Sharing my first 1st author paper, now published in Science! For my PhD I engineered CHARM, a compact, enzyme-free epigenetic editor which can be delivered via AAV vector to reach the brain. This work was done in @JswLab with @TessaBertozzi and @ElaineWu0 science.org/doi/10.1126/scie…

But how is anyone supposed to know where to go? These maps are the sum total of what they put out and they’re total garbage How is a regular person supposed to figure this out?

We live in an age of (NIH-funded) biomedical miracles Within your lifetime, prion disease was considered potentially impossible to cure. Now there's a promising path towards one science.org/doi/10.1126/scie…

Sharing my first 1st author paper, now published in Science! For my PhD I engineered CHARM, a compact, enzyme-free epigenetic editor which can be delivered via AAV vector to reach the brain. This work was done in @JswLab with @TessaBertozzi and @ElaineWu0 science.org/doi/10.1126/scie…

.@JswLab and @broadinstitute collaborators have developed a gene-silencing tool that shows promise as a therapy against fatal prion diseases. The tool, called CHARM, paves the way for a new class of genetic approaches to treat certain diseases: wi.mit.edu/news/charmed-coll…

Introducing CHARM: a new epigenome editor to methylate DNA at the promoter of a targeted gene. Our lab's collaboration with @JswLab's @EdwinNNeumann & @TessaBertozzi shows deep silencing of brain PrP Paper: science.org/doi/10.1126/scie… Blog: cureffi.org/2024/06/27/intro…

Excited to share my first paper from grad school out today in @MolecularCell! We systematically define biogenesis pathways for alpha-helical OMM proteins triaged by the NAC and TTC1 chaperone complexes for polytopic and signal-anchored proteins (1/2). cell.com/molecular-cell/full…

On @medrxivpreprint today, we describe the plasma & CSF biomarker changes leading up to symptom onset in 4 cohort study participants who went on to develop active prion disease medrxiv.org/content/10.1101/…

Three of the more costly and frequently used reagents in molecular biology are rolling circle amplification (RCA) mix, chemically competent MachOne (or other E. coli) cells, and Gibson assembly mix. Postdoc Julian Willis—who is starting his own lab in the UK soon—developed homemade recipes for each that reduce costs ~3x (or more at large-scale). Links to each recipe: RCA mix: docs.google.com/spreadsheets… Chemically competent MachOne cells: docs.google.com/spreadsheets… Gibson assembly mix: docs.google.com/spreadsheets…

We are looking for a motivated recent grad (or soon-to-be grad) to join us as a lab technician! A great opportunity to gain research experience for 2-3 years before applying to MD and/or PhD programs. Apply here: shorturl.at/qruFU

Thrilled to share my primary PhD work: a Transcription Factor Atlas for understanding gene regulation and cell engineering @CellCellPress. We created a comprehensive TF ORF library and applied it to profile resulting expression changes. A thread 1/X sciencedirect.com/science/ar…

Exciting work from my undergrad lab. Coral was an amazing mentor!

Our genome-scale Perturb-seq paper is out today in Cell! cell.com/cell/fulltext/S0092… @CellCellPress @JswLab Thanks to all the authors and reviewers for their contributions. See the thread below for key findings.

Excited to share our work using a CRISPR-based lineage tracer to track tumor evolution from a single transformed cell to an aggressive tumor in a genetically engineered KP-Tracer model. It is a great collaboration of the @JswLab, @LabJacks and @YosefLab. cell.com/cell/fulltext/S0092…

We are looking for a motivated recent grad to join us as a lab technician! Perfect opportunity to gain more research experience for 2-3 years before applying to MD and/or PhD programs. Follow the link below to apply: 👉 tinyurl.com/WeissmanLabTech

Excited to share the latest work from my PhD! We performed the first CRISPR activation screen to identify genes that drive solid tumor resistance to T cell-mediated cytotoxicity. A thread 1/X nature.com/articles/s41467-0…

Dual modes of #CRISPR-associated #transposon homing. Now online! bit.ly/3rr1Lqx