Shameless promotion of our amazing gene regulation/cancer epigenetics work

Joined October 2017
27 Photos and videos
Jay Gertz retweeted
Glad to share our latest work on The EstroGene2.0 database for endocrine therapy response and resistance in breast cancer models, now published in @Nature_NPJ #npjBCancer, shorturl.at/WPiJK, with the super-multifunctional browser estrogeneii.web.app/

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Jay Gertz retweeted
We thank NCI for supporting our work in 3D cancer genomics! This work was led by our grad student Katie Mortenson, co-supervised by K-T Varley, with close collaborations from Yang Liu, @GertzLab , and @Sven_Bailey.
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This excellent review on estrogen receptor alpha mutations, truncations, heterodimers, and therapies, goes into the history of ERα, current research unlocking unknown aspects of ERα signaling, and future directions of ESR1 investigation @RMJesel @GertzLab pubmed.ncbi.nlm.nih.gov/3864…
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24 Apr 2024
Our work on how enhancers impact estrogen transcription timing and noise is now out in @CellGenomics! Thanks to everyone that helped out on this project! cell.com/cell-genomics/fullt… @tweeterginley @xyzxiaoyang
15 Mar 2023
The latest @GertzLab preprint was just posted. It was a great group effort led by @tweeterginley with help from @xyzxiaoyang lab and John Lis’ lab. In this study, we explored how regulatory elements influence gene expression timing and noise in response to estrogen 1/
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Jay Gertz retweeted
We are recruiting! Time to recirculate this work since there’s still so much to do. If you have expertise in DNA damage repair #DDR and are looking for a postdoctoral position where you can lead clinically-relevant discoveries, please don’t hesitate to reach out. @KUMedCenter
I am proud to share with you our recently published paper showing that obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2 science.org/doi/10.1126/scit…
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Jay Gertz retweeted
This week is National #PostdocAppreciationWeek. Zannel Blanchard, PhD (@xedbee) is a postdoctoral fellow in the Welm lab. She explains the role of a postdoc, what inspired her to become a cancer researcher, and why she loves working here. #HCIproud
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Jay Gertz retweeted
Want to work in the heart of Dublin where cutting-edge research meets a super friendly lab environment? 🍀 Dive into the world of breast cancer brain metastasis with us. Dublin’s warmth and our team’s camaraderie await you! Apply now: euraxess.ec.europa.eu/jobs/1…

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Jay Gertz retweeted
Endometrial cancer is the most common gynecological cancer and high levels of estrogen promote its development. Researchers at HCI, led by @xedbee and @GertzLab, have identified potential new treatment options for people with endometrial cancer. bit.ly/47GqKwn
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Jay Gertz retweeted
My pleasure to have officiated the Gordon Conference Hormone Dependent Cancers 2023 Breast Vs Prostate Football Match. The breast team emerged happy & victorious 4-2 🏆🍾 @MagnaniLab_ICR @oesterreichs @DanielFrigo @damirvareslija @dralexswarbrick @drmcrl @BevanLab @scottdehm
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Jay Gertz retweeted
The second major publication from Zannel's PhD project in the @GertzLab is now published in Molecular Cancer Research. I'm thankful to have had the opportunity to help out on this work that further defines the effects of mutant Estrogen Receptor in #endometrialcancer
.@xedbee et al. show the ER-Y537S mutation mediates unique gene expression changes in #endometrialcancer, and identify CDK9 and NCOA3 as potential therapeutic targets. bit.ly/46MD65G @CraigRushPhD @SpencerArnesen @SigCris @Mattchles @hishammt @GertzLab
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Jay Gertz retweeted
.@xedbee et al. show the ER-Y537S mutation mediates unique gene expression changes in #endometrialcancer, and identify CDK9 and NCOA3 as potential therapeutic targets. bit.ly/46MD65G @CraigRushPhD @SpencerArnesen @SigCris @Mattchles @hishammt @GertzLab
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12 Jun 2023
Congrats to @SpencerArnesen and the rest of the team!! Great to see this fun project out in @NAR_Cancer_EIC!
Excited to share that our recent work regarding the role of microRNAs in ER mutant breast cancer is now out in NAR Cancer! A big thanks to all involved! @GertzLab @xedbee @OConnellLab @AlanaWelm academic.oup.com/narcancer/a…
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Jay Gertz retweeted
It was an honor to be included as one of the @huntsmancancer Breast and Gynecologic Cancer Rising Stars yesterday alongside @KLawsonMichod, Dr. Alessandra Riggio, and Dr. Christopher Weil. It's great to see the impactful work being done on women's cancers.
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Jay Gertz retweeted
22 May 2023
I'm hiring! I have a 2-year funded #endometrial #cancer project for a postdoc with #organoid culture experience. Based in Brisbane with views like this, how can you say no? HMU if you have Qs about the role. Applications close 6th June shorturl.at/abhlz
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Jay Gertz retweeted
Wu et al. show that ESR1 mutations promote FOXA1 localization to retinoid X receptor (RXR) motifs in ER #breastcancer, sensitizing breast cancer cells to RXR antagonists— bit.ly/3ADoN4N @ancasey8 @GertzLab @jennifermxavier @Adrianvlee @oesterreichs
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Jay Gertz retweeted
24 Apr 2023
Complementing the new postdoc position available in our lab imperial.ac.uk/jobs/descript… is an opening for an experienced bioinformatics postdoc. imperial.ac.uk/jobs/descript… DM or contact via the advertisement links.

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