s41586-0…
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10 Dec 2025
A Tenure Track Professorship at the ZMBH in Heidelberg, Germany, has just been advertised, (18 January 2026 deadline)
nature.com/naturecareers/job…
I encourage excellent candidates in the broad #proteostasis and/or translation fields to apply! @scijobs @sciencejobs_eu
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20 Jun 2025
With this new funding, we’re hiring PhDs and #postdocjobs
Our #ERCAdG studies on the role of #RQC #ribosome #ubiquitin in #neurodegeneration will include using iPSCs, i-neurons, mammalian TC. The lab also has ongoing projects on #mitochondria and bacterial RQC.
20 Jun 2025
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20 Jun 2025
Thrilled and honored to receive the #ERCAdG! This will fund us for the next 5 yrs for groundbreaking research
My project SuTra focuses on the Surveillance of Translation, from sensing #ribosome stalling to #RQC. We aim to learn how defective surveillance causes neurodegeneration
17 Jun 2025
📣 Good news: 281 top researchers have just won ERC Advanced Grants!
The new funding, worth nearly €721 million, is part of the 🇪🇺 EU’s #HorizonEurope programme.
Read more 👉 europa.eu/!JYKxkD
#ERCAdG #FrontierResearch @EUScienceInnov
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17 Jun 2025
Thanks, Ino! Thanks also to the LS1 panel for a constructive, fun interview! And congratulations to all fellow awardees! #ribosome #RQC #ubiquitin x.com/inoagrafioti/status/19…
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2 Oct 2024
Thanks for your many contributions, Ivan. And of course, we would not have known about this amazing venue had you not pioneered meetings here.
30 Sep 2024
Impressive #EMBOubiquitin24 in #Cavtat with more than 300 participants & active discussions at posters. Superb success- thx to the organisers @MerblYifat76992, @YKulathu, @LabJoazeiro, @polosimona1, @EMBOevents 🙌👏🫶👍
The hotel and weather matched the quality of science 😊
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2 Oct 2024
Thanks, Shalini. Your talk was awesome!
1 Oct 2024
Grateful to connect and learn from the great minds in ubiquitin, proteostasis and organelle quality control! Such a well-organised event! #EMBOubiquitin2024
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23 Sep 2024
Congratulations to my stellar (ex) PhD student Federico and all the awardees and honorable mentions for this achievement!
23 Sep 2024
honourable mentions: Christian Baca from @RockefellerUniv, Federico Cerullo from ZMBH Heidelberg (@UniHeidelberg), Pascal Devant from @Harvard, Leonard Ernst from @mpi_marburg @maxplanckpress 9/
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23 Sep 2024
Federico followed up on our discovery that bacteria also have an RQC pathway. In collab w @PfefferCryoLab, he elucidated mechanisms underlying Ala-tailing by RqcH (the homolog of Rqc2/NEMF), and discovered a factor that senses collided ribosomes upstream of RQC (hence, RqcU).
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23 Sep 2024
The credit to brilliant and fun thesis defense poster goes to Giuliano Arcaio
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Joazeiro Lab retweeted
19 Jun 2024
Don’t miss our next free virtual networking events in July! Will be fantastic ☺️
19 Jun 2024
Excited to announce our upcoming free virtual Networking events on 16th of July, 2024 with special guests joining for a fireside chat! This is a great opportunity to hear from and interact with trailblazers in the field and then network in smaller groups. Links below to sign-up
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Joazeiro Lab retweeted
12 Jul 2023
Bacteria can counter noncanonical lipid ubiquitination with a #ubiquitin esterase! Fantastic collaboration with @ThurstonLab and @CMBI_Szczesna, with @r_lacoursiere driving our side of the project using some amazing tools built by the Geurink lab.
12 Jul 2023
Excited to share our preprint on how a cytosolic bacteria evades LPS ubiquitylation and antibacterial autophagy through an effector with esterase activity. Led by @CMBI_Szczesna in the lab @ImperialInfect @CBRB_Imperial with superb collaborator @jnpruneda researchsquare.com/article/r…
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27 Mar 2024
#CryoEM staff scientist position with awesome PI, doing exciting research, in great place. Apply! 🇨🇭🇨🇭🇨🇭
🔬 Join us at EPFL's School of Life Sciences as a Staff Scientist Expert in Cryo-EM! Work with cutting-edge facilities, collaborate with top researchers, and drive groundbreaking discoveries in structural biology. Apply now: ch.indeed.com/viewjob?jk=b45… #ScienceJobs #CryoEM #EPFL
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Joazeiro Lab retweeted
19 Dec 2023
Check out our new preprint: researchsquare.com/article/r…
A fantastic team effort, thanks to Jonas Duering Madita Wolter, and our spectacular collaborators. Massive thanks to all the people involved in this work!
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Joazeiro Lab retweeted
12 Dec 2023
Excited to share the final product of this work, now available at @MolecularCell. Extremely proud of @tylergfranklin for this and many other achievements during his thesis work!
sciencedirect.com/science/ar…
6 Jun 2023
What can bacteria teach us about #ubiquitin? A lot!
In our latest preprint, @tylergfranklin set out to understand how secreted bacterial ligases catalyze ubiquitin modifications during infection. What he found will surprise you!
biorxiv.org/content/10.1101/…
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12 Nov 2023
re-tweeting announcement with fixed typo
11 Nov 2023
With a fixed typo, I re-invite you to come chat Ub & Targeted Protein Degradation with our welcoming community at the @FASEBorg #UBPSRC where full days of exciting science with joyful interactions will be capped by nightly fireworks over the natural wonder of Niagara Falls.
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9 Nov 2023
We're excited with our line up of speakers for the FASEB #Ubiquitin meeting in June 2024! Join us in Niagara Falls to hear stories ranging from ubiquitin signaling and mechanisms to #RQC and targeted protein degradation (#TPD #protacs #molecularglues)
9 Nov 2023
Please join us this summer as the power of Ubiquitin Signaling converges with the power of Niagara Falls for @FASEBorg #UBPSRC. We value DEIA, are raising $ for travel awards, have fantastic speakers and are excited to select new speakers from abstracts. @LabJoazeiro
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Joazeiro Lab retweeted
2 Oct 2023
New work from the lab @NatureAging! 🌱🌱 We asked whether the ability of plants to suppress pathological protein aggregation can be applied into human cell and animal models to delay or even prevent neurodegenerative diseases
nature.com/articles/s43587-0…
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