Asst. Prof @JohnsHopkins; Broadly interested in neurotechnology, genetically encoded tools, and materials science.
Joined February 2020
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🚨 Today in @Nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n]
nature.com/articles/s41586-0…
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Dingchang Lin retweeted
May 22
Earlier this week I posted an example of a fake western blot provided by ThermoFisher to demonstrate the validity of a p53 antibody. I considered it an amusing curiosity. In fact ThermoFisher has systematically manipulated antibody validation data. Short Thread... 🧵
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May 20
Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell.
In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉
nature.com/articles/s41586-0… led by @Dorie00 & @yingchen733
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Dingchang Lin retweeted
May 20
A growing protein cage has no architect.
Each piece only responds to its local environment.
Yet somehow, thousands of pieces can come together to form a large, precise sphere.
Today in @Nature, two back-to-back papers from our team and @UWproteindesign show how de novo protein design can make this kind of self-assembly programmable.
The trick: we didn't design perfect symmetry.
We designed the rules for breaking it. [1/17]
rdcu.be/fjNgF
nature.com/articles/s41586-0…
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Dingchang Lin retweeted
May 17
Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures", but their own internal data.
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Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)
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Dingchang Lin retweeted
Apr 30
1/ Excited to share our new Review in @Nature:
“The past, present and future of de novo protein design.”
Here, we mainly focused on structure-guided protein design. The field is entering a new phase: now that we can design new proteins, what should we build next?
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Dingchang Lin retweeted
Apr 7
The most beautiful molecular recorder 😍
GEMINI is a self-assembling protein system that records cellular events as physical layers, readable via imaging. Achieves down to 15 min resolution and works nicely in vivo!
From @DingchangLin's lab in @Nature
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Congratulations to the 4 Hopkins Engineers among the 449 scholars newly elected to the American Association for the Advancement of Science (@aaas): Jeff Coller & Michael Miller in @JHUBME, Kalina Hristova in @JHUMaterials, & Rajat Mittal in @jhumeche! engineering.jhu.edu/news/4-h…
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Mar 25
We made this work Open Access! Please check out👉 nature.com/articles/s41586-0…
🚨 Today in @Nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n]
nature.com/articles/s41586-0…
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Dingchang Lin retweeted
Mar 15
Excited to share our new paper on GRAB_PGE2-1.0, the first genetically encoded fluorescent sensor for monitoring spatiotemporal prostaglandin E2 (PGE2) dynamics in vivo! It enables real-time imaging in cultured cells, acute brain slices, and living mice.
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Mar 11
We have developed a new AI-based assay to rapidly identify new molecular targets to inhibit cancer cell migration and metastasis.
See more details here: science.org/doi/10.1126/scia…
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Mar 4
Evo 2, our fully open-source biological foundation model trained on trillions of DNA tokens spanning the entire tree of life, is out in @Nature today
We & the scientific community have done a lot with this @arcinstitute @nvidia model in the last year! 🧵👇
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We are actively recruiting postdocs to push this technology forward! If you are interested please reach out!
🚨 Today in @Nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n]
nature.com/articles/s41586-0…
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🚨 Today in @Nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n]
nature.com/articles/s41586-0…
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Huge shoutout to the Janelia Open Chemistry program for developing and sharing the amazing Janelia Fluor dyes! They are essential for timestamping in GEMINI! [12/n]
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Plasmids for GEMINI are available at @Addgene addgene.org/browse/article/2…
Happy to discuss applications/collaboration! Please reach out! [13/n]
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