Cancer Immunometabolism - Professor - Director: Tumor Microenvironment Center - @PittTweet @UPMCHillmanCC - CoFounder:Novasenta - EiC:Immunology - views my own
Joined June 2017
- Tweets 2,179
- Following 394
- Followers 7,033
- Likes 13,011
261 Photos and videos
Pinned Tweet
Apr 29
Dearest gentle reader, we are delighted to announce a new story from our lab published in @Nature describing how a meal's systemic metabolic changes are interpreted by your immune system to enhance adaptive immunity. A thread 1/ nature.com/articles/s41586-0…
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Jun 11
PSA that Donald Trump’s 60 million dollar birthday party could fund ~20 labs research labs for 5 years with full indirects. Yet they’re telling us we have to cap and redistribute funds to everyone.
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Jun 7
This is literally the foundation on which I built my lab. Be a good advisor and recruit and foster excited scientists. Success becomes essentially a byproduct of a scientific culture that you maintain.
Jun 7
A PhD's success depends more on the fit between the student, the advisor, and the lab than on the specific topic being studied (it barely matters at all).
Similarly, a lab's success depends more on how excited (or miserable) its researchers are than on the precise project they are working on (it could be virtually anything).
This information isn't in papers or in grant proposals, you have to ask the researchers.
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Delgoffe Lab retweeted
One can only imagine how many of this we would have if the NIH budget were to be doubled or tripled. And how many more lives-would be saved. Something totally doable.
Cheers, chills, and a standing ovation when RASolute 302 showed unprecedented survival on daraxonrasib for patients with progressive pancreatic cancer
Seldom do you sense you’re witnessing a historic moment in cancer care but this feels like ras targeting has arrived
#ASCO26
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May 27
Amazing work from the @airdlab showing the importance of aKG for histone acetylation, rather than its more canonical role as a TCA cycle intermediate and cofactor for demethylation reactions! Kudos to all the authors!
May 27
It's time to rewrite reviews-aKG doesn't just regulate demethylation. Work from my lab and @mzspectrum demonstrates a new role for aKG in promoting histone acetylation and DNA repair through regulating carnitine synthesis. Congrats @ApoorvaUboveja!
nature.com/articles/s41586-0…
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Delgoffe Lab retweeted
"An army marches on its stomach" is true of the immune system, says @DelgoffeLab on @CBCQuirks, speaking about his and @DrAlok_np40's new @Nature study that found a single meal primes T cells to better fight infection and respond to cancer immunotherapy. cbc.ca/listen/live-radio/1-5…
ALT Screenshot of Quirks and Quarks podcast episode synopsis: You may have heard the old adage “starve a fever, feed a cold.” But following that advice might not put you on the best path towards a speedy recovery. Recent experiments in both humans and mice have found that the immune system gets a measurable boost from food. Eating a balanced meal nudges a type of white blood cell called a T cell to jump into action more quickly, which can help the body detect and stave off infections – and even fight some cancers. Greg Delgoffe, an immunologist at the University of Pittsburgh and UPMC Hillman Cancer Center, was a senior author on the study, which was published in Nature.
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May 21
Retatrutide phase 3 obesity trial just came out and the results are genuinely insane:
- 28.3% bodyweight lost on 12mg over 80 weeks
- 70.3 pounds on avg. or 31.9 kg
- 45.3% of patients hit 30% weight loss (this is bariatric surgery territory)
- 30.3% weight loss (85 lbs) at 104 weeks in higher-BMI patients
- 65.3% of 12mg patients dropped below the obesity BMI threshold
- 19% loss on 4mg over 80 weeks (47.2 lbs) with fewer dropouts than placebo (4.1% vs 4.9%)
- significant drops in blood pressure, triglycerides, non-HDL cholesterol, waist circumference, and hsCRP
- no cardiac or liver signals
Retatrutide is going to completely overshadow tirzepatide and semaglutide, and take the throne as the best-selling drug of all time.
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Delgoffe Lab retweeted
Love seeing our grantees in action! 🔬
This week, @Becky_ABC caught up with Greg Delgoffe & Tullia Bruno at the University of Pittsburgh, chatted with early-career researchers, and toured Pitt’s new biomed research hub.
Thanks for the great visit, @UPMCHillmanCC @PittTweet!
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Delgoffe Lab retweeted
May 20
In this @nature study, researchers in the @DelgoffeLab at @PittTweet showed that the short-term nutritional state of an individual has marked effects on T cell #immunity. 🍎
Read more: go.nature.com/4efI3KF
Tune into the discussion: bit.ly/3PCHwIK
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May 13
As you may know, every year @OveracreLab and I ride tandem to raise money for cancer research at @UPMCHillmanCC. Imagine the power if all my followers even donated a few bucks! 100% of your deductible donation goes straight to research!
haku.ly/f2a012d52c via @R2C_Cancer
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May 13
So honored and excited to talk about our new study, published in @Nature, on the BBC! @bbcworldservice
bbc.co.uk/programmes/w3ct8k2…
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May 11
#researcherspotlight Dr. Alok Kumar @DrAlok_np40 from Prof. Greg M Delgoffe lab @DelgoffeLab at University of Pittsburgh @PittTweet talks about his work on "How Eating Affects Immunity: Post-Meal Lipids Boost T Cell Function and Cancer Therapy" @Nature biopatrika.com/academia/rese…
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May 8
They did the meme!!!
NEW: MAGA evangelical leaders gather in Mar-a-Lago to bless and dedicate a gold statue dedicate to Donald Trump.
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May 7
While we can't go wrong with either choice in the @sitcancer election, I want to highlight the leadership and vision of @RobertFerrisMD. A dedicated surgeon and cancer immunologist, Bob's contributions to the field are immense; we'd be lucky to have him at the helm of SITC.
Thank you @sitcancer for the opportunity to participate in this election process, and to help contribute to the future of this amazing society! @UNC_Lineberger
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May 5
Thanks to @smithsonianmag for highlighting our work in @Nature about postprandial control of immunity! smithsonianmag.com/smart-new…
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Nature research paper: Postprandial lipid metabolism durably enhances T cell immunity
go.nature.com/3QQ4SuD
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Apr 30
The world is full of odd happenstances. On the same day our paper on postprandial metabolism dropped @Nature, my 1st grad student, Nicole, published her postdoc paper at @CellCellPress! An incredible tour de force studying proteostasis in T cell exhaustion cell.com/cell/fulltext/S0092…
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Delgoffe Lab retweeted
Apr 30
Can diet shape immunity? At University of Pittsburgh, Greg Delgoffe and team show T cells respond better after meals, likely boosted by higher protein production for faster activation. The experiment may pave way for better CAR T-cell therapy as engineered T-cells fight much effectively. nature.com/articles/d41586-0…
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Apr 29
Thanks for the highlight and your support of the Delgoffe Lab!
Starve a fever, feed a cold? According to new research from Emerging Leader Award winner Greg Delgoffe (@DelgoffeLab), there might be something to the old adage. In @Nature, Delgoffe shows that T cells are most effective shortly after a meal.
nature.com/articles/d41586-0…
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Apr 29
Thanks to @sciam for highlighting our new @Nature paper in a Breaking News article!
scientificamerican.com/artic…
(also now I want a burger)
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