Joined December 2018
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5 Oct 2024
First preprint from the lab 🚨
How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process?
biorxiv.org/content/10.1101/…
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Elphege Nora Lab at UCSF retweeted
14 Nov 2024
Target gene responses differ when transcription factor levels are acutely decreased by nuclear export versus degradation
Read this Research Article by James McGehee and Angelike Stathopoulos @Angela_Stathop @stathlab:
journals.biologists.com/dev/…
ALT Figure 1 Dorsal is exported from the nucleus under blue light in dl-LEXY.
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Elphege Nora Lab at UCSF retweeted
15 Nov 2024
Ecstatic to share the first story from my post-doc, co-led with Megan Ostrowski, out now in final form (cell.com/cell/fulltext/S0092…)!
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Elphege Nora Lab at UCSF retweeted
4 Nov 2024
Thrilled to share our new preprint, 'A genome wide code to define cell-type specific CTCF binding and chromatin organization'.
biorxiv.org/content/10.1101/…
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Elphege Nora Lab at UCSF retweeted
31 Oct 2024
‘Human Peoples’ is out @PenguinBooks
A genetic journey through how migrations, admixture (among humans and with Neanderthals and Denisovans), and adaptations to environmental pressures (climate, nutrition, pathogens) shaped our physiology and health today. amazon.co.uk/Human-Peoples-E…
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Elphege Nora Lab at UCSF retweeted
25 Oct 2024
I’m excited to share the first preprint out of the Altemose Lab! This stems from a heroic effort by Dr. Matt Franklin @matt_franklin_ (who's on the job market!), who made surprising discoveries regarding some of the most mysterious regions of the genome. biorxiv.org/content/10.1101/…
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Elphege Nora Lab at UCSF retweeted
24 Oct 2024
In short, we investigated the impact of DNA methylation (5-methyl-CpG) on 1. CTCF promoter-enhancer looping and 2. Polycomb-associated H3K27me3. To our surprise, we found both regulatory mechanisms converge to modulate the expression of Zdbf2, @maxvcg ‘s favourite gene.
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Elphege Nora Lab at UCSF retweeted
23 Oct 2024
🎉Excited to finally share that our new work (previously @biorxivpreprint) is now online at @Nature! A fantastic team effort with amazing collaborators. You can read the paper by using the following link: rdcu.be/dXQs7
A thread 🧵/1
nature.com/articles/s41586-0…
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Elphege Nora Lab at UCSF retweeted
16 Oct 2024
It’s a bit belated, but I am happy to share the latest work from our group, led by a very talented post doc in the lab, Tessa Popay @tessapopay with great support from the 4D Nucleome consortium, Rita Allen, and the Pew Biomedical Scholars.
biorxiv.org/content/10.1101/…
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Elphege Nora Lab at UCSF retweeted
13 Oct 2024
We @YinShenLab are excited to share our work on the functional characterization of enhancers of neuropsychiatric risk genes in human iPSC-induced excitatory neurons using CRISPR tiling deletion screening. biorxiv.org/content/10.1101/… 1/20
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16 Oct 2024
CTCF, just like any transcription factor, binds its target sites on and off.
Turns out considering this dynamic is essential to explain chromosome folding patterns from Hi-C and microscopy, and how they rearrange upon tampering with cohesin.
What an exciting manuscript! 👏
15 Oct 2024
Happy to share work with Hadi, Yao & @Maxime_Tortora characterizing the impact of dynamic CTCF barriers for cohesin loop extrusion
biorxiv.org/content/10.1101/…
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Elphege Nora Lab at UCSF retweeted
11 Oct 2024
📢 New preprint from the lab!
CRISPR-screening wizard 🧙 🧬 @TSchwammle figured out how different signals 🚦 are integrated at the Xist locus.
See his tweetorial below.
biorxiv.org/cgi/content/shor…
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11 Oct 2024
1 week left to apply to the open-rank faculty search for the UCSF dept. of Biochemistry & Biophysics
All area of fundamental biology are welcome
Reach out if you have any questions
21 Aug 2024
Our department of Biochemistry and Biophysics at the University of California San Francisco is recruiting tenure-track faculty
aprecruit.ucsf.edu/JPF05209
We welcome all areas of biology across models - from single molecules to organisms and ecosystems.
Deadline Oct 15 2024
Pls RT
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Elphege Nora Lab at UCSF retweeted
4 Oct 2024
After a massive team effort leaded by the incomparable @NicolaFestuccia I am really happy to share our freshly published @ScienceMagazine ms where we elevate Nr5a2 to the top of gene regulation in the morula.
🔥🔥🔥
Take a look at Nicola's description 👇!
science.org/doi/10.1126/scie…
4 Oct 2024
Our work establishing the orphan nuclear receptor NR5A2 as an essential regulator of early mouse development is finally out! We show that NR5A2 is required for the development of a viable morula.
doi.org/10.1126/science.adg7…
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5 Oct 2024
First preprint from the lab 🚨
How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process?
biorxiv.org/content/10.1101/…
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5 Oct 2024
(20) Additional authors on X: @_RiniShah @Erikacander @LucaBraccioli @bffswithbiology @RobertBlelloch
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6 Oct 2024
(21) Oops, wrong X handle 😅
- meant to tag the one and only Geoff Fudenberg @gfudenberg for key contributions to the transcriptomic analyses and stimulating ideas
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5 Oct 2024
(16) Why? Quite simply, you have now removed the two redundant axes that support long-range enhancer action at Sox2.
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5 Oct 2024
(17) So it’s not that complicated in the end:
If you rely on an enhancer, you will need cohesin extrusion beyond ~18kb.
UNLESS you have a promoter-proximal regulatory element that can synergize with your distal enhancer – which happens independently of cohesin.
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