We study the interplay between genetics and epigenetics in shaping cell identity, plasticity, and resilience during development and in disease.
Joined May 2021
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16 Photos and videos
Nature research paper: Mitochondria directly interact with the nuclear pore complex
go.nature.com/4v6KCo3
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The Dobreva Lab retweeted
Finally out in @Cellcellpress!
Proteins with long intrinsically disordered regions (IDRs) are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
cell.com/cell/fulltext/S0092…
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The Dobreva Lab retweeted
Jun 8
🚨Excited to share our latest study in Cell Metabolism! By combining spatial metabolomics with multi-omics analyses, we identified the IRG1/itaconate–G6PD axis as a promising therapeutic target in lung cancer 🫁🧬
Great work of @siavash668 👏👏
doi.org/10.1016/j.cmet.2026.…
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The Dobreva Lab retweeted
A generative AI framework unifies human multi-omics to model aging, metabolic health, and intervention response dlvr.it/TSv4rR
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New-found immune cells called ‘ruptoblasts’ explode when triggered, ejecting toxic chemicals capable of delivering death to surrounding cells in just minutes. The cells’ discoverers say that this process, which they call ruptosis, seems to be a new form of cell death.
go.nature.com/4x3SZBT
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Nature research paper: Human haematopoietic stem cells remember inflammatory stress
go.nature.com/4wSMH8h
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The Dobreva Lab retweeted
May 20
Differential assembly of mouse and human tumor microenvironments @NatImmunol @CourauTristan @MaxKrummel @UCSF
nature.com/articles/s41590-0…
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The Dobreva Lab retweeted
May 19
Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7)
cell.com/cell/fulltext/S0092…
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The Dobreva Lab retweeted
Memory-encoded magnetic probiotic microbots soften tumor microenvironments and allow for deeper penetration and boosted tumor treatment. scim.ag/3OYyMfX
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New! Online now: Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling dlvr.it/TSWySZ
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The Dobreva Lab retweeted
Iron-dependent brain reshaping links social isolation to anxiety dlvr.it/TSVz9f
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Exercise as a therapeutic intervention for long-lasting and chronic diseases dlvr.it/TSRmyy
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In a new study, @Anders_S_Hansen Lab have measured chromatin movement at timescales ranging from hundreds of microseconds to hours, allowing them to rigorously quantify those dynamics for the first time. news.mit.edu/2026/how-chroma… @NatureSMB
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The Dobreva Lab retweeted
May 5
Our best shot for preventing many diseases?
Exercise
A @Cell_Metabolism new review
cell.com/cell-metabolism/ful…
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The Dobreva Lab retweeted
⭐️Don't miss this Review published @NatureCancer
as part of our Series on Tumor Heterogeneity and Plasticity
'Heterogeneity and plasticity of cancer-associated fibroblasts'
✒️By Ruth Scherz-Shouval, Mara Sherman and co-authors
🔗nature.com/articles/s43018-0…
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The Dobreva Lab retweeted
Butyrate extends health and lifespan in mice with mitochondrial deficiency
nature.com/articles/s41467-0…
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May 2
Anyone interested in the future of #cancer therapy must read this’
it’s best summary of latest
findings of how brain controls cancer
cell.com/cell/fulltext/S0092…
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May 1
Online Now: When tissue tension creates a mutagenic niche dlvr.it/TSKf3B
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Almost all organs and tissues in the body can develop tumours, but those that affect the heart are seldom observed
go.nature.com/4d7vRcT
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