BBSRC Discovery Fellow | #CryoEM 🔬 | Phages - Antimicrobials - Host Takeover | He/Him

Joined August 2009
40 Photos and videos
Pinned Tweet
🎉🎉 🥳 We are very excited to finally share with everyone our latest preprint on a fascinating bacteriophage infecting C. difficile, with 12 structures from a 23 MDa phage! and a few surprises along the way. Let us take you on a tour of phiCD508… A thread 🧵 1/9

ALT A gif of the extended form of phiCD508, rocking back and forth

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🚨 Funded PhD Opportunity - Cryo-EM & Structural Biology (Sheffield, UK) Study toxic bacteriophage proteins targeting drug-resistant Enterococcus. Training in cryo-EM, AlphaFold, protein biochemistry & infection biology. 🔗 Apply by 7 Jan 2026 More info: yorkshirebiosciencedtp.ac.uk

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Contact myself Prof. Per Bullough for more info
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Jason wilson retweeted
27 Nov 2024
We have a fascinating preprint just out, revealing the widespread packaging of bacterial genomic DNA into capsids in the human gut:bit.ly/3B2ajza. Major denizens of the #microbiome implicated with broad potential impact on bacterial evolution and horizontal gene transfer
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Jason wilson retweeted
Check out our new preprint (biorxiv.org/content/10.1101/…) describing widespread bacterial DNA packaging by #bacteriophages and gene transfer agents (GTA) in the human gut #microbiome. Many thanks to @PCMFogg, @JSamWilson, Pavol Bardy, and @colinhillucc for collaborating with us.
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Jason wilson retweeted
🧵one of my favorite tools: Foldseek (1/7) We have traced the evo of species by comparing their proteins. We use models that assign a %similarity between seqs and confidently infer that 2 proteins are homologous if share ≥25% SeqSim. But what happens when it’s less than this?
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Jason wilson retweeted
"Ever wondered how α-latrotoxin, the black widow spider's 🕷️ neurotoxin, turns into a cation-selective channel? Check out our latest manuscript! rdcu.be/dWez3 @NatureComms #Neuroscience #Toxin #cryoEM @Sfb1348 @uni_muenster
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Jason wilson retweeted
🚀Announcing my first (co)first-author manuscript 🚀 "Cell attachment and tail contraction of S. aureus phage phi812" 🔗bit.ly/Phi812 Check out the 🧵 to explore the structural details of phage interaction with Gram bacteria🤯 #PhageTherapy #Research #PhDlife 1/11
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Excited to get started as a BBSRC Discovery Fellow at @ScienceShef in October. I'll be looking to understand how bacteriophages hijack their hosts and how we can exploit that understanding towards new antimicrobials 🔬🦠
Meet the 15 new BBSRC Discovery Fellows who are receiving a collective £6m of investment for early-career independent research. The fellowship scheme, now in its 10th year, supports promising researchers who aspire to secure the future of biosciences. orlo.uk/c0ih2
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A huge thank you also to everyone who supported me during my application 🙏⭐️
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Jason wilson retweeted
Fully funded 4-year PhD position using cutting-edge fluorescence and electron microscopy to study the bacterial cytoskeleton. 🔬🦠🦴 Co-supervised by Martin Goldberg (Durham) and Yulia Yuzenkova (Newcastle). Apply by 22 July! findaphd.com/phds/project/bb…
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Jason wilson retweeted
In the USA in 1943 they produced a film 'Don't be a Sucker' about fascism. It perfectly explains Nigel Farage, Suella Braverman, Tommy Robinson and the entire Right.

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Jason wilson retweeted
16 Jun 2024
We present DRGN-AI for fast, ab initio cryo-EM reconstruction! * learns a neural field from unposed images, * designed for single-shot reconstruction of unfiltered datasets, * finds new states missed by prior approaches! Teamwork led by @ZhongingAlong drgnai.cs.princeton.edu/ 1/
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Jason wilson retweeted
We present a preprint about a “stargate” mechanism of the capsid opening required for genome delivery in members of the Microviridae family. See below for a short manuscript summary (1/9). biorxiv.org/content/10.1101/…
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Jason wilson retweeted
Check out our latest work on #CRISPR-associated #transposons (CAST) published in @MolecularCell! 🤩 authors.elsevier.com/c/1jCED… (1/21)

We want to thank the generous funding from @ERC_Research and @novonordiskfond and that allowed us to complete this work Have a look at the follow-up twetorial by @proteofrankie explaining the findings #crispr #genomeediting #CryoEM #HorizonEU
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Jason wilson retweeted
You can't find a better Postdoc opportunity anywhere else! Fantastic mentor and amazing science!
22 Jan 2024
One week to go until close of applications for a postdoctoral position on phage defence with us here in Durham tinyurl.com/mvwtjvxf
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Jason wilson retweeted
Magnetic Isolation and Concentration (MagIC)-cryo-EM is a new method to enable direct structural analysis of targets captured on nanomagnetic beads, which requires only 0.0005 mg/mL of targets in 100 µL crude solution to make 10 cryo-EM grids. I will explain the magic behind it!
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Jason wilson retweeted
👇🏼My Husband Sam is looking for new positions in the UK👇🏼, he is a brilliant scientist and would thrive in any #industry position that needs a skilled and enthusiastic #chemist! Share & DM with information about jobs⚛️Thanks for your support! #JobHunting linkedin.com/posts/samuel-nu…

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Jason wilson retweeted
Seeking scientist volunteers! Want to practice science communication and help author a ✨comic✨ about your research? I need collaborators for this spring's cohort of SciComm & Comics art students! Please share widely. #STEMeducation #Science #sciart
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