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Craig E Brown @CraigEdBrown

Professor at UVic. interested in neuroscience, micro-circulation, hockey. Lab website: brownlabatuvic.com

Joined January 2018
  • Tweets 786
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  • Followers 696
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New finding from the lab. This surprised us since it went against the common assumption that increasing peri-infarct blood flow is best for stroke recovery. Congrats to Kamal and the team!  biorxiv.org/content/10.1101/…

Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow...

Focal stroke leads to complex changes in the cerebral microcirculation in surviving brain tissues that strongly influence recovery. Plasminogen activator inhibitor-1 (PAI-1; encoded by Serpine1 ) is...

biorxiv.org
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peterattiamd.com/link Nice write up on our paper by @PeterAttiaMD

Inflammatory molecule found in the blood may underlie the link between diabetes and dementia

A study in mice identified the cytokine IL-10 as a key culprit in diabetes-associated vascular damage in the brain and cognitive deficits

peterattiamd.com
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Was a pleasure to contribute a little to this new work from Tuan Trang and Yuta Kohro molecularbrain.biomedcentral…

Repeated naloxone-induced morphine withdrawal alters blood brain barrier and blood spinal cord...

Molecular Brain - Passage of molecules across the central nervous system is tightly regulated by the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB), which restrict entry of many...

link.springer.com
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Happy to share new paper from MSc grads Myrthe and Jenna. We asked the question, when part of the brain dies during stroke, what happens to local and distant cortical neurons that innervate the stroke site (in S1 cortex) or those that receive outputs? journals.sagepub.com/doi/10.…

Retrograde and anterograde trans-synaptic viral tracing of neuronal connections reveals local and...

Focal stroke leads to complex neurological disturbances with variable recovery. One explanation for this variability is that stroke disrupts local and remote ne...

journals.sagepub.com
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Main findings: 1) dendritic spines in peri-infarct and ipsi motor cortex most disrupted by stroke but generally recover by 6 wks, 2) ipsi S2 and contra-lateral S1 show minimal changes despite extensive connections, 3) neurons innervating stroke site survive just fine (supp fig).
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The pathobiology of neurovascular aging: Neuron cell.com/neuron/abstract/S08…

The pathobiology of neurovascular aging

As the population ages, neurovascular pathologies have become leading causes of death and disability. Santisteban and Iadecola review data showing that neurovascular aging not only reduces cerebral...

cell.com
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Craig E Brown retweeted
Ruslan Rust
@rust_ruslan
6 Jan 2025
Endothelial Response to Blood-Brain Barrier Disruption in the Human Brain | JCI Insight insight.jci.org/articles/vie…
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Craig E Brown retweeted
The Sapieha Lab@psapieha
19 Dec 2024
Happy to share our study on the beneficial role of the innate immune system on vascular remodeling in retinal disease and potential negative impact of steroids. @MasayukiHata7 @UMontreal @ARVOinfo @CIHR_IRSC @_BrightFocus @AmDiabetesAssn @iserworld pnas.org/doi/10.1073/pnas.24…
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RT @MichelleRempel: That Trudeau would expect @cafreeland to deliver the FES after telling her ON FRIDAY he was firing her is peak chauvini…
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Rui Benedito@RuiBenedito_
13 Dec 2024
iFlpMosaics are now published @naturemethods. A compendium of novel genetic tools and related methods for inducing and analysing genetic mosaics in a high-throughput manner. nature.com/articles/s41592-0… Tweetorial 👇
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Gan Lab@LiGanLab
2 Dec 2024
Excited to share our work, new in @ScienceMagazine: science.org/doi/10.1126/scie…. We explored how sex chromosomes, gonadal hormones, and their interaction shape cellular responses in aging and #Alzheimers mouse models. This led to key insights on Tlr7 and neurodegeneration 🧵(1/5)

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Replying to @WestJet
@westjet screwed us on our Europe trip. Of course no one is surprised by this. Canadians have few travel options and are forced to put up with this crap. Its especially bad for small city travellers that always have to make a connection vancouver.citynews.ca/2023/0…

Air Canada, WestJet flight delay data - CityNews Vancouver

An aviation data firm shows Canada's two biggest airlines see a higher proportion of flights delayed compared with many peers abroad.

vancouver.citynews.ca
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Happy update. In response to losing a day of holiday and 1 night hotel in Paris, @WestJet offered us a $15 food voucher. They really do care!!
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Nature Reviews Endocrinology@NatureRevEndo
28 Nov 2024
The epidemiology of type 1 diabetes mellitus in older adults go.nature.com/4hR0q8e #diabetes #T1DM #T1D
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Congrats to the team! Here we directly image and quantify cerebral #angiogenesis and pruning in vivo. Found interesting regional differences and dependence on #notch signalling. Where you look does matter! cell.com/cell-reports/fullte…

Angiogenesis in the mature mouse cortex is governed in a regional- and Notch1-dependent manner

The angiogenic capacity of the mature healthy brain and its underlying mechanisms are unclear. Raudales et al. show that rates of cerebral angiogenesis follow regional gradients and are regulated by...

cell.com
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Come join us! can-acn.org/research-assista…
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Michael Williamson@m_r_williamson
12 Nov 2024
Excited to share our new work out in @Nature ! Learning-Associated Astrocyte Ensembles Regulate Memory Recall nature.com/articles/s41586-0…

Learning-associated astrocyte ensembles regulate memory recall

Nature - A study in mice shows that learning induces c-Fos expression in a subset of astrocytes in the hippocampus, and that ensembles of these learning-associated astrocytes are involved in the...

nature.com
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Pleased to share our new paper implicating #interleukin 10 in perturbed #brain #microcirculation and #cognitiveimpairment in mouse model of type 1 diabetes. Congrats to the team @uvic, @sharmasorabh88, @UVicMedSciences, @NatMetabolism, nature.com/articles/s42255-0…

A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type 1...

Nature Metabolism - Interleukin-10 promotes the formation of microcirculatory defects in the brain associated with cognitive impairment in a mouse model of type 1 diabetes.

nature.com
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Craig E Brown retweeted
Eric Topol
@EricTopol
4 Nov 2024
In diabetes, the capillary microvessels can become obstructed, leading to damage to neurons and cognitive deficits. A new mechanism elucidated involving interleukin-10 may help explain why @NatMetabolism nature.com/articles/s42255-0… @CraigEdBrown @MyUVic nature.com/articles/s42255-0… @celineriera
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Osama Harraz@OsamaHarraz
8 Oct 2024
📰Excited to share our latest work just published in @NatureComms Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow nature.com/articles/s41467-0… 🧵
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