Thiagarajah Lab Twitter @bostonchildrens, @harvardmed ac
Joined February 2021
- Tweets 98
- Following 81
- Followers 127
- Likes 52
6 Photos and videos
18 Dec 2025
🧬 New preprint!
First data from the Gut-AGE study: A comprehensive cellular & spatial atlas of the pediatric duodenum integrating single-cell and spatial profiling with diet, social drivers of health, and environmental exposures.
biorxiv.org/cgi/content/shor…
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10 Dec 2025
Huge thanks to our collaborators and all the lab members who made this work possible! 🙌
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10 Dec 2025
Mechanistically, redox state creates a self-reinforcing circuit linking HIF1α signaling to post-translational regulation of IDH1, a key metabolic enzyme.
This circuit couples local oxygen status to ISC metabolic programming. 🔄🧪
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10 Dec 2025
By tuning cellular redox balance, the niche can shift the balance between asymmetric ISC self-renewal and lineage commitment suggesting that redox is a decision-making signal for stem cells. 🌱⚖️
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10 Dec 2025
We found that hypoxia Wnt signaling collaborate to restrict NOX1—a ROS-generating enzyme—to the crypt base in the distal colon.
This spatial control shapes where stem cells maintain an oxidative state needed for cell-cycle entry. 🔥
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10 Dec 2025
Intestinal stem cells live in niches that vary dramatically along the gut. But how do these microenvironments translate into changes in stem cell behavior?
Our new work shows that cellular redox balance is a key integrator. 🧬⚡
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10 Dec 2025
We look at how intestinal stem cells integrate oxygen levels, Wnt signals, and metabolism for fate decisions in the unique environment of the distal colon
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10 Dec 2025
🚨 New lab paper ! 🚨
“A niche-dependent redox rheostat regulates epithelial stem cell fate.”
An incredible amount of work spearheaded by a very talented scientist - Xi Chen!
nature.com/articles/s41467-0…
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31 May 2025
Also Michael’s paper on an optimized end-to-end system and method for multiplex immunofluorescence imaging - check it out : nature.com/articles/s42003-0…
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31 May 2025
A few lab updates: Our major consortium paper on the genetics of Congenital Diarrheas and Enteropathies came out last month. A major collab between BCH, SickKids (@AleixoMMuise), UCLA (Martin Martin) and Vanderbilt (@GoldenringLab ) pmc.ncbi.nlm.nih.gov/article…
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Thiagarajah Lab retweeted
12 Jun 2024
We are recruiting postdoctoral fellows!
Interested in using quantitative tools to study gene regulation in stem cell-derived developmental models? See below for more info and reach out
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Thiagarajah Lab retweeted
16 May 2024
Super thrilled to share a preprint from the lab biorxiv.org/cgi/content/shor…
We found pH regulates the inflammatory response 🔥in #macrophage by controlling BRD4-dependent transcriptional condensates. In my lab led by @younggouu
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Thiagarajah Lab retweeted
6 May 2024
Modeling the cell biology of monogenetic intestinal epithelial disorders. New Review from Izumi Kaji (@iKajiLab), Jay Thiagarajah (@JRTlab), and James Goldenring (@GoldenringLab) @VUMChealth: hubs.la/Q02vqplj0
#Disease #Physiology #Trafficking
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Thiagarajah Lab retweeted
22 Jan 2024
New postdoc opening in my lab in vascular remodeling studies. We do cool science. Email if interested. @atscommunity @atsearlycareer @endothelialnews @ATS_PC @vascularbiology @jfftweets @UMassVascSurg @PVRI
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Thiagarajah Lab retweeted
Pleasant tidings that our paper's recognized as one of @CellReports Best of 2023.
Special congrats to @pascal_devant, @ElsyNgwa, & @BorsicElvira.
Great collaborators @HaopengXiao & @echouchani.
Super proud together with @JRTlab, @HafnerIva, & @jkagan1.
cell.com/cell-reports/fullte…
19 Dec 2023
The best of Cell Reports 2023 is out. Exciting work on many topics, including a novel posttranslational modification on gasdermin D that promotes pyroptosis.
celrep-bestof2023.elsevierdi…
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16 Oct 2023
Also check out the cover - an amazing EM courtesy of Susan Hagen @BIDMC_Medicine
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16 Oct 2023
Our paper on Microvillus Inclusion Disease and using patient derives enteroids is out! buff.ly/3QiSS2h
A pan lab effort and great collaboration with @iKajiLab and @GoldenringLab. #organoids @harvardmed
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Thiagarajah Lab retweeted
16 Oct 2023
#Cover: Patient-derived enteroids for microvillus inclusion disease: buff.ly/3QiSS2h
The cover image shows a false-color electron micrograph of an enteroid.
@JRTlab @BostonChildrens
#Gastroenterology
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28 Sep 2023
Congratulations to Kate in the lab for receiving the FASEB Early Career Investigator award at the #GESRC. 💪 work!!. @katebugdagwilt
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28 Sep 2023
Great finish to a fun day of meeting, brainstorming and science with the Gut-AGE team! @SyedLabGI_AI @ordovas_phd @DrJSilvester
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