Very happy to tweet about the most recent publication from @DileepVarmaLab @NU_CDB. Spindle microtubule-binding proteins including the Ska1 complex and the DNA replication licensing factor, Cdt1, enable the kinetochore-localized Ndc80 complex to form robust....1/n

I feel like crap. I didn’t get any grants this year, so I had to let go of my super talented postdoc—someone with a doctorate who’s now unemployed, without benefits or retirement, and still grinding away on a paper... Postdocs are the most unappreciated and undervalued positions at the PhD level-highly qualified, yet paid less than industry techs in Boston (with a BS degree) , forced to work weekends without benefits or job security, and at risk of losing everything if a grant isn't funded. Name another PhD role that's treated with less respect and value by the system.

A scientist from UNC Chapel Hill is running for congress in NC for a seat currently held by a republican. If you care about science (and democracy) please consider donating to his campaign secure.actblue.com/donate/pa…

Today @AnthropicAI released PubMed integration for Claude. No hallucinations. Just real science, real data. As a beta tester, this has been a game changer—like having a supercharged research assistant. Here are 6 prompts that will transform how you search the literature. A 🧵

Carlos Alcaraz defeats Jannik Sinner to reclaim the US Open title and the world No.1 ranking‼️

Researchers have developed a #DeepLearning system called BioEmu that rapidly generates diverse protein conformations, enabling fast, accurate insights into protein flexibility and function. Learn more this week in Science: scim.ag/41rCpxZ

I responded to the NIH request for information on the cap for publishing costs. The deadline is Sept 15. In short, my view is that NIH should cap journal publishing costs at $0. Journals delay science for months if not years, obscure peer review such that much reviewer effort is wasted, and create false certainty through their opaque gatekeeping. They've long devolved into career currency rather than tools for advancing science. Public funds should directly support robust public infrastructure: preprint servers, data repositories, automated solutions that reduce costs, and tools to facilitate interoperability/discoverability/reuse --not outdated publishing models that hold back progress. We need robust author-driven dissemination, transparent discussion, and solutions leveraging new technologies that improve utility of science -- not more subsidies for hopelessly broken systems. The NIH should fund a better future that taxpayers deserve

🏆😘 #Wimbledon

CARLOS II, PRINCE OF CLAY 👑 #RolandGarros

The @LurieCancer (LCC) went thru competing renewal of NCI designation. For a 2nd time we got "exceptional" ranking. The NCI site visit team gave a "perfect exceptional" (equivalent to 10). LCC is one of few in the nation and the only one in IL to ever achieve exceptional status.

Postdoc opening in Bidone Lab – start ASAP! Expertise in all-atom MD & enhanced sampling (steered MD, metadynamics, aMD, GaMD, REMD, etc.) required. 4 first-author papers in molecular modeling required. 2-yr project on PECAM1/PLXND1. Send CV 2 refs to apply. DM for info!

Your Action Is Needed! Congress needs to hear from scientists. Call your representatives to oppose funding freezes and restrictions on research. Find contact info at govtrack.us and make your voice heard today! #SciencePolicy ascb.org/science-policy/your…

My heart is broken as I announce the passing of my beloved husband, science partner and friend, Michael Sheetz. A remarkable scientist we packed 40 years of living into 20. Rejuvenation of senescent cells and mice in Press in Aging Cell; his last words were this was his best work

#CYTOSKELETON 2024 metrics are in. PUBLISHED ARTICLES are up 90% over 2023. Up 383% over 2022. Thanks for all of your support! Stay tuned for more metrics this week! #cell #cellbiology #research #publication (background is from vecteezy.com)

When you’re a grad student (at least back in the day), the conventional wisdom was to change your research direction or organism as a postdoc — to ensure you got some educational value out of the next stage. One of the main reasons I chose the postdoc lab I did was because when I visited, the students/postdocs were using so many different model systems… whatever best suited their research question. There were almost as many organisms in use as there were people in the lab. I found it such a refreshing approach. What if everyone could do this with even more accuracy to identify the most effective model systems for human-relevant insights? Smash cut to 15 years later. Check out our data-driven approach for choosing the best research organism for your favorite genes of interest. Check out the organism selection pipeline from @ArcadiaScience: The concept: research.arcadiascience.com/… The approach/analysis: research.arcadiascience.com/… The validation: research.arcadiascience.com/…

How did microtubules adapt to support life across 🐸species at divergent thermal niches? Now online & OA @CurrentBiology Thanks to @elladegaulejac @luca_troman @bis_was_here @CarolynMoores1 @mpiib_berlin @BirkbeckUoL 🙌 Enjoy reading! 👉 cell.com/current-biology/ful…

AT LONG LAST… The essential #adherensjunction mechanosensitive protein alpha-catenin is required for #cytokinesis fidelity. We credential a previously defined (but poorly understood) abscission factor in this process, LZTS2. 🧵1/12 rupress.org/jcb/article-abst…

Drawing in 3D

Vamos, @RafaelNadal!   As you get ready to graduate from tennis, I’ve got a few things to share before I maybe get emotional.   Let’s start with the obvious: you beat me—a lot. More than I managed to beat you. You challenged me in ways no one else could. On clay, it felt like I was stepping into your backyard, and you made me work harder than I ever thought I could just to hold my ground. You made me reimagine my game—even going so far as to change the size of my racquet head, hoping for any edge.   I’m not a very superstitious person, but you took it to the next level. Your whole process. All those rituals. Assembling your water bottles like toy soldiers in formation, fixing your hair, adjusting your underwear... All of it with the highest intensity. Secretly, I kind of loved the whole thing. Because it was so unique—it was so you.   And you know what, Rafa, you made me enjoy the game even more.    OK, maybe not at first. After the 2004 Australian Open, I achieved the #1 ranking for the first time. I thought I was on top of the world. And I was—until two months later, when you walked on the court in Miami in your red sleeveless shirt, showing off those biceps, and you beat me convincingly. All that buzz I’d been hearing about you—about this amazing young player from Mallorca, a generational talent, probably going to win a major someday—it wasn’t just hype.   We were both at the start of our journey and it’s one we ended up taking together. Twenty years later, Rafa, I have to say: What an incredible run you’ve had. Including 14 French Opens—historic! You made Spain proud... you made the whole tennis world proud.   I keep thinking about the memories we’ve shared. Promoting the sport together. Playing that match on half-grass, half-clay. Breaking the all-time attendance record by playing in front of more than 50,000 fans in Cape Town, South Africa. Always cracking each other up. Wearing each other out on the court and then, sometimes, almost literally having to hold each other up during trophy ceremonies.   I’m still grateful you invited me to Mallorca to help launch the Rafa Nadal Academy in 2016. Actually, I kind of invited myself. I knew you were too polite to insist on me being there, but I didn’t want to miss it. You have always been a role model for kids around the world, and Mirka and I are so glad that our children have all trained at your academies. They had a blast and learned so much—like thousands of other young players. Although I always worried my kids would come home playing tennis as lefties.   And then there was London—the Laver Cup in 2022. My final match. It meant everything to me that you were there by my side—not as my rival but as my doubles partner. Sharing the court with you that night, and sharing those tears, will forever be one of the most special moments of my career.   Rafa, I know you’re focused on the last stretch of your epic career. We will talk when it’s done. For now, I just want to congratulate your family and team, who all played a massive role in your success. And I want you to know that your old friend is always cheering for you, and will be cheering just as loud for everything you do next.   Rafa that!   Best always, your fan, 
 Roger