Joined February 2015
- Tweets 392
- Following 415
- Followers 437
- Likes 2,949
12 Photos and videos
Paul Ogongo retweeted
Kenya reaffirms commitment to ending TB, calls for fair vaccine access kbc.co.ke/kenya-reaffirms-co…
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Paul Ogongo retweeted
So we blocked IFNγ in Mtb infected macaques and….the animals were fine. Turns out mice overestimate the importance of IFNγ in TB because IFNγ drives iNOS in mice but not macaques or humans. This means we don’t actually know how T cells suppress Mtb. rdcu.be/ff9GB
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Apr 7
Join us to learn about the science of implementing vaccine clinical trials. Register on the link to be part of the conversation.
Join the WGNV Early Career Researcher Network for an interactive online discussion on the TB vaccine clinical pipeline and career opportunities in clinical research.
📆 7 May 2026
🕧 9:00am EST | 3:00pm CET and SAST | 6:30pm IST
🔗 Learn more and register: tinyurl.com/n2j38px6
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Mar 30
Mar 30
Studying 2 distinct human cohorts with recent exposure to #TB,
doi.org/10.1172/jci.insight.…
Paul Ogongo @JaTcells & team @UCSF find different individual Mycobacterium #tuberculosis antigens induce distinct T cell responses, with important implications for TB #vaccine development.
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Mar 27
It was a fantastic meeting in Cape Town to celebrate progress and navigate through the challenges we face Tuberculosis research.
What a great group! 👏 39 Keystone Symposia & @gatesfoundation scholarship awardees joined us in Cape Town for #KSTB26. With ~1.5M TB deaths annually, this next generation of researchers is driving innovation, collaboration, and progress. #tuberculosis #KeystoneSymposia
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Jan 29
FINALLY OUT: We describe a set of Mtb antigens that preferentially induce Th17 cells against Mtb infection. Th17 cells are associated with contained Mtb infection in humans and animal models of TB, suggesting a protective role.
insight.jci.org/articles/vie…
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Jan 27
IN PRESS: Using Metaclonotypist, we discover dominant immune response to TB driven by a public HLA-associated TCR metaclonotypes. This work opens avenues for biomarker and Mtb antigen discovery for TB vaccine.
nature.com/articles/s41467-0…
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Jan 8
Massive effort from my PhD supervisor, Al Leslie, and team analysing Mtb infected human lung tissue.
In a new study by Mbano, Liu, Leslie @UKZN et al., single-cell & spatial transcriptomics of human #TB lung tissues from individuals in South Africa revealed that MMP1⁺CXCL5⁺ #fibroblasts & SPP1⁺ #macrophages are linked to TB disease & TB lung #granuloma hubs.la/Q03ZLxqt0
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Paul Ogongo retweeted
5 Dec 2025
We still don’t understand how T cells control tuberculosis. Our new paper shows that Mtb-specific T cells in NHP and human lung granulomas make many interesting effector molecules upon TCR stimulation. There’s a whole lot more to T cells in TB than IFNγ!
cell.com/iscience/fulltext/S…
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Paul Ogongo retweeted
24 Nov 2025
Join the #WGNV ECR Network - Virtual Coffee Corner on 4 December 2025 to network, share experiences, and talk about #TBvaccine activities of interest.
📅Date: Thur 4 Dec 2025
🕑Time: 9:00 am EDT / 3:00pm CET | 4:00pm SAST | 7:30 pm IST
🔗tinyurl.com/kj7kuuft
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22 Nov 2025
Fresh out in preprint from @justinelevan and the Feeney lab @UCSF_EXPM
21 Nov 2025
Congenital CMV infection drives oligoclonal expansion of cytotoxic γδ T cells from early fetal progenitors biorxiv.org/content/10.1101/… #biorxiv_immuno
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Paul Ogongo retweeted
10 Nov 2025
In the study, Owen Leddy and colleagues used human phagocytic cells to map TB peptides that activate CD4 T cells, a key immune defense. Guided by this, they designed mRNA immunogens that dramatically improved antigen presentation, offering a promising path toward an effective TB vaccine.
👥 @TheBrysonLab, @JaTcells, @Qingyun_Liu, @HeyuanMNi, et al.
🏛️ @ragoninstitute, @MITdeptofBE, @kochinstitute, @UCSF_EXPM, @UNC_SOM, @AHRI_ETH
💰 @theNCI, @NIAIDNews, @NIH_NIEHS
📘 @ScienceTM: science.org/doi/10.1126/scit…
ALT Screenshot from the linked article in Science Translational Medicine, “Immunopeptidomics can inform the design of mRNA vaccines for the delivery of Mycobacterium tuberculosis MHC class II antigens.”
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Paul Ogongo retweeted
5 Nov 2025
Mycobacterium tuberculosis triggers reduced inflammatory cytokine responses and virulence in mice lacking Tax1bp1
journals.plos.org/plospathog…
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4 Oct 2024
Thanks @TheBrysonLab for the tweetorial as always and the cool science!
3 Oct 2024
Many of the peptides we identified are immunogenic per IEDB. We teamed up with @JaTCells to examine T cell responses to novel epitopes in a small cohort of individuals with prior Mtb exposure and found that some of these novel epitopes identified by MS are also immunogenic.
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25 Oct 2025
Join us at the ECR Coffee Corner at the @newtbvaccines on Nov 6 2025. Looking forward to reconnecting this Early Career Researchers in Tuberculosis.
22 Oct 2025
Join the #WGNV ECR Network - Virtual Coffee Corner on 6 November 2025 to network, share experiences, and talk about #TBvaccine activities of interest.
📅Date: Thur 6 Nov 2025
🕑Time: 9:00 am EDT / 3:00pm CET | 4:00pm SAST | 7:30 pm IST
🔗Register at tinyurl.com/ra6jv6en
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21 Oct 2025
Congratulations to Prof Ndung'u @Thumbi_Ndungu. A role model and an inspiration to many.
20 Oct 2025
Congratulations to #SANTHE Director @Thumbi_Ndungu who was inducted into the US National Academy of Medicine @theNAMedicine this Saturday for his contributions to medical science & global health.
#AfricanLedScience
@SciforAfrica @gatesfoundation @Aidsfonds @ragoninstitute @ucl
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Paul Ogongo retweeted
24 Sep 2025
Human CD4 T cells recognize Mycobacterium #tuberculosis–infected #macrophages amid broader responses, say Volodymyr Stetsenko, Daniel P. Gail, Stephen M. Carpenter et al. @cwrusom hubs.la/Q03KNWrz0
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25 Sep 2025
Interesting observations linking B cells and the Inflammosome axis from @javid_lab and @RBouzeyen Early Antibody-Mediated Immunity to Tuberculosis in Mice Requires NLRP3 biorxiv.org/content/10.1101/…
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16 Sep 2025
NEW Study: Assessing the Impact of SARS-CoV-2 Spike Mutations on Antibody Binding: A Comparative Assessment of the Wuhan and JN.1 Variants’ Full-Length Spikes in a Multiplex Luminex Assay mdpi.com/3501064 #mdpiviruses via @VirusesMDPI
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10 Sep 2025
New Study: We report the dysregulation of CD4 T cell responses by Type 2 Diabetes in people with TB. Increased circulating Th17 cell subsets and altered CD4 maturation and differentiation. Potential explanation for high risk for TB in those with T2D
frontiersin.org/journals/imm…
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